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学科主题: 临床医学
题名:
Adenomyoepithelioma of the breast with associated atypical lobular hyperplasia: a previously unrecognized association with management implications
作者: Zhang, Shuang1,2; Huo, Lei1; Arribas, Elsa3; Middleton, Lavinia P.1
关键词: Adenomyoepithelioma ; Atypical lobular hyperplasia ; Myoepithelial ; Pathology
刊名: ANNALS OF DIAGNOSTIC PATHOLOGY
发表日期: 2015-02-01
DOI: 10.1016/j.anndiagpath.2014.11.002
卷: 19, 期:1, 页:20-23
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: MALIGNANT ADENOMYOEPITHELIOMA ; CARCINOMA ; LESIONS
英文摘要:

Adenomyoepitheliomas of breast are rare tumors. We report for the first time a case of an adenomyoepithelioma of the breast with associated lobular neoplasia. A 53-year-old woman had an annual screening mammogram, which identified areas of asymmetry in her left breast at 4-5-o′clock position. Resection of the masses revealed a well-circumscribed, gray-white, firm discrete nodule (0.8 x 0.4 x 0.3 cm). The tumor was composed of both adenomyoepithelial cell hyperplasia and focal atypical lobular hyperplasia. The 2 cell populations had some overlapping histologic features. Immunohistochemical analysis demonstrated a biphasic proliferation with approximately equal parts of luminal epithelial cells with clear and rounded appearance and myoepithelial cells. The myoepithelial component of the proliferation expressed myosin, p63, CK5/6, S-100, and dimly expressed E-cadherin. The epithelial component of the proliferation strongly expressed E-cadherin. In the areas of atypical lobular hyperplasia, there was distinct loss E-cadherin expression. Awareness of this association is highly important to provide these patients adequate follow-up and treatment. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000349506100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61849
Appears in Collections:北京大学第一临床医学院_病理科_期刊论文

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作者单位: 1.Univ Texas MD Anderson Canc Ctr, Dept Pathol & Lab Med, Houston, TX 77030 USA
2.Peking Univ, Hosp 1, Dept Pathol, Beijing 100871, Peoples R China
3.Univ Texas MD Anderson Canc Ctr, Dept Diagnost Radiol, Houston, TX 77030 USA

Recommended Citation:
Zhang, Shuang,Huo, Lei,Arribas, Elsa,et al. Adenomyoepithelioma of the breast with associated atypical lobular hyperplasia: a previously unrecognized association with management implications[J]. ANNALS OF DIAGNOSTIC PATHOLOGY,2015,19(1):20-23.
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