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学科主题临床医学
High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma
Wei, Can1,2,3,4; Wu, Song2,3,4; Li, Xianxin1,2,4; Wang, Yadong2,3,4; Ren, Rui2,3,4; Lai, Yongqing2,3; Ye, Jiongxian1,2
关键词clear cell renal cell carcinoma FER tumorigenesis metastasis prognosis
刊名ONCOLOGY LETTERS
2013-02-01
DOI10.3892/ol.2012.1032
5期:2页:473-478
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PROTEINS ; CYCLE ; CADHERIN ; FPS/FES ; DOMAIN ; GENE
英文摘要

FER tyrosine kinase (FER) has been demonstrated to play a critical role in tumorigenesis and metastasis; however, its potential value as a novel prognostic marker for clear cell renal cell carcinoma (ccRCC) remains unclear. In 48 paired samples of ccRCCs and normal adjacent tissues (ADTs), real-time PCR was used to evaluate the expression of FER mRNA. The expression of FER protein was assessed in 87 ADTs and 206 samples of ccRCC using immunohistochemical methods. Statistical analysis was used to examine the correlations between the expression levels of FER and the clinical characteristics of ccRCC patients. A significant difference was identified between ccRCC tissues and ADTs in the mRNA levels of FER. Immunohistochemistry analyses revealed higher expression of FER protein in 87 ccRCC samples compared to the paired ADTs. In addition, FER protein expression in 206 ccRCC samples was significantly correlated with tumor size, T stage, N classification, metastasis, recurrence and Fuhrman grade, while associations with age and gender were not identifed. The Kaplan-Meier survival analysis showed that patients with high FER levels had a poorer survival outcome compared with those with lower levels. The log-rank test demonstrated that the cumulative survival rates were significantly different between the two groups. The Cox regression analysis indicated that FER expression, N stage and distant metastasis were independent prognostic factors for overall survival of ccRCC patients. Our results indicate that overexpression of FER in tumor tissues predicts a poor prognosis of patients with ccRCC, and FER may serve as a novel prognostic marker for ccRCC.

语种英语
WOS记录号WOS:000313764400012
项目编号81101922 ; CXC201005260001A ; 201003099 ; 2011B061300046
资助机构National Natural Science Foundation of China ; Biobank of Complex Diseases in Shenzhen ; Technology Program of Shenzhen ; Technology Program of Guangdong Province
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61862
专题北京大学深圳医院_泌尿外科
北京大学口腔医学院_第三门诊部
作者单位1.Univ Hong Kong, Dept Med, Shenzhen Hosp, Shenzhen 518053, Peoples R China
2.Peking Univ, Dept Urol, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Peking Univ, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Inst Urol, Shenzhen Hosp,Shenzhen PKU HKUST Med Ctr, Shenzhen 518036, Peoples R China
4.Anhui Med Univ, Clin Coll 1, Dept Med, Hefei, Peoples R China
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GB/T 7714
Wei, Can,Wu, Song,Li, Xianxin,et al. High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma[J]. ONCOLOGY LETTERS,2013,5(2):473-478.
APA Wei, Can.,Wu, Song.,Li, Xianxin.,Wang, Yadong.,Ren, Rui.,...&Ye, Jiongxian.(2013).High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma.ONCOLOGY LETTERS,5(2),473-478.
MLA Wei, Can,et al."High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma".ONCOLOGY LETTERS 5.2(2013):473-478.
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