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学科主题: 临床医学
题名:
High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma
作者: Wei, Can1,2,3,4; Wu, Song2,3,4; Li, Xianxin1,2,4; Wang, Yadong2,3,4; Ren, Rui2,3,4; Lai, Yongqing2,3; Ye, Jiongxian1,2
关键词: clear cell renal cell carcinoma ; FER ; tumorigenesis ; metastasis ; prognosis
刊名: ONCOLOGY LETTERS
发表日期: 2013-02-01
DOI: 10.3892/ol.2012.1032
卷: 5, 期:2, 页:473-478
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PROTEINS ; CYCLE ; CADHERIN ; FPS/FES ; DOMAIN ; GENE
英文摘要:

FER tyrosine kinase (FER) has been demonstrated to play a critical role in tumorigenesis and metastasis; however, its potential value as a novel prognostic marker for clear cell renal cell carcinoma (ccRCC) remains unclear. In 48 paired samples of ccRCCs and normal adjacent tissues (ADTs), real-time PCR was used to evaluate the expression of FER mRNA. The expression of FER protein was assessed in 87 ADTs and 206 samples of ccRCC using immunohistochemical methods. Statistical analysis was used to examine the correlations between the expression levels of FER and the clinical characteristics of ccRCC patients. A significant difference was identified between ccRCC tissues and ADTs in the mRNA levels of FER. Immunohistochemistry analyses revealed higher expression of FER protein in 87 ccRCC samples compared to the paired ADTs. In addition, FER protein expression in 206 ccRCC samples was significantly correlated with tumor size, T stage, N classification, metastasis, recurrence and Fuhrman grade, while associations with age and gender were not identifed. The Kaplan-Meier survival analysis showed that patients with high FER levels had a poorer survival outcome compared with those with lower levels. The log-rank test demonstrated that the cumulative survival rates were significantly different between the two groups. The Cox regression analysis indicated that FER expression, N stage and distant metastasis were independent prognostic factors for overall survival of ccRCC patients. Our results indicate that overexpression of FER in tumor tissues predicts a poor prognosis of patients with ccRCC, and FER may serve as a novel prognostic marker for ccRCC.

语种: 英语
所属项目编号: 81101922 ; CXC201005260001A ; 201003099 ; 2011B061300046
项目资助者: National Natural Science Foundation of China ; Biobank of Complex Diseases in Shenzhen ; Technology Program of Shenzhen ; Technology Program of Guangdong Province
WOS记录号: WOS:000313764400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61862
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Univ Hong Kong, Dept Med, Shenzhen Hosp, Shenzhen 518053, Peoples R China
2.Peking Univ, Dept Urol, Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Peking Univ, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Inst Urol, Shenzhen Hosp,Shenzhen PKU HKUST Med Ctr, Shenzhen 518036, Peoples R China
4.Anhui Med Univ, Clin Coll 1, Dept Med, Hefei, Peoples R China

Recommended Citation:
Wei, Can,Wu, Song,Li, Xianxin,et al. High expression of FER tyrosine kinase predicts poor prognosis in clear cell renal cell carcinoma[J]. ONCOLOGY LETTERS,2013,5(2):473-478.
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