| 学科主题 | 临床医学 |
| Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia | |
| Yao, GM; Chen, G; Pan, TM | |
| 关键词 | idiopathic oligo- or azoospermia male infertility multiplex PCR Y chromosome microdeletion |
| 刊名 | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
 |
| 2001-11-01 | |
| 卷 | 18期:11页:612-616 |
| 收录类别 | SCI |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology |
| 研究领域[WOS] | Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology |
| 关键词[WOS] | LONG ARM ; SPERMATOGENESIS ; INJECTION ; PCR |
| 英文摘要 | Purpose: To determine the relationships between idiopathic oligo- or azoospermia and microdeletions of the Y chromosome. Methods: Eighteen Y-linked sequence-tagged sites (STSs) in AZF (Azoospermia Factor) region were screened by means of multiplex PCR (Polymerase Chain Reaction) in 50 idiopathic infertile men, including 16 patients with azoospermia. 13 severe oligospermia, and 21 oligospermia. Results: Microdeletions in the genomic DNA were observed in 8 of 50 cases. 3 with azoospermia, 1 severe oligospermia, and 4 oligospermia. Total deletion rate was 16.0% (8/50). The deletion regions were concentrated on AZFd and AZFc. Conclusions: Microdeletions of the Y chromosome are an important cause for idiopathic oligo- or azoospermia. Multiplex PCR is a useful technique for detecting the microdeletions. To avoid transmission to their offspring, patients with idiopathic oligo- or azoospermia should be screened for microdeletions of the Y chromosome before ICSI treatment for infertility. |
| 语种 | 英语 |
| WOS记录号 | WOS:000173254200008 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/61820 |
| Collection | 北京大学第三临床医学院 |
| 作者单位 | Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100083, Peoples R China |
| Recommended Citation GB/T 7714 | Yao, GM,Chen, G,Pan, TM. Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2001,18(11):612-616. |
| APA | Yao, GM,Chen, G,&Pan, TM.(2001).Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,18(11),612-616. |
| MLA | Yao, GM,et al."Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 18.11(2001):612-616. |
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