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学科主题: 基础医学
题名:
The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats
作者: Chen, GH; Liu, NK; Zhou, AR; Tang, CS; Ma, DL; Tang, J
关键词: HRG-1 ; gene ; cardiovascular diseases
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-08-01
卷: 114, 期:8, 页:833-836
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
英文摘要:

Objective To study the role of hypertension-related gene (HRG-1) in cardiovascular disease.

Methods The expression of HRG-1 was analyzed with RT-PCR and Northern blotting. Vascular smooth muscle cell (VSMC) proliferation was measured with H-3-TdR incorporation and was confirmed with histological analysis.

Results Northern blot analysis showed that HRG-1 mRNA was expressed not only in VSMC, but also in various rat tissues (heart, brain, lung, kidney, and liver). In addition, the expression of HRG-1 mRNA in heart, brain, kidney and liver of spontaneously hypertensive rat (SHR) was lower than that in the same tissues of Wistar-Kyotorat (WKY). Semi-quantitative RT-PCR and histological analysis showed that the expression of HRG-1 mRNA in ApoE-knockout mice and in animal models of restenosis was decreased and neointimal formation was observed in both models. ET, All, and IL-1 stimulating VSMC proliferation reduced the expression of HRG-1 mRNA of VSMC. Atrial natriuretic factor (ANF), calcitonin gene-related peptide and adrenomedullin, inhibited VSMC proliferation and elevated the expression of HRG-1 mRNA. These effects could be blocked or attenuated by their corresponding antagonists or antibodies.

Conclusion HRG-1 is a gene related to VSMC proliferation. It may play an important role in several occlusive cardiovascular diseases including atherosclerosis, restenosis and hypertension.

语种: 英语
WOS记录号: WOS:000170838400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61847
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: Beijing Med Univ, Cardiovasc Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Chen, GH,Liu, NK,Zhou, AR,et al. The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats[J]. CHINESE MEDICAL JOURNAL,2001,114(8):833-836.
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