北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial
作者: Hu, Jihong2,3,4; Jiang, Xiongjing2,3,4; Li, Nicole5; Yu, Xuequn6; Perkovic, Vlado5; Chen, Bailing2,3,4; Zhao, Liancheng2,3,4; Neal, Bruce5; Wu, Yangfeng1,2,3,4,6
关键词: central aortic blood pressure ; pulse wave analysis ; randomized trial ; salt substitute ; wave reflection
刊名: HYPERTENSION RESEARCH
发表日期: 2009-04-01
DOI: 10.1038/hr.2009.7
卷: 32, 期:4, 页:282-288
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: BLOOD-PRESSURE ; ARTERIAL STIFFNESS ; ESSENTIAL-HYPERTENSION ; SYSTOLIC HYPERTENSION ; AORTIC PRESSURE ; LOW-SODIUM ; REDUCTION ; DISEASE ; REFLECTIONS ; POTASSIUM
英文摘要:

Reduced-sodium, increased-potassium salt substitutes lower blood pressure but may also have direct effects on vascular structure and arterial function. This study aimed to test the effects of long-term salt substitution on indices of these outcomes. The China Salt Substitute Study was a randomized, controlled trial designed to establish the effects of salt substitute (65% sodium chloride, 25% potassium chloride, 10% magnesium sulfate) compared with regular salt (100% sodium chloride) on blood pressure among 600 high-risk individuals living in six rural areas in northern China over a 12-month intervention period. Data on central aortic blood pressure, aortic pressure augmentation (AUG), augmentation index (AIx), the differences of the peak of first and baseline waves (P(1)-P(0)) and pulse wave reflection time (RT) were collected at randomization and at the completion of follow-up in 187 participants using the Sphygmocor pulse wave analysis system. Mean baseline blood pressure was 150.1/91.4 mm Hg, mean age was 58.4 years, 41% were male and three quarters had a history of vascular disease. After 12 months of intervention, there were significant net reductions in peripheral (7.4 mm Hg, P=0.009) and central (6.9 mm Hg, P=0.011) systolic blood pressure levels and central pulse pressure (4.5 mm Hg, P=0.012) and correspondingly there was a significant net reduction in P(1)-P(0) (3.0 mm Hg, P=0.007), borderline significant net reduction in AUG (1.5 mm Hg, P=0.074) and significant net increase in RT (2.59 ms, P=0.001). There were no detectable reductions in peripheral (2.8 mm Hg, P=0.14) or central (2.4 mm Hg, P=0.13) diastolic blood pressure levels or AIx (0.06%, P=0.96). In conclusion, over the 12-month study period the salt substitute significantly reduced not only peripheral and central systolic blood pressure but also reduced arterial stiffness.

语种: 英语
所属项目编号: 358395
项目资助者: National Heart Foundation of Australia ; Capital Medical Science Development Fund (China) ; George Institute for International Health (Australia) ; Clinical Trials Research Unit (New Zealand) ; National Health and Medical Research Council of Australia
WOS记录号: WOS:000264871400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61800
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.George Inst Int Hlth, Sydney, NSW, Australia
2.George Inst China, Beijing, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
4.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China
5.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
6.Peking Union Med Coll, Beijing 100021, Peoples R China

Recommended Citation:
Hu, Jihong,Jiang, Xiongjing,Li, Nicole,et al. Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial[J]. HYPERTENSION RESEARCH,2009,32(4):282-288.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hu, Jihong]'s Articles
[Jiang, Xiongjing]'s Articles
[Li, Nicole]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hu, Jihong]‘s Articles
[Jiang, Xiongjing]‘s Articles
[Li, Nicole]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace