北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Interferon-a Combined with Lamivudine versus Lamivudine Monotherapy for the Emergence of YMDD Mutations in Chronic Hepatitis B Infection: A Meta-Analysis of Randomized Controlled Trials
作者: Zhang, Ya-li; Zhang, Jie; Cui, Li-yan
关键词: Hepatitis B ; Lamivudine ; Interferon ; YMDD mutations ; Meta-analysis
刊名: HEPATO-GASTROENTEROLOGY
发表日期: 2015
DOI: 10.5754/hge14871
卷: 62, 期:137, 页:133-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: E-ANTIGEN SEROCONVERSION ; COMBINATION THERAPY ; LONG-TERM ; ALPHA-INTERFERON ; SEQUENTIAL TREATMENT ; CHINESE PATIENTS ; VIRUS ; SUPPRESSION ; POLYMERASE ; RESISTANCE
英文摘要:

Background/Aims: Tyrosine-methionine-aspartate-aspartate (YMDD) mutations were the main limitation of lamivudine (LAM) for treating chronic hepatitis B (CHB). The aim of this study was to evaluate whether LAM combined with IFN-alpha offer advantage over lamivudine monotherapy for the occurrence of YMDD mutations in CHB using a meta-analysis. Methodology: We searched electronic databases and calculated the odds ratios (OR) with their 95% confidence intervals (CI) and pooled the results. Results: Our meta-analysis indicated that the difference of YMDD mutation rates between the combination therapy of IFN-alpha 2b, IFN-alpha 2a and Peg-IFN-alpha 2a respectively plus LAM and LAM monotherapy (95 % CI, 3.25 - 9.70, 95 % CI, 5.7717.51, 95 % CI, 6.79-26.13, respectively). The rate of YMDD mutations in LAM monotherapy was increased when compared with combination and sequential combination group (95 % CI, 6.79-22.16, and 95 % CI, 2.69-7.75, respectively). The YMDD mutation rate in combination therapy was lower than that of LAM monotherapy in HBeAg positive patients (95 % CI, 4.98-13.23). Conclusions: Our present meta-analysis suggests that different types of IFN-a in combination with LAM can significantly reduce the rate of YMDD mutation compared to LAM monotherapy.

语种: 英语
WOS记录号: WOS:000352115700027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61870
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Ya-li,Zhang, Jie,Cui, Li-yan. Interferon-a Combined with Lamivudine versus Lamivudine Monotherapy for the Emergence of YMDD Mutations in Chronic Hepatitis B Infection: A Meta-Analysis of Randomized Controlled Trials[J]. HEPATO-GASTROENTEROLOGY,2015,62(137):133-139.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Ya-li]'s Articles
[Zhang, Jie]'s Articles
[Cui, Li-yan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Ya-li]‘s Articles
[Zhang, Jie]‘s Articles
[Cui, Li-yan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace