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Alkaloids from Areca (Betel) Nuts and Their Effects on Human Sperm Motility In Vitro
Yuan, Jingsong1,3; Yang, Dajian2; Liang, Yonghong1; Gao, Wenping3; Ren, Zhipeng3; Zeng, Wei3; Wang, Baorong1; Han, Jian1; Guo, Dean1
关键词arecoline arecaidine areca nut guvacine sperm motility
刊名JOURNAL OF FOOD SCIENCE
2012-04-01
DOI10.1111/j.1750-3841.2012.02653.x
77期:4页:T70-T78
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology
资助者programs of the Shenzhen Science and Technology Project ; Guangdong Traditional Chinese Medicine Administration Bureau for Development of Strong Traditional Chinese Medicine ; programs of the Shenzhen Science and Technology Project ; Guangdong Traditional Chinese Medicine Administration Bureau for Development of Strong Traditional Chinese Medicine
研究领域[WOS]Food Science & Technology
关键词[WOS]LIQUID-CHROMATOGRAPHIC DETERMINATION ; QUADRUPOLE MASS-SPECTROMETRY ; SEMEN ANALYSIS ; BIRTH OUTCOMES ; PAN MASALA ; ARECOLINE ; PREGNANCY ; EXPOSURE ; NICOTINE ; COUPLES
英文摘要

An improved high-performance liquid chromatography (HPLC) method was established to rapidly and simultaneously determine 3 main alkaloids (arecoline, arecaidine, and guvacine) in areca (betel) nuts (AN), and 12 AN samples from the main betel palm growing areas on the Chinese Mainland were collected and determined. Semen samples from acceptable volunteers were treated in vitro with different concentrations of the 3 alkaloids to evaluate the effects on sperm motility (SM). Highly motile spermatozoa were selected from the samples and divided into 5 equal fractions. Various concentrations of each alkaloid were added to 4 of the 5 fractions, and 1 fraction was used as a control. All fractions were incubated for 4 h. A computer-aided sperm analysis system was used to measure 5 SM parameters, motility, average path velocity, straight-line velocity, curvilinear velocity, linearity, and amplitude of lateral head displacement. The results showed that the contents of the amount of alkaloids in AN differed markedly in different places in China and were higher in the kernel than in the husk, and higher in dried AN than in fresh AN. Arecoline had the strongest reduction effect on human SM and the effect was strongly dose dependent. Arecaidine had a much weaker reduction effect than arecoline, and guvacine had the least reduction effect. These findings also demonstrate that betel quid could have adverse effects on the gonadal functions of betel quid consumers.

语种英语
所属项目编号200802022 ; 201002059 ; 2007245
资助者programs of the Shenzhen Science and Technology Project ; Guangdong Traditional Chinese Medicine Administration Bureau for Development of Strong Traditional Chinese Medicine ; programs of the Shenzhen Science and Technology Project ; Guangdong Traditional Chinese Medicine Administration Bureau for Development of Strong Traditional Chinese Medicine
WOS记录号WOS:000302998600055
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61871
专题北京大学药学院
作者单位1.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.State Key Lab Incubat Base Chinese Med & Mol Phar, Shenzhen 518057, Peoples R China
推荐引用方式
GB/T 7714
Yuan, Jingsong,Yang, Dajian,Liang, Yonghong,et al. Alkaloids from Areca (Betel) Nuts and Their Effects on Human Sperm Motility In Vitro[J]. JOURNAL OF FOOD SCIENCE,2012,77(4):T70-T78.
APA Yuan, Jingsong.,Yang, Dajian.,Liang, Yonghong.,Gao, Wenping.,Ren, Zhipeng.,...&Guo, Dean.(2012).Alkaloids from Areca (Betel) Nuts and Their Effects on Human Sperm Motility In Vitro.JOURNAL OF FOOD SCIENCE,77(4),T70-T78.
MLA Yuan, Jingsong,et al."Alkaloids from Areca (Betel) Nuts and Their Effects on Human Sperm Motility In Vitro".JOURNAL OF FOOD SCIENCE 77.4(2012):T70-T78.
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