北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Interferon-a Combined with Lamivudine versus Lamivudine Monotherapy for the Emergence of YMDD Mutations in Chronic Hepatitis B Infection: A Meta-Analysis of Randomized Controlled Trials
作者: Zhang, Ya-li; Zhang, Jie; Cui, Li-yan
关键词: Hepatitis B ; Lamivudine ; Interferon ; YMDD mutations ; Meta-analysis
刊名: HEPATO-GASTROENTEROLOGY
发表日期: 2015
DOI: 10.5754/hge14871
卷: 62, 期:137, 页:133-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: E-ANTIGEN SEROCONVERSION ; COMBINATION THERAPY ; LONG-TERM ; ALPHA-INTERFERON ; SEQUENTIAL TREATMENT ; CHINESE PATIENTS ; VIRUS ; SUPPRESSION ; POLYMERASE ; RESISTANCE
英文摘要:

Background/Aims: Tyrosine-methionine-aspartate-aspartate (YMDD) mutations were the main limitation of lamivudine (LAM) for treating chronic hepatitis B (CHB). The aim of this study was to evaluate whether LAM combined with IFN-alpha offer advantage over lamivudine monotherapy for the occurrence of YMDD mutations in CHB using a meta-analysis. Methodology: We searched electronic databases and calculated the odds ratios (OR) with their 95% confidence intervals (CI) and pooled the results. Results: Our meta-analysis indicated that the difference of YMDD mutation rates between the combination therapy of IFN-alpha 2b, IFN-alpha 2a and Peg-IFN-alpha 2a respectively plus LAM and LAM monotherapy (95 % CI, 3.25 - 9.70, 95 % CI, 5.7717.51, 95 % CI, 6.79-26.13, respectively). The rate of YMDD mutations in LAM monotherapy was increased when compared with combination and sequential combination group (95 % CI, 6.79-22.16, and 95 % CI, 2.69-7.75, respectively). The YMDD mutation rate in combination therapy was lower than that of LAM monotherapy in HBeAg positive patients (95 % CI, 4.98-13.23). Conclusions: Our present meta-analysis suggests that different types of IFN-a in combination with LAM can significantly reduce the rate of YMDD mutation compared to LAM monotherapy.

语种: 英语
WOS记录号: WOS:000352115700027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61870
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Dept Lab Med, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Ya-li,Zhang, Jie,Cui, Li-yan. Interferon-a Combined with Lamivudine versus Lamivudine Monotherapy for the Emergence of YMDD Mutations in Chronic Hepatitis B Infection: A Meta-Analysis of Randomized Controlled Trials[J]. HEPATO-GASTROENTEROLOGY,2015,62(137):133-139.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Ya-li]'s Articles
[Zhang, Jie]'s Articles
[Cui, Li-yan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Ya-li]‘s Articles
[Zhang, Jie]‘s Articles
[Cui, Li-yan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace