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Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial
Hu, Jihong2,3,4; Jiang, Xiongjing2,3,4; Li, Nicole5; Yu, Xuequn6; Perkovic, Vlado5; Chen, Bailing2,3,4; Zhao, Liancheng2,3,4; Neal, Bruce5; Wu, Yangfeng1,2,3,4,6
关键词central aortic blood pressure pulse wave analysis randomized trial salt substitute wave reflection
刊名HYPERTENSION RESEARCH
2009-04-01
DOI10.1038/hr.2009.7
32期:4页:282-288
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
资助者National Heart Foundation of Australia ; Capital Medical Science Development Fund (China) ; George Institute for International Health (Australia) ; Clinical Trials Research Unit (New Zealand) ; National Health and Medical Research Council of Australia ; National Heart Foundation of Australia ; Capital Medical Science Development Fund (China) ; George Institute for International Health (Australia) ; Clinical Trials Research Unit (New Zealand) ; National Health and Medical Research Council of Australia
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]BLOOD-PRESSURE ; ARTERIAL STIFFNESS ; ESSENTIAL-HYPERTENSION ; SYSTOLIC HYPERTENSION ; AORTIC PRESSURE ; LOW-SODIUM ; REDUCTION ; DISEASE ; REFLECTIONS ; POTASSIUM
英文摘要

Reduced-sodium, increased-potassium salt substitutes lower blood pressure but may also have direct effects on vascular structure and arterial function. This study aimed to test the effects of long-term salt substitution on indices of these outcomes. The China Salt Substitute Study was a randomized, controlled trial designed to establish the effects of salt substitute (65% sodium chloride, 25% potassium chloride, 10% magnesium sulfate) compared with regular salt (100% sodium chloride) on blood pressure among 600 high-risk individuals living in six rural areas in northern China over a 12-month intervention period. Data on central aortic blood pressure, aortic pressure augmentation (AUG), augmentation index (AIx), the differences of the peak of first and baseline waves (P(1)-P(0)) and pulse wave reflection time (RT) were collected at randomization and at the completion of follow-up in 187 participants using the Sphygmocor pulse wave analysis system. Mean baseline blood pressure was 150.1/91.4 mm Hg, mean age was 58.4 years, 41% were male and three quarters had a history of vascular disease. After 12 months of intervention, there were significant net reductions in peripheral (7.4 mm Hg, P=0.009) and central (6.9 mm Hg, P=0.011) systolic blood pressure levels and central pulse pressure (4.5 mm Hg, P=0.012) and correspondingly there was a significant net reduction in P(1)-P(0) (3.0 mm Hg, P=0.007), borderline significant net reduction in AUG (1.5 mm Hg, P=0.074) and significant net increase in RT (2.59 ms, P=0.001). There were no detectable reductions in peripheral (2.8 mm Hg, P=0.14) or central (2.4 mm Hg, P=0.13) diastolic blood pressure levels or AIx (0.06%, P=0.96). In conclusion, over the 12-month study period the salt substitute significantly reduced not only peripheral and central systolic blood pressure but also reduced arterial stiffness.

语种英语
所属项目编号358395
资助者National Heart Foundation of Australia ; Capital Medical Science Development Fund (China) ; George Institute for International Health (Australia) ; Clinical Trials Research Unit (New Zealand) ; National Health and Medical Research Council of Australia ; National Heart Foundation of Australia ; Capital Medical Science Development Fund (China) ; George Institute for International Health (Australia) ; Clinical Trials Research Unit (New Zealand) ; National Health and Medical Research Council of Australia
WOS记录号WOS:000264871400010
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61800
专题北京大学公共卫生学院
作者单位1.George Inst Int Hlth, Sydney, NSW, Australia
2.George Inst China, Beijing, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
4.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China
5.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
6.Peking Union Med Coll, Beijing 100021, Peoples R China
推荐引用方式
GB/T 7714
Hu, Jihong,Jiang, Xiongjing,Li, Nicole,et al. Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial[J]. HYPERTENSION RESEARCH,2009,32(4):282-288.
APA Hu, Jihong.,Jiang, Xiongjing.,Li, Nicole.,Yu, Xuequn.,Perkovic, Vlado.,...&Wu, Yangfeng.(2009).Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial.HYPERTENSION RESEARCH,32(4),282-288.
MLA Hu, Jihong,et al."Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial".HYPERTENSION RESEARCH 32.4(2009):282-288.
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