IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
High-normal serum uric acid is associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients
Cai Xiao-ling; Han Xue-yao; Ji Li-nong
关键词serum uric acid estimated glomerular filtration rate albumin-to-creatinine type 2 diabetes
刊名CHINESE MEDICAL JOURNAL
2011-11-20
DOI10.3760/cma.j.issn.0366-6999.2011.22.006
124期:22页:3629-3634
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]BLOOD-PRESSURE ; RENAL-DISEASE ; INDEPENDENT MECHANISM ; HYPERURICEMIA ; MICROALBUMINURIA ; HYPERTENSION ; PROGRESSION ; MELLITUS ; CELLS
英文摘要

Background Recently, some studies had shown that elevated serum uric acid (SUA) itself may increase the risk for development of renal disease in patients with diabetes. This study aimed to explore whether SUA was a predictor of microalbuminuria and impaired renal function in type 2 diabetes in Chinese patients.

Methods This cross-sectional study included 2108 type 2 diabetic patients. Kidney function was estimated using the simplified modification of diet in renal disease (MDRD) equation to obtain estimated glomerular filtration rate. The urine samples were obtained for measuring the albumin-to-creatinine ratio (ACR).

Results According to the ACR level, these patients were divided into two groups, normal ACR (NA) and non-normal ACR (non-NA). Both SUA and creatinine were significantly higher in the non-NA group than those in the NA group ((318.89 +/- 107.52) vs. (283.44 +/- 88.64) mu mol/L, and (95.08 +/- 53.24) vs. (79.63 +/- 18.20) mu mol/L, respectively). Logistic regression analysis showed that diabetic duration, systolic blood pressure, creatinine and SUA were the independent predictors of albuminuria. Furthermore, to identify the factors associated with renal function, these patients were divided into two groups according to the MDRD level (MDRD<90 or MDRD >= 90). Both SUA and creatinine were significantly higher in the lower MDRD group than those in the higher MDRD group ((301.90 +/- 96.46) vs. (264.07 +/- 84.74) mu mol/L, and (89.10 +/- 31.00) vs. (66.37 +/- 11.15) mu mol/L, respectively). Logistic. regression analysis showed that only age and SUA were the independent predictors of MDRD.

Conclusion High-normal SUA was associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients. Chin Med J 2011;124(22):3629-3634

语种英语
WOS记录号WOS:000297658300006
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61878
Collection北京大学第二临床医学院
北京大学第二临床医学院_内分泌科
作者单位Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Cai Xiao-ling,Han Xue-yao,Ji Li-nong. High-normal serum uric acid is associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients[J]. CHINESE MEDICAL JOURNAL,2011,124(22):3629-3634.
APA Cai Xiao-ling,Han Xue-yao,&Ji Li-nong.(2011).High-normal serum uric acid is associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients.CHINESE MEDICAL JOURNAL,124(22),3629-3634.
MLA Cai Xiao-ling,et al."High-normal serum uric acid is associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients".CHINESE MEDICAL JOURNAL 124.22(2011):3629-3634.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Cai Xiao-ling]'s Articles
[Han Xue-yao]'s Articles
[Ji Li-nong]'s Articles
百度学术
百度学术Similar articles in
[Cai Xiao-ling]'s Articles
[Han Xue-yao]'s Articles
[Ji Li-nong]'s Articles
必应学术
必应学术Similar articles in
[Cai Xiao-ling]'s Articles
[Han Xue-yao]'s Articles
[Ji Li-nong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.