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学科主题: 药学
题名:
Alkaloids from Areca (Betel) Nuts and Their Effects on Human Sperm Motility In Vitro
作者: Yuan, Jingsong1,3; Yang, Dajian2; Liang, Yonghong1; Gao, Wenping3; Ren, Zhipeng3; Zeng, Wei3; Wang, Baorong1; Han, Jian1; Guo, Dean1
关键词: arecoline ; arecaidine ; areca nut ; guvacine ; sperm motility
刊名: JOURNAL OF FOOD SCIENCE
发表日期: 2012-04-01
DOI: 10.1111/j.1750-3841.2012.02653.x
卷: 77, 期:4, 页:T70-T78
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology
研究领域[WOS]: Food Science & Technology
关键词[WOS]: LIQUID-CHROMATOGRAPHIC DETERMINATION ; QUADRUPOLE MASS-SPECTROMETRY ; SEMEN ANALYSIS ; BIRTH OUTCOMES ; PAN MASALA ; ARECOLINE ; PREGNANCY ; EXPOSURE ; NICOTINE ; COUPLES
英文摘要:

An improved high-performance liquid chromatography (HPLC) method was established to rapidly and simultaneously determine 3 main alkaloids (arecoline, arecaidine, and guvacine) in areca (betel) nuts (AN), and 12 AN samples from the main betel palm growing areas on the Chinese Mainland were collected and determined. Semen samples from acceptable volunteers were treated in vitro with different concentrations of the 3 alkaloids to evaluate the effects on sperm motility (SM). Highly motile spermatozoa were selected from the samples and divided into 5 equal fractions. Various concentrations of each alkaloid were added to 4 of the 5 fractions, and 1 fraction was used as a control. All fractions were incubated for 4 h. A computer-aided sperm analysis system was used to measure 5 SM parameters, motility, average path velocity, straight-line velocity, curvilinear velocity, linearity, and amplitude of lateral head displacement. The results showed that the contents of the amount of alkaloids in AN differed markedly in different places in China and were higher in the kernel than in the husk, and higher in dried AN than in fresh AN. Arecoline had the strongest reduction effect on human SM and the effect was strongly dose dependent. Arecaidine had a much weaker reduction effect than arecoline, and guvacine had the least reduction effect. These findings also demonstrate that betel quid could have adverse effects on the gonadal functions of betel quid consumers.

语种: 英语
所属项目编号: 200802022 ; 201002059 ; 2007245
项目资助者: programs of the Shenzhen Science and Technology Project ; Guangdong Traditional Chinese Medicine Administration Bureau for Development of Strong Traditional Chinese Medicine
WOS记录号: WOS:000302998600055
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61871
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.State Key Lab Incubat Base Chinese Med & Mol Phar, Shenzhen 518057, Peoples R China

Recommended Citation:
Yuan, Jingsong,Yang, Dajian,Liang, Yonghong,et al. Alkaloids from Areca (Betel) Nuts and Their Effects on Human Sperm Motility In Vitro[J]. JOURNAL OF FOOD SCIENCE,2012,77(4):T70-T78.
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