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Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography
Wang, ZH; Wen, J; Zhang, JZ; Min, Y; Guo, D
关键词Chansu cinobufotalin bufalin cinobufagin resibufogenin lethal poisoning
刊名BIOMEDICAL CHROMATOGRAPHY
2004-06-01
DOI10.1002/bmc.322
18期:5页:318-322
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
英文摘要

A high-performance liquid chromatographic method for the simultaneous quantitation of four bufadienolides-cinobufotalin, bufalin, cinobufagin and resibufogenin-in human liver was investigated. The procedure involved solid phase extraction of human liver with an Oasis(R) HLB cartridge coupled with reversed-phase HPLC and photodiode array detection. Recoveries obtained from spiked liver for the bufadienolides were better than 70%. The linearity was studied up to 1.2 mg/kg and the detection limits of the method were 0.4 ng for cinobufotalin and bufalin and 0.5 ng for cinobufagin and resibufogenin. The developed method was successfully applied to a lethal poisoning case. Copyright (C) 2003 John Wiley Sons, Ltd.

语种英语
WOS记录号WOS:000222879200007
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61827
专题北京大学药学院
作者单位1.Publ Secur Minist, Forens Sci Inst, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Wang, ZH,Wen, J,Zhang, JZ,et al. Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography[J]. BIOMEDICAL CHROMATOGRAPHY,2004,18(5):318-322.
APA Wang, ZH,Wen, J,Zhang, JZ,Min, Y,&Guo, D.(2004).Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography.BIOMEDICAL CHROMATOGRAPHY,18(5),318-322.
MLA Wang, ZH,et al."Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography".BIOMEDICAL CHROMATOGRAPHY 18.5(2004):318-322.
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