IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
Cell based therapies for ischemic stroke: From basic science to bedside
Liu, Xinfeng1; Ye, Ruidong1; Yan, Tao2,3; Yu, Shan Ping4; Wei, Ling4; Xu, Gelin1; Fan, Xinying1; Jiang, Yongjun1; Stetler, R. Anne5; Liu, George6; Chen, Jieli2
关键词Stem cells Cell-based therapies Ischemic stroke Neurorestoration
刊名PROGRESS IN NEUROBIOLOGY
2014-04-01
DOI10.1016/j.pneurobio.2013.11.007
115期:SI页:92-115
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MESENCHYMAL STEM-CELLS ; MARROW STROMAL CELLS ; UMBILICAL-CORD BLOOD ; FOCAL CEREBRAL-ISCHEMIA ; NEURAL PROGENITOR CELLS ; TISSUE-PLASMINOGEN ACTIVATOR ; PROMOTE FUNCTIONAL RECOVERY ; ARTERY OCCLUSION MODEL ; ACUTE MYOCARDIAL-INFARCTION ; EXOSOME-MEDIATED TRANSFER
英文摘要

Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors from host brain cells, thereby enhancing endogenous brain repair processes. Although stem/progenitor cells have shown a promising role in ischemic stroke in experimental studies as well as initial clinical pilot studies, cellular therapy is still at an early stage in humans. Many critical issues need to be addressed including the therapeutic time window, cell type selection, delivery route, and in vivo monitoring of their migration pattern. This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000334084100006
项目编号31300900 ; 81300993 ; BL2013025 ; AG031811 ; NS057255 ; NS058710 ; R41NS080329
资助机构National Natural Science Foundation of China ; Jiangsu Provincial Special Program of Medical Science ; National Institute on Aging of USA ; National Institute of Health of USA
引用统计
被引频次:78[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61852
专题北京大学基础医学院_心血管所
作者单位1.Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA
2.Emory Univ, Sch Med, Dept Anesthesiol, Atlanta, GA 30322 USA
3.Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China
4.Tianjin Univ, Tianjin Gen Hosp, Sch Med, Dept Neurol, Tianjin 300072, Peoples R China
5.Univ Pittsburgh, Sch Med, Ctr Cerebrovcisc Dis Res, Pittsburgh, PA USA
6.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Xinfeng,Ye, Ruidong,Yan, Tao,et al. Cell based therapies for ischemic stroke: From basic science to bedside[J]. PROGRESS IN NEUROBIOLOGY,2014,115(SI):92-115.
APA Liu, Xinfeng.,Ye, Ruidong.,Yan, Tao.,Yu, Shan Ping.,Wei, Ling.,...&Chen, Jieli.(2014).Cell based therapies for ischemic stroke: From basic science to bedside.PROGRESS IN NEUROBIOLOGY,115(SI),92-115.
MLA Liu, Xinfeng,et al."Cell based therapies for ischemic stroke: From basic science to bedside".PROGRESS IN NEUROBIOLOGY 115.SI(2014):92-115.
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