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学科主题: 药学
题名:
Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production
作者: Zhou, Guan-Shen; Ma, Xiao-Li; Zeng, Ke-Wu; Tu, Peng-Fei; Jiang, Yong
关键词: Arenaria serpyllifolia ; Caryophyllaceae ; gamma-pyrone ; nitric oxide production
刊名: PLANTA MEDICA
发表日期: 2013-05-01
DOI: 10.1055/s-0032-1328538
卷: 79, 期:8, 页:687-692
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: CYTOKINES ; LEAVES ; NO
英文摘要:

Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-beta-D-glucopyranoside (1), one new lignan, 3-(beta-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new gamma-pyrones, japonicumone A 4′-O-beta-D-glucopyranoside (3), japonicumone B 3′-O-beta-D-glucopyranoside (4), and japonicumone B 4′- O-beta- D- glucopyranoside (5), together with eight known compounds (6-13) were isolated from the whole plants of Arenaria serpyllifolia. Their structures were elucidated on the basis of extensive spectroscopic analysis (UV, IR, HRESIMS, 1D- and 2D-NMR, and CD) as well as chemical methods. The isolated compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages. Compounds 1-5, sacranoside A (9), and pedunculoside (13) showed potential nitric oxide inhibitory activities with IC50 values ranging from 14.92 mu M to 52.23 mu M.

语种: 英语
所属项目编号: 2012ZX09301002-002-002 ; 2012ZX09304-005 ; 81222051
项目资助者: National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Science Fund for Excellent Young Scholars
WOS记录号: WOS:000319466800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61873
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China

Recommended Citation:
Zhou, Guan-Shen,Ma, Xiao-Li,Zeng, Ke-Wu,et al. Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production[J]. PLANTA MEDICA,2013,79(8):687-692.
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