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学科主题: 临床医学
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High-normal serum uric acid is associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients
作者: Cai Xiao-ling; Han Xue-yao; Ji Li-nong
关键词: serum uric acid ; estimated glomerular filtration rate ; albumin-to-creatinine ; type 2 diabetes
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-11-20
DOI: 10.3760/cma.j.issn.0366-6999.2011.22.006
卷: 124, 期:22, 页:3629-3634
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: BLOOD-PRESSURE ; RENAL-DISEASE ; INDEPENDENT MECHANISM ; HYPERURICEMIA ; MICROALBUMINURIA ; HYPERTENSION ; PROGRESSION ; MELLITUS ; CELLS
英文摘要:

Background Recently, some studies had shown that elevated serum uric acid (SUA) itself may increase the risk for development of renal disease in patients with diabetes. This study aimed to explore whether SUA was a predictor of microalbuminuria and impaired renal function in type 2 diabetes in Chinese patients.

Methods This cross-sectional study included 2108 type 2 diabetic patients. Kidney function was estimated using the simplified modification of diet in renal disease (MDRD) equation to obtain estimated glomerular filtration rate. The urine samples were obtained for measuring the albumin-to-creatinine ratio (ACR).

Results According to the ACR level, these patients were divided into two groups, normal ACR (NA) and non-normal ACR (non-NA). Both SUA and creatinine were significantly higher in the non-NA group than those in the NA group ((318.89 +/- 107.52) vs. (283.44 +/- 88.64) mu mol/L, and (95.08 +/- 53.24) vs. (79.63 +/- 18.20) mu mol/L, respectively). Logistic regression analysis showed that diabetic duration, systolic blood pressure, creatinine and SUA were the independent predictors of albuminuria. Furthermore, to identify the factors associated with renal function, these patients were divided into two groups according to the MDRD level (MDRD<90 or MDRD >= 90). Both SUA and creatinine were significantly higher in the lower MDRD group than those in the higher MDRD group ((301.90 +/- 96.46) vs. (264.07 +/- 84.74) mu mol/L, and (89.10 +/- 31.00) vs. (66.37 +/- 11.15) mu mol/L, respectively). Logistic. regression analysis showed that only age and SUA were the independent predictors of MDRD.

Conclusion High-normal SUA was associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients. Chin Med J 2011;124(22):3629-3634

语种: 英语
WOS记录号: WOS:000297658300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61878
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China

Recommended Citation:
Cai Xiao-ling,Han Xue-yao,Ji Li-nong. High-normal serum uric acid is associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients[J]. CHINESE MEDICAL JOURNAL,2011,124(22):3629-3634.
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