IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Nasal natural killer/T cell lymphoma with cutaneous involvement: Case report and chinese literature review reported in China mainland
Liu, J; He, ZX; Yong, X; Kai, F; Gao, ZF; Wang, BX
关键词nasal NK/T cell lymphoma pathology immunophenotype
刊名JOURNAL OF DERMATOLOGY
2003-10-01
30期:10页:735-741
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
英文摘要

Nasal natural killer (NK)/T cell lymphoma is an Epstein-Barr virus (EBV) associated lymphoma that arises in the nasal area and aggressively invades surrounding tissues. Our patient was a 48-year-old male who had had nasal obstruction and nasal discharge for 2 years and infiltrating plaques and necrosis on his nasal dorsum for three months. He developed fever and fatigue two weeks before admission. Biopsy from both skin and nasal mucosa revealed atypical medium-sized tumor cells infiltrating into the dermis. Immunohistochemical studies revealed that the tumor cells were UCHL-1, cytoplasmic CD3, CD56, TIA-1, and granzyme B positive, and CD8 and CD20 negative. In situ hybridization for EBN-DNA was positive. Clonal TCRbeta and TCRgamma gene rearrangement were negative. The patient was treated with cyclophosphamide, vincristine, and prednisone (COP) and with local radiotherapy, but lie died 20 days later. We reviewed the cases of nasal NK/T cell lymphoma reported in mainland China in the Chinese literature during the last 5 years.

语种英语
WOS记录号WOS:000186186900008
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61853
Collection北京大学基础医学院_病理学系
作者单位1.Peking Union Med Coll Hosp, Dept Dermatol, Chinese Acad Med Sci, Beijing 100730, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Liu, J,He, ZX,Yong, X,et al. Nasal natural killer/T cell lymphoma with cutaneous involvement: Case report and chinese literature review reported in China mainland[J]. JOURNAL OF DERMATOLOGY,2003,30(10):735-741.
APA Liu, J,He, ZX,Yong, X,Kai, F,Gao, ZF,&Wang, BX.(2003).Nasal natural killer/T cell lymphoma with cutaneous involvement: Case report and chinese literature review reported in China mainland.JOURNAL OF DERMATOLOGY,30(10),735-741.
MLA Liu, J,et al."Nasal natural killer/T cell lymphoma with cutaneous involvement: Case report and chinese literature review reported in China mainland".JOURNAL OF DERMATOLOGY 30.10(2003):735-741.
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