IR@PKUHSC  > 北京大学药学院  > 药物化学系
学科主题药学
Solid-phase synthesis of PNA monomer by Ugi four-component condensation
Wang, WH; Zou, XM; Zhang, X; Fu, YQ; Xu, P
关键词peptide nucleic acids (PNA) Ugi four-component condensation reaction (U-4CR) solid-phase synthesis isocyanide
刊名CHINESE CHEMICAL LETTERS
2005-05-01
16期:5页:585-588
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]PEPTIDE NUCLEIC-ACIDS ; BUILDING-BLOCKS ; DNA ; THYMINE ; RECOGNITION ; POLYAMIDE ; CYTOSINE ; GUANINE ; ADENINE ; STRAND
英文摘要

Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.

语种英语
WOS记录号WOS:000229296800006
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61806
Collection北京大学药学院_药物化学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, WH,Zou, XM,Zhang, X,et al. Solid-phase synthesis of PNA monomer by Ugi four-component condensation[J]. CHINESE CHEMICAL LETTERS,2005,16(5):585-588.
APA Wang, WH,Zou, XM,Zhang, X,Fu, YQ,&Xu, P.(2005).Solid-phase synthesis of PNA monomer by Ugi four-component condensation.CHINESE CHEMICAL LETTERS,16(5),585-588.
MLA Wang, WH,et al."Solid-phase synthesis of PNA monomer by Ugi four-component condensation".CHINESE CHEMICAL LETTERS 16.5(2005):585-588.
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