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学科主题基础医学
Amino Acid Polymorphism in the Reverse Transcriptase Region of Hepatitis B Virus and the Relationship With Nucleos(t)ide Analogues Treatment for Preventing Mother-to-Infant Transmission
Chen, Jie1,2; Yan, Ling1,2; Zhu, Feng-Cai3; Liu, Jian-Xun4; Li, Rong-Cheng5; Wang, Fu-Zhen6; Li, Jie1,2; Zhuang, Hui1,2
关键词hepatitis B virus reverse transcriptase nucleos(t)ide analogues perinatal transmission
刊名JOURNAL OF MEDICAL VIROLOGY
2014-08-01
DOI10.1002/jmv.23948
86期:8页:1288-1295
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]ANTIVIRAL RESISTANCE MUTATIONS ; TREATMENT-NAIVE PATIENTS ; SURFACE-ANTIGEN ; PERINATAL TRANSMISSION ; FAMCICLOVIR RESISTANCE ; VERTICAL TRANSMISSION ; POLYMERASE MUTATIONS ; VACCINATION PROGRAM ; LAMIVUDINE THERAPY ; TREATMENT FAILURE
英文摘要

A high maternal serum hepatitis B virus (HBV) DNA level is associated with vaccine failure. The administration of nucleos(t)ide analogues (NAs) in pregnancy for decreasing serum HBV is regarded as an effective and safe method to reduce HBV perinatal transmission. However, the effect of NAs treatment is closely related to amino acid polymorphisms in the HBV reverse transcriptase (RT) region. The full-length RT coding region of 334 HBV isolates from untreated Chinese women of childbearing age with persistent HBV infection were sequenced and amino acid polymorphic analysis was performed to evaluate its impact on NAs treatment for decreasing HBV perinatal transmission. Of the 334 isolates, 36 (10.8%) harbored NAs resistance (NAr) mutations which were mainly putative drug mutations related to lamivudine. The primary drug mutation rtA181T/V was detected in three HBeAg-negative women with an HBV DNA level of <4 log IU/ml. These NAr mutations were rarely detected in women with an HBV DNA level of >= 7 log IU/ml (P = 0.014) or in women younger than 35 years (P = 0.001). The NAr mutation rate among young women (<35 years) who had a high HBV DNA level (>= 7 log IU/ml) was significantly lower than in women who had lower HBV DNA levels (<7 log IU/ml) or who were older (>= 35 years; P = 0.017). These results suggest that younger women with a high HBV DNA level harbor fewer NAr mutations and that this population may respond to NAs treatment for the prevention of mother-to-infant transmission. (C) 2014 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000339486200002
项目编号2008ZX10002-001
资助机构Major Science and Technology Special Project of China Eleventh Five-Year Plan
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61854
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
北京大学第一临床医学院_口腔科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100871, Peoples R China
3.Jiangsu Prov Ctr Dis Control & Prevent, Dept Infect Dis, Nanjing, Jiangsu, Peoples R China
4.Zhengzhou Municipal Ctr Dis Control & Prevent, Dept Major Projects, Zhengzhou, Peoples R China
5.Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Nanning, Peoples R China
6.Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China
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Chen, Jie,Yan, Ling,Zhu, Feng-Cai,et al. Amino Acid Polymorphism in the Reverse Transcriptase Region of Hepatitis B Virus and the Relationship With Nucleos(t)ide Analogues Treatment for Preventing Mother-to-Infant Transmission[J]. JOURNAL OF MEDICAL VIROLOGY,2014,86(8):1288-1295.
APA Chen, Jie.,Yan, Ling.,Zhu, Feng-Cai.,Liu, Jian-Xun.,Li, Rong-Cheng.,...&Zhuang, Hui.(2014).Amino Acid Polymorphism in the Reverse Transcriptase Region of Hepatitis B Virus and the Relationship With Nucleos(t)ide Analogues Treatment for Preventing Mother-to-Infant Transmission.JOURNAL OF MEDICAL VIROLOGY,86(8),1288-1295.
MLA Chen, Jie,et al."Amino Acid Polymorphism in the Reverse Transcriptase Region of Hepatitis B Virus and the Relationship With Nucleos(t)ide Analogues Treatment for Preventing Mother-to-Infant Transmission".JOURNAL OF MEDICAL VIROLOGY 86.8(2014):1288-1295.
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