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学科主题: 口腔医学
题名:
Impact of Actinomyces naeslundii on bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats with periodontitis
作者: Li, Chun Lei1,2; Seneviratne, Chaminda Jayampath3; Huo, Lei1; Lu, Weijia William4; Zheng, Li Wu1
关键词: Bisphosphonates-related osteonecrosis of the jaws ; Actinomyces naeslundii ; periodontal diseases ; ovariectomy ; rat
刊名: JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
发表日期: 2015-10-01
DOI: 10.1016/j.jcms.2015.07.001
卷: 43, 期:8, 页:1662-1669
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]: RISK-FACTORS ; INFECTED OSTEORADIONECROSIS ; MICROBIAL COMMUNITIES ; ORAL BACTERIA ; PAMIDRONATE ; ZOLEDRONATE ; PREVENTION ; BIOFILMS ; NECROSIS
英文摘要:

Bisphosphonates-related osteonecrosis of the jaws (BRONJ) is a severe complication of BPs therapy with unknown pathogenesis. This study aimed to evaluate the impact of Actinomyces naeslundii (A. naeslundii) on the progression of BRONJ in ovariectomized (OVX) rat model with periodontal diseases. Sixty rats were randomly assigned into four groups. All rats underwent bilateral ovariectomy. Six weeks after surgery, animals with periodontitis induced by ligature placement were administrated with normal saline (NS), NS &A. naeslundii inoculation, zolecdronic acid (ZA) and ZA &A. naeslundii inoculation for 12 weeks, respectively. Loads of total bacteria and A. naeslundii in the mouth were assessed by real time PCR. After sacrifice, the mandibles were harvested for micro-computed tomography (micro-CT) and histological examination. Real-time PCR demonstrated that A. naeslundii was not routinely found in the rats and ZA treatment did not promote its accumulation. Micro-CF examination disclosed that ligature placement induced significant alveolar bone loss, which was greatly attenuated by ZA treatment and aggravated by A. naeslundii. Histological assessment demonstrated that ZA treatment increased the risk of developing BRONJ-like disease but this condition was not worsen with the presence of A. naeslundii. Our study suggested that oral A. naeslundii inoculation aggravated periodontal disease but not BRONJ in our animal model. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: HKU785412
项目资助者: General Research Fund, Research Grant Council of Hong Kong
WOS记录号: WOS:000362604000054
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61842
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Univ Hong Kong, Discipline Oral Diag & Polyclin, Fac Dent, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Dept Oral Med, Sch & Hosp Stamotol, Beijing 100871, Peoples R China
3.Natl Univ Singapore, Fac Dent, Discipline Oral Sci, Singapore 117548, Singapore
4.Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Li, Chun Lei,Seneviratne, Chaminda Jayampath,Huo, Lei,et al. Impact of Actinomyces naeslundii on bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats with periodontitis[J]. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,2015,43(8):1662-1669.
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