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学科主题: 临床医学
题名:
The risk of carcinogenesis in congenital choledochal cyst patients: an analysis of 214 cases
作者: He, Xiao-dong1,2; Wang, Lei1,2,3; Liu, Wei1,2; Liu, Qi1,2; Qu, Qiang1,2; Li, Bing-lu1,2; Hong, Tao1,2
关键词: Age of onset ; Bile ducts ; Cholangiocarcinoma ; Risk factors ; Surgical procedures
刊名: ANNALS OF HEPATOLOGY
发表日期: 2014-11-01
卷: 13, 期:6, 页:819-826
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INTRAHEPATIC CHOLANGIOCARCINOMA ; PANCREATICOBILIARY MALJUNCTION ; ADULTS ; EXCISION ; CLASSIFICATION ; MALIGNANCY ; MANAGEMENT ; CARCINOMA ; DIAGNOSIS ; RESECTION
英文摘要:

Background. Choledochal cysts are most common in Asian populations. In addition, the incidence of biliary tract malignancies from choledochal cysts is increasing, but the risk of carcinogenesis is still unclear. Material and methods. Clinical data from 214 congenital choledochal cyst cases from 1968 to 2013 were retrospectively analyzed. Results. Todani type I was more common (139, 65.0%) than type IVa (53, 24.8%) or type V (17, 7.9%) in these choledochal cyst patients. Biliary tract malignant tumors occurred in the gallbladder (2, 13.3%), common bile duct (10, 66.7%), and intrahepatic bile duct (3, 20%) in 15 patients (7.0%), including one patient in whom malignant transformation occurred in the intrahepatic bile duct in a type IVa patient 15 years after extrahepatic cyst resection. An age at symptom onset 60 years was a risk factor (p < 0.001), while an initial complete surgery was a protective factor for carcinogenesis (p = 0.001). Conclusions. Choledochal cysts should be removed once diagnosed because of an increased risk of malignant transformation with increasing age. Complete cyst removal is necessary for the first surgical treatment. Additional hepatectomy should be considered for type IVa choledochal cysts because cholangiocarcinoma can arise from the intrahepatic bile duct years after the extrahepatic cyst excision.

语种: 英语
所属项目编号: 81372578
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000347018000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61846
Appears in Collections:北京大学首钢医院_泌尿外科_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gen Surg, Beijing 100730, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Peking Univ, Shougang Hosp, Hlth Sci Ctr, Wu Jieping Urol Ctr, Beijing 100144, Peoples R China

Recommended Citation:
He, Xiao-dong,Wang, Lei,Liu, Wei,et al. The risk of carcinogenesis in congenital choledochal cyst patients: an analysis of 214 cases[J]. ANNALS OF HEPATOLOGY,2014,13(6):819-826.
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