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学科主题: 药学
题名:
Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography
作者: Wang, ZH; Wen, J; Zhang, JZ; Min, Y; Guo, D
关键词: Chansu ; cinobufotalin ; bufalin ; cinobufagin ; resibufogenin ; lethal poisoning
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2004-06-01
DOI: 10.1002/bmc.322
卷: 18, 期:5, 页:318-322
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
英文摘要:

A high-performance liquid chromatographic method for the simultaneous quantitation of four bufadienolides-cinobufotalin, bufalin, cinobufagin and resibufogenin-in human liver was investigated. The procedure involved solid phase extraction of human liver with an Oasis(R) HLB cartridge coupled with reversed-phase HPLC and photodiode array detection. Recoveries obtained from spiked liver for the bufadienolides were better than 70%. The linearity was studied up to 1.2 mg/kg and the detection limits of the method were 0.4 ng for cinobufotalin and bufalin and 0.5 ng for cinobufagin and resibufogenin. The developed method was successfully applied to a lethal poisoning case. Copyright (C) 2003 John Wiley Sons, Ltd.

语种: 英语
WOS记录号: WOS:000222879200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61827
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Publ Secur Minist, Forens Sci Inst, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, ZH,Wen, J,Zhang, JZ,et al. Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography[J]. BIOMEDICAL CHROMATOGRAPHY,2004,18(5):318-322.
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