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学科主题: 基础医学
题名:
Cell based therapies for ischemic stroke: From basic science to bedside
作者: Liu, Xinfeng1; Ye, Ruidong1; Yan, Tao2,3; Yu, Shan Ping4; Wei, Ling4; Xu, Gelin1; Fan, Xinying1; Jiang, Yongjun1; Stetler, R. Anne5; Liu, George6; Chen, Jieli2
关键词: Stem cells ; Cell-based therapies ; Ischemic stroke ; Neurorestoration
刊名: PROGRESS IN NEUROBIOLOGY
发表日期: 2014-04-01
DOI: 10.1016/j.pneurobio.2013.11.007
卷: 115, 期:SI, 页:92-115
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MESENCHYMAL STEM-CELLS ; MARROW STROMAL CELLS ; UMBILICAL-CORD BLOOD ; FOCAL CEREBRAL-ISCHEMIA ; NEURAL PROGENITOR CELLS ; TISSUE-PLASMINOGEN ACTIVATOR ; PROMOTE FUNCTIONAL RECOVERY ; ARTERY OCCLUSION MODEL ; ACUTE MYOCARDIAL-INFARCTION ; EXOSOME-MEDIATED TRANSFER
英文摘要:

Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors from host brain cells, thereby enhancing endogenous brain repair processes. Although stem/progenitor cells have shown a promising role in ischemic stroke in experimental studies as well as initial clinical pilot studies, cellular therapy is still at an early stage in humans. Many critical issues need to be addressed including the therapeutic time window, cell type selection, delivery route, and in vivo monitoring of their migration pattern. This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 31300900 ; 81300993 ; BL2013025 ; AG031811 ; NS057255 ; NS058710 ; R41NS080329
项目资助者: National Natural Science Foundation of China ; Jiangsu Provincial Special Program of Medical Science ; National Institute on Aging of USA ; National Institute of Health of USA
WOS记录号: WOS:000334084100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61852
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA
2.Emory Univ, Sch Med, Dept Anesthesiol, Atlanta, GA 30322 USA
3.Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China
4.Tianjin Univ, Tianjin Gen Hosp, Sch Med, Dept Neurol, Tianjin 300072, Peoples R China
5.Univ Pittsburgh, Sch Med, Ctr Cerebrovcisc Dis Res, Pittsburgh, PA USA
6.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Xinfeng,Ye, Ruidong,Yan, Tao,et al. Cell based therapies for ischemic stroke: From basic science to bedside[J]. PROGRESS IN NEUROBIOLOGY,2014,115(SI):92-115.
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