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学科主题: 基础医学
题名:
Amino Acid Polymorphism in the Reverse Transcriptase Region of Hepatitis B Virus and the Relationship With Nucleos(t)ide Analogues Treatment for Preventing Mother-to-Infant Transmission
作者: Chen, Jie1,2; Yan, Ling1,2; Zhu, Feng-Cai3; Liu, Jian-Xun4; Li, Rong-Cheng5; Wang, Fu-Zhen6; Li, Jie1,2; Zhuang, Hui1,2
关键词: hepatitis B virus ; reverse transcriptase ; nucleos(t)ide analogues ; perinatal transmission
刊名: JOURNAL OF MEDICAL VIROLOGY
发表日期: 2014-08-01
DOI: 10.1002/jmv.23948
卷: 86, 期:8, 页:1288-1295
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: ANTIVIRAL RESISTANCE MUTATIONS ; TREATMENT-NAIVE PATIENTS ; SURFACE-ANTIGEN ; PERINATAL TRANSMISSION ; FAMCICLOVIR RESISTANCE ; VERTICAL TRANSMISSION ; POLYMERASE MUTATIONS ; VACCINATION PROGRAM ; LAMIVUDINE THERAPY ; TREATMENT FAILURE
英文摘要:

A high maternal serum hepatitis B virus (HBV) DNA level is associated with vaccine failure. The administration of nucleos(t)ide analogues (NAs) in pregnancy for decreasing serum HBV is regarded as an effective and safe method to reduce HBV perinatal transmission. However, the effect of NAs treatment is closely related to amino acid polymorphisms in the HBV reverse transcriptase (RT) region. The full-length RT coding region of 334 HBV isolates from untreated Chinese women of childbearing age with persistent HBV infection were sequenced and amino acid polymorphic analysis was performed to evaluate its impact on NAs treatment for decreasing HBV perinatal transmission. Of the 334 isolates, 36 (10.8%) harbored NAs resistance (NAr) mutations which were mainly putative drug mutations related to lamivudine. The primary drug mutation rtA181T/V was detected in three HBeAg-negative women with an HBV DNA level of <4 log IU/ml. These NAr mutations were rarely detected in women with an HBV DNA level of >= 7 log IU/ml (P = 0.014) or in women younger than 35 years (P = 0.001). The NAr mutation rate among young women (<35 years) who had a high HBV DNA level (>= 7 log IU/ml) was significantly lower than in women who had lower HBV DNA levels (<7 log IU/ml) or who were older (>= 35 years; P = 0.017). These results suggest that younger women with a high HBV DNA level harbor fewer NAr mutations and that this population may respond to NAs treatment for the prevention of mother-to-infant transmission. (C) 2014 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 2008ZX10002-001
项目资助者: Major Science and Technology Special Project of China Eleventh Five-Year Plan
WOS记录号: WOS:000339486200002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61854
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100871, Peoples R China
3.Jiangsu Prov Ctr Dis Control & Prevent, Dept Infect Dis, Nanjing, Jiangsu, Peoples R China
4.Zhengzhou Municipal Ctr Dis Control & Prevent, Dept Major Projects, Zhengzhou, Peoples R China
5.Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Nanning, Peoples R China
6.Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

Recommended Citation:
Chen, Jie,Yan, Ling,Zhu, Feng-Cai,et al. Amino Acid Polymorphism in the Reverse Transcriptase Region of Hepatitis B Virus and the Relationship With Nucleos(t)ide Analogues Treatment for Preventing Mother-to-Infant Transmission[J]. JOURNAL OF MEDICAL VIROLOGY,2014,86(8):1288-1295.
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