IR@PKUHSC  > 北京大学药学院
学科主题药学
Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production
Zhou, Guan-Shen; Ma, Xiao-Li; Zeng, Ke-Wu; Tu, Peng-Fei; Jiang, Yong
关键词Arenaria serpyllifolia Caryophyllaceae gamma-pyrone nitric oxide production
刊名PLANTA MEDICA
2013-05-01
DOI10.1055/s-0032-1328538
79期:8页:687-692
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]CYTOKINES ; LEAVES ; NO
英文摘要

Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-beta-D-glucopyranoside (1), one new lignan, 3-(beta-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new gamma-pyrones, japonicumone A 4′-O-beta-D-glucopyranoside (3), japonicumone B 3′-O-beta-D-glucopyranoside (4), and japonicumone B 4′- O-beta- D- glucopyranoside (5), together with eight known compounds (6-13) were isolated from the whole plants of Arenaria serpyllifolia. Their structures were elucidated on the basis of extensive spectroscopic analysis (UV, IR, HRESIMS, 1D- and 2D-NMR, and CD) as well as chemical methods. The isolated compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages. Compounds 1-5, sacranoside A (9), and pedunculoside (13) showed potential nitric oxide inhibitory activities with IC50 values ranging from 14.92 mu M to 52.23 mu M.

语种英语
WOS记录号WOS:000319466800013
项目编号2012ZX09301002-002-002 ; 2012ZX09304-005 ; 81222051
资助机构National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Science Fund for Excellent Young Scholars
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61873
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Guan-Shen,Ma, Xiao-Li,Zeng, Ke-Wu,et al. Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production[J]. PLANTA MEDICA,2013,79(8):687-692.
APA Zhou, Guan-Shen,Ma, Xiao-Li,Zeng, Ke-Wu,Tu, Peng-Fei,&Jiang, Yong.(2013).Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production.PLANTA MEDICA,79(8),687-692.
MLA Zhou, Guan-Shen,et al."Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production".PLANTA MEDICA 79.8(2013):687-692.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhou, Guan-Shen]的文章
[Ma, Xiao-Li]的文章
[Zeng, Ke-Wu]的文章
百度学术
百度学术中相似的文章
[Zhou, Guan-Shen]的文章
[Ma, Xiao-Li]的文章
[Zeng, Ke-Wu]的文章
必应学术
必应学术中相似的文章
[Zhou, Guan-Shen]的文章
[Ma, Xiao-Li]的文章
[Zeng, Ke-Wu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。