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学科主题: 临床医学
题名:
Helicobacter pylori infection in rural China: Exposure to domestic animals during childhood and adulthood
作者: Brown, LM; Thomas, TL; Ma, JL; Chang, YS; You, WC; Liu, WD; Zhang, L; Gail, MH
刊名: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
发表日期: 2001
卷: 33, 期:9, 页:686-691
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: PRECANCEROUS GASTRIC-LESIONS ; HIGH-RISK ; ASYMPTOMATIC POPULATION ; ISOLATE HELICOBACTER ; STOMACH-CANCER ; UNITED-STATES ; CATS ; TRANSMISSION ; PREVALENCE ; DIAGNOSIS
英文摘要:

Little is known about the mode of transmission of Helicobacter pylori, one of the most common human bacterial infections. Some domestic animals, including the cat, have been suggested as a reservoir of H. pylori disease, but the data have been inconsistent. This paper evaluates the role of exposure to pets and other domestic animals in the etiology of H. pylori in a rural area of China with a high prevalence of H. pylori infection. In this double-blind, population-based, cross-sectional investigation, interviews were completed with 3288 (1994 seropositive, 1019 seronegative, 275 indeterminate) H. pylori-infected adults enrolled in a randomized intervention trial in Linqu County, Shandong Province, China. We found no evidence to suggest that exposure to pets or other domestic animals during either childhood or adulthood was related to the prevalence of H. pylori infection. In fact, odds ratios (ORs) were reduced for subjects who had kept a cat (OR = 0.7, 95% CI 0.4-1.0) or any animal (OR = 0.5, 95% CI = 0.3-0.9) in the house as an adult, or a cat as a child (OR = 0.7, 95% CI 0.5-1.0). ORs were also reduced for all 11 types of animal studied that subjects had kept in their courtyard as an adult. These findings suggest that zoonotic transmission, including that from domestic cats, is an unlikely route of H. pylori infection in this rural Chinese population.

语种: 英语
WOS记录号: WOS:000171504800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61875
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Beijing Med Univ, Sch Oncol, Beijing 100083, Peoples R China
2.Linqu Publ Hlth Bur, Linqu, Shandong Prov, Peoples R China
3.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
4.Beijing Med Univ, Beijing Inst Canc Res, Beijing 100083, Peoples R China

Recommended Citation:
Brown, LM,Thomas, TL,Ma, JL,et al. Helicobacter pylori infection in rural China: Exposure to domestic animals during childhood and adulthood[J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES,2001,33(9):686-691.
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