|Selective Serotonin Reuptake Inhibitors Plus Phosphodiesterase-5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis|
|Bai, Yunjin; Pu, Chunxiao; Han, Ping1; Li, Jinhong; Yuan, Haichao; Tang, Yin; Wang, Xiaoming; Wei, Qiang|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||ERECTILE DYSFUNCTION ; DOUBLE-BLIND ; PHASE-III ; PREVALENCE ; DAPOXETINE ; TRIALS ; MEN ; COMPLAINT ; ATTITUDES ; EFFICACY|
OBJECTIVE To evaluate the efficacy and safety of combination therapy with selective serotonin reuptake inhibitors (SSRIs) and phosphodiesterase-5 (PDE-5) inhibitors for the treatment of premature ejaculation (PE).
METHODS A systematic search of EMBASE, MEDLINE, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews was undertaken to identify articles that referred to the use of a combination of SSRIs and PDE-5 inhibitors for the treatment of PE. A meta-analysis of these clinical studies was performed. The post-treatment intravaginal ejaculatory latency time (IELT) and adverse events (AEs) were used in this meta-analysis.
RESULTS Six publications involving 971 patients were included in the meta-analysis. In the analysis, we found significantly improved IELT in the combination use group compared with the use of SSRIs (mean differences [ MD], 1.01; 95% confidence interval [CI], 0.61-1.41; P<.01) or PDE-5 inhibitors alone (MD, 1.11; 95% CI, 0.79-1.43; P<.01) for PE whether or not these patients suffered from erectile dysfunction. Combined treatment was more efficacious than use of PDE-5 inhibitors alone on sexual satisfaction. Although the occurrence of drug-related AEs in the combination use group was higher than that in the use of SSRIs or PDE-5 inhibitors alone group (37.5% vs 25.63%, P<.01), the most common AEs were mild and tolerable.
CONCLUSION The combined use of SSRIs and PDE-5 inhibitors provided additive favorable effects in men with PE compared with SSRIs or PDE-5 inhibitors monotherapy and was generally well tolerated. (C) 2015 Elsevier Inc.
|作者单位||1.Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China|
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen, Guangdong, Peoples R China
|Bai, Yunjin,Pu, Chunxiao,Han, Ping,et al. Selective Serotonin Reuptake Inhibitors Plus Phosphodiesterase-5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis[J]. UROLOGY,2015,86(4):758-764.|
|APA||Bai, Yunjin.,Pu, Chunxiao.,Han, Ping.,Li, Jinhong.,Yuan, Haichao.,...&Wei, Qiang.(2015).Selective Serotonin Reuptake Inhibitors Plus Phosphodiesterase-5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis.UROLOGY,86(4),758-764.|
|MLA||Bai, Yunjin,et al."Selective Serotonin Reuptake Inhibitors Plus Phosphodiesterase-5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis".UROLOGY 86.4(2015):758-764.|