| 学科主题 | 基础医学 |
| The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats | |
| Chen, GH; Liu, NK; Zhou, AR; Tang, CS; Ma, DL; Tang, J | |
| 关键词 | HRG-1 gene cardiovascular diseases |
| 刊名 | CHINESE MEDICAL JOURNAL
 |
| 2001-08-01 | |
| 卷 | 114期:8页:833-836 |
| 收录类别 | SCI |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Medicine, General & Internal |
| 研究领域[WOS] | General & Internal Medicine |
| 英文摘要 | Objective To study the role of hypertension-related gene (HRG-1) in cardiovascular disease. Methods The expression of HRG-1 was analyzed with RT-PCR and Northern blotting. Vascular smooth muscle cell (VSMC) proliferation was measured with H-3-TdR incorporation and was confirmed with histological analysis. Results Northern blot analysis showed that HRG-1 mRNA was expressed not only in VSMC, but also in various rat tissues (heart, brain, lung, kidney, and liver). In addition, the expression of HRG-1 mRNA in heart, brain, kidney and liver of spontaneously hypertensive rat (SHR) was lower than that in the same tissues of Wistar-Kyotorat (WKY). Semi-quantitative RT-PCR and histological analysis showed that the expression of HRG-1 mRNA in ApoE-knockout mice and in animal models of restenosis was decreased and neointimal formation was observed in both models. ET, All, and IL-1 stimulating VSMC proliferation reduced the expression of HRG-1 mRNA of VSMC. Atrial natriuretic factor (ANF), calcitonin gene-related peptide and adrenomedullin, inhibited VSMC proliferation and elevated the expression of HRG-1 mRNA. These effects could be blocked or attenuated by their corresponding antagonists or antibodies. Conclusion HRG-1 is a gene related to VSMC proliferation. It may play an important role in several occlusive cardiovascular diseases including atherosclerosis, restenosis and hypertension. |
| 语种 | 英语 |
| WOS记录号 | WOS:000170838400012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/61847 |
| 专题 | 北京大学基础医学院_心血管所 |
| 作者单位 | Beijing Med Univ, Cardiovasc Res Inst, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, GH,Liu, NK,Zhou, AR,et al. The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats[J]. CHINESE MEDICAL JOURNAL,2001,114(8):833-836. |
| APA | Chen, GH,Liu, NK,Zhou, AR,Tang, CS,Ma, DL,&Tang, J.(2001).The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats.CHINESE MEDICAL JOURNAL,114(8),833-836. |
| MLA | Chen, GH,et al."The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats".CHINESE MEDICAL JOURNAL 114.8(2001):833-836. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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