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学科主题口腔医学
Clinicopathologic study of 24 cases of cherubism
Meng, XM; Yu, SF; Yu, GY
关键词cherubism jaw giant cell lesion
刊名INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
2005-06-01
DOI10.1016/j.ijom.2004.09.006
34期:4页:350-356
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]GIANT-CELL GRANULOMAS ; GENE ; JAWS ; MUTATION ; THERAPY ; LESIONS
英文摘要

The authors reviewed 24 cases of familial or nonfamilial cherubism. The age at onset was between 6 and 10 years. It was characterized by bilateral painless swelling of jaws and eyes-to-heaven appearance was visible when the maxillae were affected as well. Radiographs showed well-defined multilocular radiolucencies and with age, thick sclerotic borders were visible. A malocclusive and abnormal dentition, worse in the mandible can be seen. Histopathologically, numerous randomly distributed multinucleated giant cells and vascular spaces within a fibrous connective tissue stroma with or without eosinophilic collagen perivascular cuffing were apparent. Multinucleated giant cells were positive for osteoclastic specific markers, tartrate-resistant acid phosphatase and human alpha V beta 3 integrin, 23C6. Results after follow-up were available for 14 cases. Of these, no treatment was carried out in five cases, cherubism resolved (three cases) or grew slowly (two cases); curettage or surgical contouring was performed in seven cases, during the rapid growth of the lesions. This not only gave good immediate results, but also arrested active growth of remnant cherubic lesions and even stimulated bone regeneration. Segmental mandibulectomy followed by reconstruction was performed in two cases with extensive lesion and the risk of pathologic fracture of the mandible, and excellent results were obtained.

语种英语
WOS记录号WOS:000229449100003
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61836
专题北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing 100081, Peoples R China
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Meng, XM,Yu, SF,Yu, GY. Clinicopathologic study of 24 cases of cherubism[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2005,34(4):350-356.
APA Meng, XM,Yu, SF,&Yu, GY.(2005).Clinicopathologic study of 24 cases of cherubism.INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,34(4),350-356.
MLA Meng, XM,et al."Clinicopathologic study of 24 cases of cherubism".INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 34.4(2005):350-356.
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