IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia
Yao, GM; Chen, G; Pan, TM
关键词idiopathic oligo- or azoospermia male infertility multiplex PCR Y chromosome microdeletion
刊名JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
2001-11-01
18期:11页:612-616
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]LONG ARM ; SPERMATOGENESIS ; INJECTION ; PCR
英文摘要

Purpose: To determine the relationships between idiopathic oligo- or azoospermia and microdeletions of the Y chromosome.

Methods: Eighteen Y-linked sequence-tagged sites (STSs) in AZF (Azoospermia Factor) region were screened by means of multiplex PCR (Polymerase Chain Reaction) in 50 idiopathic infertile men, including 16 patients with azoospermia. 13 severe oligospermia, and 21 oligospermia.

Results: Microdeletions in the genomic DNA were observed in 8 of 50 cases. 3 with azoospermia, 1 severe oligospermia, and 4 oligospermia. Total deletion rate was 16.0% (8/50). The deletion regions were concentrated on AZFd and AZFc.

Conclusions: Microdeletions of the Y chromosome are an important cause for idiopathic oligo- or azoospermia. Multiplex PCR is a useful technique for detecting the microdeletions. To avoid transmission to their offspring, patients with idiopathic oligo- or azoospermia should be screened for microdeletions of the Y chromosome before ICSI treatment for infertility.

语种英语
WOS记录号WOS:000173254200008
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61820
Collection北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Yao, GM,Chen, G,Pan, TM. Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2001,18(11):612-616.
APA Yao, GM,Chen, G,&Pan, TM.(2001).Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,18(11),612-616.
MLA Yao, GM,et al."Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 18.11(2001):612-616.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Yao, GM]'s Articles
[Chen, G]'s Articles
[Pan, TM]'s Articles
百度学术
百度学术Similar articles in
[Yao, GM]'s Articles
[Chen, G]'s Articles
[Pan, TM]'s Articles
必应学术
必应学术Similar articles in
[Yao, GM]'s Articles
[Chen, G]'s Articles
[Pan, TM]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.