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Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study
Lin, Hui-Jia1; Du, Li-Zhong1; Ma, Xiao-Lu1; Shi, Li-Ping1; Pan, Jia-Hua2; Tong, Xiao-Mei3; Li, Qiu-Ping4; Zhou, Jian-Guo5; Yi, Bing6; Liu, Ling7; Chen, Yun-Bing8; Wei, Qiu-Fen9; Wu, Hui-Qing10; Li, Mei11; Liu, Cui-Qing12; Gao, Xi-Rong13; Xia, Shi-Wen14; Li, Wen-Bin15; Yan, Chao-Ying16; He, Ling17; Liang, Kun18; Zhou, Xiao-Yu19; Han, Shu-Ping20; Lyu, Qin21; Qiu, Yin-Ping22; Li, Wen23; Chen, Dong-Mei24; Lu, Hong-Ru25; Liu, Xiao-Hong26; Liu, Hong27; Lin, Zhen-Lang28,29; Liu, Li30; Zhu, Jia-Jun31; Xiong, Hong32; Yue, Shao-Jie33; Zhuang, Si-Qi34
关键词Extremely Low Birth Weight Infant Mortality National Survey
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine

Background: With the progress of perinatal medicine and neonatal technology, more and more extremely low birth weight (ELBW) survived all over the world. This study was designed to investigate the short-term outcomes of ELBW infants during their Neonatal Intensive Care Unit (NICU) stay in the mainland of China. Methods: All infants admitted to 26 NICUs with a birth weight (BW) < l000 g were included between January l, 2011 and December 31, 2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results: A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age (GA) was 28.1 2.2 weeks, and the mean BW was 868 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants (23.3%) died and another 69 infants (26.7%) died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas (53.6% vs. 35.3%, P = 0.019). BW < 750 g and GA < 28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions: Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.

项目编号2012BAI04B04 ; Y200908620
资助机构National Key Technology Research and Development Program ; Zhejiang Province Ministry of Education
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
作者单位1.Zhejiang Univ, Sch Med, Childrens Hosp, Dept Neonatal Intens Care Unit, Hangzhou 310051, Zhejiang, Peoples R China
2.Anhui Prov Hosp, Dept Neonatol, Hefei 230001, Anhui, Peoples R China
3.Peking Univ, Dept Pediat, Hosp 3, Beijing 100191, Peoples R China
4.Beijing Peoples Liberat Army, Gen Mil Hosp, BaYi Childrens Hosp, Dept Neonatol, Beijing 100000, Peoples R China
5.Fudan Univ, Childrens Hosp, Dept Neonatol, Shanghai 200032, Peoples R China
6.Gansu Prov Matern & Children Care Hosp, Dept Neonatol, Lanzhou 730050, Gansu, Peoples R China
7.Guiyang Maternal & Child Hlth Care Hosp, Dept Neonatol, Guiyang 550003, Guizhou, Peoples R China
8.Women & Children Hosp Guangdong Prov, Dept Neonatol, Guangzhou 510010, Guangdong, Peoples R China
9.Guangxi Maternal & Child Hlth Hosp, Dept Neonatol, Nanning 530003, Guangxi, Peoples R China
10.Guangzhou Med Univ, Dept Neonatol, Affiliated Hosp 3, Guangzhou 510150, Guangdong, Peoples R China
11.Harbin Childrens Hosp, Dept Neonatol, Harbin 150010, Heilongjiang, Peoples R China
12.Childrens Hosp Hebei Prov, Dept Neonatol, Shijiazhuang 050031, Hebei, Peoples R China
13.Hunan Childrens Hosp, Dept Neonatol, Changsha 410007, Hunan, Peoples R China
14.Hubei Matern & Child Heath Hosp, Dept Neonatol, Wuhan 430070, Hubei, Peoples R China
15.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pediat, Wuhan 430030, Hubei, Peoples R China
16.Jilin Univ, Hosp 1, Dept Neonatol, Changchun 130021, Jilin, Peoples R China
17.Jiangxi Prov Childrens Hosp, Dept Neonatol, Nanchang 330006, Jiangxi, Peoples R China
18.Kunming Med Univ, Affiliated Hosp 1, Dept Pediat, Kunming 650032, Yunnan, Peoples R China
19.Nanjing Med Univ, Nanjing Childrens Hosp, Dept Neonatol, Nanjing 320100, Jiangsu, Peoples R China
20.Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Dept Neonatol, Nanjing 210004, Jiangsu, Peoples R China
21.Ningbo Women & Childrens Hosp, Dept Neonatal Intens Care Unit, Ningbo 315012, Zhejiang, Peoples R China
22.Ningxia Med Univ, Gen Hosp, Dept Neonatol, Ningxia 750004, Peoples R China
23.Shandong Univ, Qilu Hosp, Dept Neonatol, Jinan 250012, Shandong, Peoples R China
24.Quanzhou Womens & Childrens Hosp, Dept Neonatol, Quanzhou 362000, Fujian, Peoples R China
25.Shanxi Prov Peoples Hosp, Dept Neonatol, Taiyuan 710068, Shanxi, Peoples R China
26.Shenzhen Childrens Hosp, Dept Neonatol, Shenzhen 518026, Guangdong, Peoples R China
27.Capital Med Univ, Dept Neonatol, Beijing Childrens Hosp, Beijing 100045, Peoples R China
28.Wenzhou Med Univ, Dept Neonatol, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China
29.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325000, Zhejiang, Peoples R China
30.Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Neonatol, Xian 710061, Shaanxi, Peoples R China
31.Zhejiang Univ, Sch Med, Womens Hosp, Dept Neonatol, Hangzhou 310006, Zhejiang, Peoples R China
32.Zhengzhou Childrens Hosp, Dept Neonatol, Zhengzhou 450007, Henan, Peoples R China
33.Cent S Univ, Xiangya Hosp, Dept Neonatol, Changsha 410008, Hunan, Peoples R China
34.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neonatol, Guangzhou 510080, Guangdong, Peoples R China
GB/T 7714
Lin, Hui-Jia,Du, Li-Zhong,Ma, Xiao-Lu,et al. Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study[J]. CHINESE MEDICAL JOURNAL,2015,128(20):2743-2750.
APA Lin, Hui-Jia.,Du, Li-Zhong.,Ma, Xiao-Lu.,Shi, Li-Ping.,Pan, Jia-Hua.,...&Zhuang, Si-Qi.(2015).Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study.CHINESE MEDICAL JOURNAL,128(20),2743-2750.
MLA Lin, Hui-Jia,et al."Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study".CHINESE MEDICAL JOURNAL 128.20(2015):2743-2750.
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