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学科主题: 临床医学
题名:
SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60
作者: Shi, Yu-Qiang1; Zhuang, Xin-Jie1,2; Xu, Bo3,4; Hua, Juan3,4; Liao, Shang-Ying1; Shi, Qinghua3,4; Cooke, Howard J.5; Han, Chunsheng1
关键词: SLX2 ; SYCE2 ; KAT/TIP60 ; gamma H2AX ; Meiosis
刊名: GENE
发表日期: 2013-09-15
DOI: 10.1016/j.gene.2013.06.033
卷: 527, 期:1, 页:352-359
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: GENE FAMILY XLR ; CYTOPLASMIC PROTEIN ; MEIOSIS ; MOUSE ; CHROMOSOME ; ENCODES ; H2AX ; XMR ; PHOSPHORYLATION ; ACETYLATION
英文摘要:

Meiosis is the process by which diploid germ cells produce haploid gametes. A key event is the formation of the synaptonemal complex. In the pachytene stage, the unpaired regions of X and Y chromosomes form a specialized structure, the XY body, within which gene expression is mostly silenced. In the present study, we showed that SYCP3-like X-linked 2 (SLX2, 1700013H16Rik), a novel member of XLR (X-linked Lymphocyte-Regulated) family, was specifically expressed in meiotic germ cells. In the spermatocyte SLX2 was distributed in the nucleus of germ cells at the preleptotene, leptotene and zygotene stages and is then restricted to the XY body at the pachytene stage. This localization change is coincident with that of phosphorylated histone H2AX (gamma H2AX), a well-known component of the sex body. Through yeast two-hybrid screening and coimmunoprecipitation assays, we demonstrated that SLX2 interacts with synaptonemal complex central element protein 2 (SYCE2), an important component of synaptonemal complex, and histone acetyltransferase TIP60, which has been implicated in remodeling phospho-H2AX-containing nucleosomes at sites of DNA damage. These results suggest that SLX2 might be involved in DNA recombination, synaptonemal complex formation as well as sex body maintenance during meiosis. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012CB966702 ; 2013CB945000 ; 31271379
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000323589100048
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61879
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China
2.Peking Univ, Ctr Reprod Med, Dept Obstet Gynecol, Hosp 3, Beijing 100191, Peoples R China
3.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China
4.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China
5.Western Gen Hosp, Inst Genet & Mol Med, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

Recommended Citation:
Shi, Yu-Qiang,Zhuang, Xin-Jie,Xu, Bo,et al. SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60[J]. GENE,2013,527(1):352-359.
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