IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia
Yao, GM; Chen, G; Pan, TM
关键词idiopathic oligo- or azoospermia male infertility multiplex PCR Y chromosome microdeletion
刊名JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
2001-11-01
18期:11页:612-616
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]LONG ARM ; SPERMATOGENESIS ; INJECTION ; PCR
英文摘要

Purpose: To determine the relationships between idiopathic oligo- or azoospermia and microdeletions of the Y chromosome.

Methods: Eighteen Y-linked sequence-tagged sites (STSs) in AZF (Azoospermia Factor) region were screened by means of multiplex PCR (Polymerase Chain Reaction) in 50 idiopathic infertile men, including 16 patients with azoospermia. 13 severe oligospermia, and 21 oligospermia.

Results: Microdeletions in the genomic DNA were observed in 8 of 50 cases. 3 with azoospermia, 1 severe oligospermia, and 4 oligospermia. Total deletion rate was 16.0% (8/50). The deletion regions were concentrated on AZFd and AZFc.

Conclusions: Microdeletions of the Y chromosome are an important cause for idiopathic oligo- or azoospermia. Multiplex PCR is a useful technique for detecting the microdeletions. To avoid transmission to their offspring, patients with idiopathic oligo- or azoospermia should be screened for microdeletions of the Y chromosome before ICSI treatment for infertility.

语种英语
WOS记录号WOS:000173254200008
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61820
专题北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yao, GM,Chen, G,Pan, TM. Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2001,18(11):612-616.
APA Yao, GM,Chen, G,&Pan, TM.(2001).Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,18(11),612-616.
MLA Yao, GM,et al."Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 18.11(2001):612-616.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yao, GM]的文章
[Chen, G]的文章
[Pan, TM]的文章
百度学术
百度学术中相似的文章
[Yao, GM]的文章
[Chen, G]的文章
[Pan, TM]的文章
必应学术
必应学术中相似的文章
[Yao, GM]的文章
[Chen, G]的文章
[Pan, TM]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。