北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial
作者: Hu, Jihong2,3,4; Jiang, Xiongjing2,3,4; Li, Nicole5; Yu, Xuequn6; Perkovic, Vlado5; Chen, Bailing2,3,4; Zhao, Liancheng2,3,4; Neal, Bruce5; Wu, Yangfeng1,2,3,4,6
关键词: central aortic blood pressure ; pulse wave analysis ; randomized trial ; salt substitute ; wave reflection
刊名: HYPERTENSION RESEARCH
发表日期: 2009-04-01
DOI: 10.1038/hr.2009.7
卷: 32, 期:4, 页:282-288
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: BLOOD-PRESSURE ; ARTERIAL STIFFNESS ; ESSENTIAL-HYPERTENSION ; SYSTOLIC HYPERTENSION ; AORTIC PRESSURE ; LOW-SODIUM ; REDUCTION ; DISEASE ; REFLECTIONS ; POTASSIUM
英文摘要:

Reduced-sodium, increased-potassium salt substitutes lower blood pressure but may also have direct effects on vascular structure and arterial function. This study aimed to test the effects of long-term salt substitution on indices of these outcomes. The China Salt Substitute Study was a randomized, controlled trial designed to establish the effects of salt substitute (65% sodium chloride, 25% potassium chloride, 10% magnesium sulfate) compared with regular salt (100% sodium chloride) on blood pressure among 600 high-risk individuals living in six rural areas in northern China over a 12-month intervention period. Data on central aortic blood pressure, aortic pressure augmentation (AUG), augmentation index (AIx), the differences of the peak of first and baseline waves (P(1)-P(0)) and pulse wave reflection time (RT) were collected at randomization and at the completion of follow-up in 187 participants using the Sphygmocor pulse wave analysis system. Mean baseline blood pressure was 150.1/91.4 mm Hg, mean age was 58.4 years, 41% were male and three quarters had a history of vascular disease. After 12 months of intervention, there were significant net reductions in peripheral (7.4 mm Hg, P=0.009) and central (6.9 mm Hg, P=0.011) systolic blood pressure levels and central pulse pressure (4.5 mm Hg, P=0.012) and correspondingly there was a significant net reduction in P(1)-P(0) (3.0 mm Hg, P=0.007), borderline significant net reduction in AUG (1.5 mm Hg, P=0.074) and significant net increase in RT (2.59 ms, P=0.001). There were no detectable reductions in peripheral (2.8 mm Hg, P=0.14) or central (2.4 mm Hg, P=0.13) diastolic blood pressure levels or AIx (0.06%, P=0.96). In conclusion, over the 12-month study period the salt substitute significantly reduced not only peripheral and central systolic blood pressure but also reduced arterial stiffness.

语种: 英语
所属项目编号: 358395
项目资助者: National Heart Foundation of Australia ; Capital Medical Science Development Fund (China) ; George Institute for International Health (Australia) ; Clinical Trials Research Unit (New Zealand) ; National Health and Medical Research Council of Australia
WOS记录号: WOS:000264871400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61800
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.George Inst Int Hlth, Sydney, NSW, Australia
2.George Inst China, Beijing, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
4.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China
5.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
6.Peking Union Med Coll, Beijing 100021, Peoples R China

Recommended Citation:
Hu, Jihong,Jiang, Xiongjing,Li, Nicole,et al. Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial[J]. HYPERTENSION RESEARCH,2009,32(4):282-288.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hu, Jihong]'s Articles
[Jiang, Xiongjing]'s Articles
[Li, Nicole]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hu, Jihong]‘s Articles
[Jiang, Xiongjing]‘s Articles
[Li, Nicole]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace