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学科主题: 临床医学
题名:
Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis
作者: Cui, Z; Zhao, MH; Wang, SX; Liu, G; Zou, WZ; Wang, HY
关键词: antiglomerular basement membrane disease ; immune complexes ; prognosis ; pathogenesis
刊名: RENAL FAILURE
发表日期: 2006
DOI: 10.1080/08860220500461195
卷: 28, 期:1, 页:7-14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: IGA NEPHROPATHY ; GOODPASTURES-SYNDROME ; IV COLLAGEN ; HEYMANN NEPHRITIS ; AUTOANTIBODIES ; RAT ; PROLIFERATION ; RECURRENCE ; EXPRESSION ; SUBCLASSES
英文摘要:

Antiglomerular basement membrane (GBM) disease is characteristically described with linear deposition of IgG along GBM. However, the concurrent glomerular immune complex deposition was not rare and might be contributed to the development of anti-GBM disease. In the current series, glomerular immune complexes were identified in 10 of 47 patients who presented with renal-biopsy-proven anti-GBM disease. Six of the 10 patients complicated with a well-documented glomerulonephritis, including two patients with membranous nephropathy, one patient with IgA nephropathy, one patient with membranoproliferative glomerulonephritis, one patient with Schonlein-Henoch nephritis, and one patient with hepatitis B virus associated membranous nephritis. The other four patients had immune complexes with IgG or IgM predominance deposited in glomerular mesangium without a well-documented glomerulonephritis. Clinical and pathological data of patients with immune complex deposition ( n = 10) were compared with those of patients with anti-GBM disease alone ( n = 37). There was no significant difference in age, gender, clinical and pathological manifestations, and renal outcome between the two groups. In general, the association of glomerular immune complexes did not lead to a benign prognosis. Plasma exchange and extensive immunosuppressive therapy should be carried out as soon as possible. The immune complexes deposited in glomeruli might participate in the initiation of anti-GBM disease.

语种: 英语
WOS记录号: WOS:000235211200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61839
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Cui, Z,Zhao, MH,Wang, SX,et al. Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis[J]. RENAL FAILURE,2006,28(1):7-14.
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