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Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis
Cui, Z; Zhao, MH; Wang, SX; Liu, G; Zou, WZ; Wang, HY
关键词antiglomerular basement membrane disease immune complexes prognosis pathogenesis
刊名RENAL FAILURE
2006
DOI10.1080/08860220500461195
28期:1页:7-14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]IGA NEPHROPATHY ; GOODPASTURES-SYNDROME ; IV COLLAGEN ; HEYMANN NEPHRITIS ; AUTOANTIBODIES ; RAT ; PROLIFERATION ; RECURRENCE ; EXPRESSION ; SUBCLASSES
英文摘要

Antiglomerular basement membrane (GBM) disease is characteristically described with linear deposition of IgG along GBM. However, the concurrent glomerular immune complex deposition was not rare and might be contributed to the development of anti-GBM disease. In the current series, glomerular immune complexes were identified in 10 of 47 patients who presented with renal-biopsy-proven anti-GBM disease. Six of the 10 patients complicated with a well-documented glomerulonephritis, including two patients with membranous nephropathy, one patient with IgA nephropathy, one patient with membranoproliferative glomerulonephritis, one patient with Schonlein-Henoch nephritis, and one patient with hepatitis B virus associated membranous nephritis. The other four patients had immune complexes with IgG or IgM predominance deposited in glomerular mesangium without a well-documented glomerulonephritis. Clinical and pathological data of patients with immune complex deposition ( n = 10) were compared with those of patients with anti-GBM disease alone ( n = 37). There was no significant difference in age, gender, clinical and pathological manifestations, and renal outcome between the two groups. In general, the association of glomerular immune complexes did not lead to a benign prognosis. Plasma exchange and extensive immunosuppressive therapy should be carried out as soon as possible. The immune complexes deposited in glomeruli might participate in the initiation of anti-GBM disease.

语种英语
WOS记录号WOS:000235211200002
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61839
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
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GB/T 7714
Cui, Z,Zhao, MH,Wang, SX,et al. Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis[J]. RENAL FAILURE,2006,28(1):7-14.
APA Cui, Z,Zhao, MH,Wang, SX,Liu, G,Zou, WZ,&Wang, HY.(2006).Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis.RENAL FAILURE,28(1),7-14.
MLA Cui, Z,et al."Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis".RENAL FAILURE 28.1(2006):7-14.
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