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学科主题: 临床医学
题名:
Pharmacokinetics of antofloxacin hydrochloride, a new fluoroquinolone antibiotic, after single oral dose administration in Chinese healthy male volunteers
作者: Xiao, Yonghong; Lu, Yuan; Kang, Zisheng; Zhang, Ming; Liu, Yan; Zhang, Man; Li, Tianyun
关键词: antofloxacin hydrochloride ; single dose ; pharmacokinetics ; Chinese healthy male volunteers
刊名: BIOPHARMACEUTICS & DRUG DISPOSITION
发表日期: 2008-04-01
DOI: 10.1002/bdd.600
卷: 29, 期:3, 页:167-172
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要:

Antofloxacin hydrochloride is a newly developed fluoroquinolone antibacterial in China, which has comparable in vitro and animal pharmacological and toxicological properties to levofloxacin and is worthy of further clinical trial. Human tolerance of single escalating doses from 50 to 500mg was shown to be safe. The purpose of the present study was to evaluate the pharmacokinetic characteristics of a single oral dose of antofloxacin hydrochloride in Chinese healthy male volunteers. Twelve subjects were randomized for administration of a single dose of 300, 400 and 500 mg antofloxacin hydrochloride in a 3-way crossover design. High pressure liquid chromatography (HPLC) was used to assay the serum and urine concentrations of antofloxacin in samples collected over a period of 72 h following drug administration. All three dosages were well tolerated. Antofloxacin hydrochloride demonstrated linear pharmacokinetic characteristics with mean pharmacokinetic values varying from 0.09 to 0.101/h/kg for CLIF and from 2.75-3.001/kg for V/F The t(1/2 beta) was around 20 h and the mean fraction of dose excreted in urine varied from 0.40 to 0.46. Based on these data, 300 mg of antofloxacin hydrochloride administered once daily was selected for further investigation in a multiple dose administration study. Copyright (C) 2008 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000256256100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61858
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

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作者单位: Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Xiao, Yonghong,Lu, Yuan,Kang, Zisheng,et al. Pharmacokinetics of antofloxacin hydrochloride, a new fluoroquinolone antibiotic, after single oral dose administration in Chinese healthy male volunteers[J]. BIOPHARMACEUTICS & DRUG DISPOSITION,2008,29(3):167-172.
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