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学科主题: 临床医学
题名:
Selective Serotonin Reuptake Inhibitors Plus Phosphodiesterase-5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis
作者: Bai, Yunjin; Pu, Chunxiao; Han, Ping1; Li, Jinhong; Yuan, Haichao; Tang, Yin; Wang, Xiaoming; Wei, Qiang
刊名: UROLOGY
发表日期: 2015-10-01
DOI: 10.1016/j.urology.2015.06.045
卷: 86, 期:4, 页:758-764
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ERECTILE DYSFUNCTION ; DOUBLE-BLIND ; PHASE-III ; PREVALENCE ; DAPOXETINE ; TRIALS ; MEN ; COMPLAINT ; ATTITUDES ; EFFICACY
英文摘要:

OBJECTIVE To evaluate the efficacy and safety of combination therapy with selective serotonin reuptake inhibitors (SSRIs) and phosphodiesterase-5 (PDE-5) inhibitors for the treatment of premature ejaculation (PE).

METHODS A systematic search of EMBASE, MEDLINE, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews was undertaken to identify articles that referred to the use of a combination of SSRIs and PDE-5 inhibitors for the treatment of PE. A meta-analysis of these clinical studies was performed. The post-treatment intravaginal ejaculatory latency time (IELT) and adverse events (AEs) were used in this meta-analysis.

RESULTS Six publications involving 971 patients were included in the meta-analysis. In the analysis, we found significantly improved IELT in the combination use group compared with the use of SSRIs (mean differences [ MD], 1.01; 95% confidence interval [CI], 0.61-1.41; P<.01) or PDE-5 inhibitors alone (MD, 1.11; 95% CI, 0.79-1.43; P<.01) for PE whether or not these patients suffered from erectile dysfunction. Combined treatment was more efficacious than use of PDE-5 inhibitors alone on sexual satisfaction. Although the occurrence of drug-related AEs in the combination use group was higher than that in the use of SSRIs or PDE-5 inhibitors alone group (37.5% vs 25.63%, P<.01), the most common AEs were mild and tolerable.

CONCLUSION The combined use of SSRIs and PDE-5 inhibitors provided additive favorable effects in men with PE compared with SSRIs or PDE-5 inhibitors monotherapy and was generally well tolerated. (C) 2015 Elsevier Inc.

语种: 英语
WOS记录号: WOS:000366464300025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61821
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen, Guangdong, Peoples R China

Recommended Citation:
Bai, Yunjin,Pu, Chunxiao,Han, Ping,et al. Selective Serotonin Reuptake Inhibitors Plus Phosphodiesterase-5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis[J]. UROLOGY,2015,86(4):758-764.
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