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学科主题: 口腔医学
题名:
Clinicopathologic study of 24 cases of cherubism
作者: Meng, XM; Yu, SF; Yu, GY
关键词: cherubism ; jaw ; giant cell lesion
刊名: INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
发表日期: 2005-06-01
DOI: 10.1016/j.ijom.2004.09.006
卷: 34, 期:4, 页:350-356
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]: GIANT-CELL GRANULOMAS ; GENE ; JAWS ; MUTATION ; THERAPY ; LESIONS
英文摘要:

The authors reviewed 24 cases of familial or nonfamilial cherubism. The age at onset was between 6 and 10 years. It was characterized by bilateral painless swelling of jaws and eyes-to-heaven appearance was visible when the maxillae were affected as well. Radiographs showed well-defined multilocular radiolucencies and with age, thick sclerotic borders were visible. A malocclusive and abnormal dentition, worse in the mandible can be seen. Histopathologically, numerous randomly distributed multinucleated giant cells and vascular spaces within a fibrous connective tissue stroma with or without eosinophilic collagen perivascular cuffing were apparent. Multinucleated giant cells were positive for osteoclastic specific markers, tartrate-resistant acid phosphatase and human alpha V beta 3 integrin, 23C6. Results after follow-up were available for 14 cases. Of these, no treatment was carried out in five cases, cherubism resolved (three cases) or grew slowly (two cases); curettage or surgical contouring was performed in seven cases, during the rapid growth of the lesions. This not only gave good immediate results, but also arrested active growth of remnant cherubic lesions and even stimulated bone regeneration. Segmental mandibulectomy followed by reconstruction was performed in two cases with extensive lesion and the risk of pathologic fracture of the mandible, and excellent results were obtained.

语种: 英语
WOS记录号: WOS:000229449100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61836
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Meng, XM,Yu, SF,Yu, GY. Clinicopathologic study of 24 cases of cherubism[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2005,34(4):350-356.
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