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学科主题: 药学
题名:
Solid-phase synthesis of PNA monomer by Ugi four-component condensation
作者: Wang, WH; Zou, XM; Zhang, X; Fu, YQ; Xu, P
关键词: peptide nucleic acids (PNA) ; Ugi four-component condensation reaction (U-4CR) ; solid-phase synthesis ; isocyanide
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2005-05-01
卷: 16, 期:5, 页:585-588
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: PEPTIDE NUCLEIC-ACIDS ; BUILDING-BLOCKS ; DNA ; THYMINE ; RECOGNITION ; POLYAMIDE ; CYTOSINE ; GUANINE ; ADENINE ; STRAND
英文摘要:

Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.

语种: 英语
WOS记录号: WOS:000229296800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61806
Appears in Collections:北京大学药学院_药物化学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China

Recommended Citation:
Wang, WH,Zou, XM,Zhang, X,et al. Solid-phase synthesis of PNA monomer by Ugi four-component condensation[J]. CHINESE CHEMICAL LETTERS,2005,16(5):585-588.
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