IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats
Chen, GH; Liu, NK; Zhou, AR; Tang, CS; Ma, DL; Tang, J
关键词HRG-1 gene cardiovascular diseases
刊名CHINESE MEDICAL JOURNAL
2001-08-01
114期:8页:833-836
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
英文摘要

Objective To study the role of hypertension-related gene (HRG-1) in cardiovascular disease.

Methods The expression of HRG-1 was analyzed with RT-PCR and Northern blotting. Vascular smooth muscle cell (VSMC) proliferation was measured with H-3-TdR incorporation and was confirmed with histological analysis.

Results Northern blot analysis showed that HRG-1 mRNA was expressed not only in VSMC, but also in various rat tissues (heart, brain, lung, kidney, and liver). In addition, the expression of HRG-1 mRNA in heart, brain, kidney and liver of spontaneously hypertensive rat (SHR) was lower than that in the same tissues of Wistar-Kyotorat (WKY). Semi-quantitative RT-PCR and histological analysis showed that the expression of HRG-1 mRNA in ApoE-knockout mice and in animal models of restenosis was decreased and neointimal formation was observed in both models. ET, All, and IL-1 stimulating VSMC proliferation reduced the expression of HRG-1 mRNA of VSMC. Atrial natriuretic factor (ANF), calcitonin gene-related peptide and adrenomedullin, inhibited VSMC proliferation and elevated the expression of HRG-1 mRNA. These effects could be blocked or attenuated by their corresponding antagonists or antibodies.

Conclusion HRG-1 is a gene related to VSMC proliferation. It may play an important role in several occlusive cardiovascular diseases including atherosclerosis, restenosis and hypertension.

语种英语
WOS记录号WOS:000170838400012
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61847
专题北京大学基础医学院_心血管所
作者单位Beijing Med Univ, Cardiovasc Res Inst, Beijing 100083, Peoples R China
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GB/T 7714
Chen, GH,Liu, NK,Zhou, AR,et al. The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats[J]. CHINESE MEDICAL JOURNAL,2001,114(8):833-836.
APA Chen, GH,Liu, NK,Zhou, AR,Tang, CS,Ma, DL,&Tang, J.(2001).The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats.CHINESE MEDICAL JOURNAL,114(8),833-836.
MLA Chen, GH,et al."The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats".CHINESE MEDICAL JOURNAL 114.8(2001):833-836.
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