Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia

IR@PKUHSC > 北京大学第三临床医学院

学科主题	临床医学
	Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia
	Yao, GM; Chen, G; Pan, TM
关键词	idiopathic oligo- or azoospermia male infertility multiplex PCR Y chromosome microdeletion
刊名	JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
	2001-11-01
卷	18 期:11 页:612-616
收录类别	SCI
文章类型	Article
WOS标题词	Science & Technology
类目[WOS]	Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]	Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]	LONG ARM ; SPERMATOGENESIS ; INJECTION ; PCR
英文摘要	Purpose: To determine the relationships between idiopathic oligo- or azoospermia and microdeletions of the Y chromosome. Methods: Eighteen Y-linked sequence-tagged sites (STSs) in AZF (Azoospermia Factor) region were screened by means of multiplex PCR (Polymerase Chain Reaction) in 50 idiopathic infertile men, including 16 patients with azoospermia. 13 severe oligospermia, and 21 oligospermia. Results: Microdeletions in the genomic DNA were observed in 8 of 50 cases. 3 with azoospermia, 1 severe oligospermia, and 4 oligospermia. Total deletion rate was 16.0% (8/50). The deletion regions were concentrated on AZFd and AZFc. Conclusions: Microdeletions of the Y chromosome are an important cause for idiopathic oligo- or azoospermia. Multiplex PCR is a useful technique for detecting the microdeletions. To avoid transmission to their offspring, patients with idiopathic oligo- or azoospermia should be screened for microdeletions of the Y chromosome before ICSI treatment for infertility.
语种	英语
WOS记录号	WOS:000173254200008
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.bjmu.edu.cn/handle/400002259/61820
专题	北京大学第三临床医学院
作者单位	Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Yao, GM,Chen, G,Pan, TM. Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2001,18(11):612-616.
APA	Yao, GM,Chen, G,&Pan, TM.(2001).Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,18(11),612-616.
MLA	Yao, GM,et al."Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 18.11(2001):612-616.