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学科主题: 公共卫生
题名:
Anal Human Papillomavirus Genotyping among HIV-Positive Men Who Have Sex with Men in Xi′an, China
作者: Li, Zhen1,2; Zhang, Haoran1,2; Li, Xiangwei1,2; Yang, Yu3; Xin, Henan1,2; Li, Mufei1,2; Feng, Boxuan1,2; Gao, Lei1,2
刊名: PLOS ONE
发表日期: 2015-04-29
DOI: 10.1371/journal.pone.0125120
卷: 10, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RISK-FACTORS ; INTRAEPITHELIAL NEOPLASIA ; QUADRIVALENT VACCINE ; HPV INFECTION ; PREVALENCE ; COHORT ; METAANALYSIS ; LESIONS ; CANCER ; CELLS
英文摘要:

Background

Anal human papillomavirus (HPV) infection and its related diseases are relatively common in men who have sex with men (MSM), especially in those HIV positive. In China, molecular epidemiology of anal HPV infection among HIV-positive MSM has been sparsely studied.

Methods

A cross-sectional study was conducted among HIV-positive MSM in Xi′an, China between April and July 2014. Anal swabs were collected for HPV genotyping.

Results

A total of 195 HIV-positive MSM were included in this study. HPV genotyping showed that 99.0% (191/193) of participants were positive for at least one of the targeted 37 HPV genotypes. 183 (94.8%) of them were infected with multiple high-risk types and 154 (79.8%) of them with low-risk HPV types. HPV 18 was the most frequently identified high-risk type, followed by HPV 16 and HPV 51. As for low-risk types, HPV11, HPV 6 and HPV 81 were most commonly observe. High-risk HPV infection was found to be associated with the status of antiretroviral therapy (ART), the distribution of low-risk types was observed to be varied by CD4(+)T cell level.

Conclusion

Almost all HIV-positive MSM were anal HPV infected in our study. It is highly recommended to consider regular active screening and preventive intervention of HPV infection among this high risk population.

语种: 英语
所属项目编号: Z121107002512073
项目资助者: Beijing Nova program
WOS记录号: WOS:000353711600127
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61829
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Pathogen Biol, Beijing 100730, Peoples R China
2.Peking Union Med Coll, Beijing 100730, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Li, Zhen,Zhang, Haoran,Li, Xiangwei,et al. Anal Human Papillomavirus Genotyping among HIV-Positive Men Who Have Sex with Men in Xi′an, China[J]. PLOS ONE,2015,10(4).
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