IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Impact of Actinomyces naeslundii on bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats with periodontitis
Li, Chun Lei1,2; Seneviratne, Chaminda Jayampath3; Huo, Lei1; Lu, Weijia William4; Zheng, Li Wu1
关键词Bisphosphonates-related osteonecrosis of the jaws Actinomyces naeslundii periodontal diseases ovariectomy rat
刊名JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
2015-10-01
DOI10.1016/j.jcms.2015.07.001
43期:8页:1662-1669
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
资助者General Research Fund, Research Grant Council of Hong Kong ; General Research Fund, Research Grant Council of Hong Kong
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]RISK-FACTORS ; INFECTED OSTEORADIONECROSIS ; MICROBIAL COMMUNITIES ; ORAL BACTERIA ; PAMIDRONATE ; ZOLEDRONATE ; PREVENTION ; BIOFILMS ; NECROSIS
英文摘要

Bisphosphonates-related osteonecrosis of the jaws (BRONJ) is a severe complication of BPs therapy with unknown pathogenesis. This study aimed to evaluate the impact of Actinomyces naeslundii (A. naeslundii) on the progression of BRONJ in ovariectomized (OVX) rat model with periodontal diseases. Sixty rats were randomly assigned into four groups. All rats underwent bilateral ovariectomy. Six weeks after surgery, animals with periodontitis induced by ligature placement were administrated with normal saline (NS), NS &A. naeslundii inoculation, zolecdronic acid (ZA) and ZA &A. naeslundii inoculation for 12 weeks, respectively. Loads of total bacteria and A. naeslundii in the mouth were assessed by real time PCR. After sacrifice, the mandibles were harvested for micro-computed tomography (micro-CT) and histological examination. Real-time PCR demonstrated that A. naeslundii was not routinely found in the rats and ZA treatment did not promote its accumulation. Micro-CF examination disclosed that ligature placement induced significant alveolar bone loss, which was greatly attenuated by ZA treatment and aggravated by A. naeslundii. Histological assessment demonstrated that ZA treatment increased the risk of developing BRONJ-like disease but this condition was not worsen with the presence of A. naeslundii. Our study suggested that oral A. naeslundii inoculation aggravated periodontal disease but not BRONJ in our animal model. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

语种英语
所属项目编号HKU785412
资助者General Research Fund, Research Grant Council of Hong Kong ; General Research Fund, Research Grant Council of Hong Kong
WOS记录号WOS:000362604000054
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61842
专题北京大学口腔医学院
作者单位1.Univ Hong Kong, Discipline Oral Diag & Polyclin, Fac Dent, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Dept Oral Med, Sch & Hosp Stamotol, Beijing 100871, Peoples R China
3.Natl Univ Singapore, Fac Dent, Discipline Oral Sci, Singapore 117548, Singapore
4.Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Li, Chun Lei,Seneviratne, Chaminda Jayampath,Huo, Lei,et al. Impact of Actinomyces naeslundii on bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats with periodontitis[J]. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,2015,43(8):1662-1669.
APA Li, Chun Lei,Seneviratne, Chaminda Jayampath,Huo, Lei,Lu, Weijia William,&Zheng, Li Wu.(2015).Impact of Actinomyces naeslundii on bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats with periodontitis.JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,43(8),1662-1669.
MLA Li, Chun Lei,et al."Impact of Actinomyces naeslundii on bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats with periodontitis".JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 43.8(2015):1662-1669.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Chun Lei]的文章
[Seneviratne, Chaminda Jayampath]的文章
[Huo, Lei]的文章
百度学术
百度学术中相似的文章
[Li, Chun Lei]的文章
[Seneviratne, Chaminda Jayampath]的文章
[Huo, Lei]的文章
必应学术
必应学术中相似的文章
[Li, Chun Lei]的文章
[Seneviratne, Chaminda Jayampath]的文章
[Huo, Lei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。