IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Adrenomedullin induces heme oxygenase-1 gene expression and cGMP formation in rat vascular smooth muscle cells
Qi, YF; Dong, LW; Pan, CS; Zhang, J; Geng, B; Zhao, J; Tang, CS
关键词adrenomedullin vascular smooth muscle cells nitric oxide carbon monoxide heme oxygenase
刊名PEPTIDES
2005-07-01
DOI10.1016/j.peptides.2005.01.012
26期:7页:1257-1263
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]CARBON-MONOXIDE PRODUCTION ; NITRIC-OXIDE ; VASODILATION ; PROTECTS ; SYSTEM
英文摘要

Adrenomedullin (ADM) is a potent vasodilatory peptide. It regulates blood pressure by increasing cyclic adenosine monophosphate (cAMP) and guanosine-3′,5-monophosphate (cGMP). We sought to investigate the effect of ADM on heme oxygenase-1 (HO-1) gene expression and cGMP formation in cultured rat vascular smooth muscle cells (VSMCs). ADM treatment, 10(-9) and 10(-8) mol/L, increased cGMP production, and it increased the intracellular cGMP content of platelets coincubated with VSMCs. It increased cGMP content by 158.8 % and 273.5 %, respectively; increased HO-1 activity by 49.5 % and 87 %, respectively; augmented HO-1 protein levels by 66 % and 126 %, respectively; upregulated the steady-state level of HO-1 mRNA by 73 % and 159 %, respectively, and increased HO-1 mRNA transcription synthesis by four- and seven-fold, respectively. These results suggest that ADM induces HO-1 gene expression and cGMP formation in rat VSMCs. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000230155600020
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61834
Collection北京大学第一临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 1, Cardiovasc Res Inst, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Qi, YF,Dong, LW,Pan, CS,et al. Adrenomedullin induces heme oxygenase-1 gene expression and cGMP formation in rat vascular smooth muscle cells[J]. PEPTIDES,2005,26(7):1257-1263.
APA Qi, YF.,Dong, LW.,Pan, CS.,Zhang, J.,Geng, B.,...&Tang, CS.(2005).Adrenomedullin induces heme oxygenase-1 gene expression and cGMP formation in rat vascular smooth muscle cells.PEPTIDES,26(7),1257-1263.
MLA Qi, YF,et al."Adrenomedullin induces heme oxygenase-1 gene expression and cGMP formation in rat vascular smooth muscle cells".PEPTIDES 26.7(2005):1257-1263.
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