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A Prospective, Observational Study on the Application of Ultra-Wide-Field Angiography in the Evaluation and Management of Patients with Anterior Uveitis
Chi, Ying; Guo, Chunying; Peng, Yuan; Qiao, Lijun; Yang, Liu1
刊名PLOS ONE
2015-03-27
DOI10.1371/journal.pone.0122749
10期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]RETINAL VEIN OCCLUSION ; FLUORESCEIN ANGIOGRAPHY ; DIABETIC-RETINOPATHY ; POSTERIOR UVEITIS ; NONPERFUSION ; AREAS
英文摘要

Purpose

Evaluation of peripheral retinal vascular changes in anterior uveitis using ultra-wide-field fluorescein angiography.

Design

A prospective, observational study of a case series of patients diagnosed with anterior uveitis.

Methods

Setting: Clinical observation at an academic medical center. Patient or Study Population: A total of 65 eyes of 33 patients corresponded with the research criteria of anterior uveitis in the opinion of specialists of Peking University First Hospital. Observation Procedures: Patients were diagnosed primarily through clinical examinations and conventional fluorescein angiography. Subsequently, ultra-wide-field fluorescein angiograms were obtained for each patient. Main Outcome Measures: The main outcome was the detection of peripheral retinal changes by ultra-wide-field fluorescein angiography, and how these changes influenced the evaluation and management of the disease.

Results

Peripheral vessel leakage was detected in 27 eyes (42%) with anterior uveitis, of which 15 eyes displayed active inflammation and 12 eyes displayed inactive inflammation. Peripheral vessel leakage was found in seven of eight eyes with cystoid macular edema. Cystoid macular edema was detected in 7 of 27 eyes (26%) with peripheral vessel leakage, whereas 1 of 38 eyes (3%) did not display peripheral vessel leakage (p< 0.01). 44.4% of the patients with peripheral vessel leakage had a specific etiology. The relevant treatment strategies were modified based on the results of the ultra-wide-field fluorescein angiography. 12 patients with peripheral vessel leakage and a quiescent anterior segment were added to those receiving topical glucocorticoids, while 3 patients with serious peripheral vessel leakage and an active anterior segment received a sub-Tenon injection of triamcinolone acetonide.

Conclusions

Ultra-wide-field fluorescein angiography was very effective in detecting peripheral retinal vascular pathology in anterior uveitis. The changes found in the periphery were important in the evaluation and management of anterior uveitis.

语种英语
WOS记录号WOS:000352133600194
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61811
专题北京大学第一临床医学院_眼科
作者单位1.Peking Univ, Hosp 1, Dept Ophthalmol, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chi, Ying,Guo, Chunying,Peng, Yuan,et al. A Prospective, Observational Study on the Application of Ultra-Wide-Field Angiography in the Evaluation and Management of Patients with Anterior Uveitis[J]. PLOS ONE,2015,10(3).
APA Chi, Ying,Guo, Chunying,Peng, Yuan,Qiao, Lijun,&Yang, Liu.(2015).A Prospective, Observational Study on the Application of Ultra-Wide-Field Angiography in the Evaluation and Management of Patients with Anterior Uveitis.PLOS ONE,10(3).
MLA Chi, Ying,et al."A Prospective, Observational Study on the Application of Ultra-Wide-Field Angiography in the Evaluation and Management of Patients with Anterior Uveitis".PLOS ONE 10.3(2015).
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