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Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents
Zhang, Qingyou2; Jin, Hongfang2; Wang, Li2; Chen, Flanjun2; Tang, Chaoshu3; Du, Junbao2
关键词metoprolol syncope children and adolescents
刊名MEDICAL SCIENCE MONITOR
2008-04-01
14期:4页:CR199-CR203
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]NEURALLY-MEDIATED SYNCOPE ; NEUROCARDIOGENIC SYNCOPE ; UNEXPLAINED SYNCOPE ; BLOCKER THERAPY ; OF-CARDIOLOGY ; DOUBLE-BLIND ; TILT ; EFFICACY ; TRIAL ; YOUNG
英文摘要

Background: Previous studies that have assessed the effects of beta blockers on preventing vasovagal syncope provide conflicting results. We sought to evaluate the effectiveness of metoprolol versus conventional treatment in preventing the recurrence of syncope in children and adolescents.

Material/Methods: Twenty-eight children and adloscents (8 boys, 20 girls; mean age, 12 +/- 3 years; age range, 8-17 years) with vasovagal syncope were randomized to receive either metoprolol (metoprolol group; dosage range, 0.5-1.5 mg/kg/d) or conventional treatment (control group) for 1 year. The main outcome measure was the first recurrence of syncope beginning 2 weeks after the start of treatment. The mean follow-up was 22 +/- 10 months. Time of first recurrence of syncope was analyzed using Kaplan-Meier curves and compared with a log-rank test.

Results: The 2 groups did not differ in terms of clinical characteristics. The number of syncopal episodes before tilt testing was 8 +/- 6 in patients in the metoprolol group and 9 +/- 6 in patients in the control group (P=0.150). Syncope recurred in 6 of 14 children in the metoprolol gropu and in 4 of 14 children in the control group. No significant between-group differences were found regarding the probability of freedom from a recurrent episode of syncope during follow-up (metoprolol vs controls, 43% vs 29%, P=0.389), as demostrated by Kalpan-Meier curve analyses.

Conclusions: Recurrence of vasovagal syncope in children and adolescents treated with metoprolol is similar to that of patients treated with conventional therapy.

语种英语
WOS记录号WOS:000255086800008
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61882
专题北京大学第一临床医学院_儿科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Cardiovasc Res Inst, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Qingyou,Jin, Hongfang,Wang, Li,et al. Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents[J]. MEDICAL SCIENCE MONITOR,2008,14(4):CR199-CR203.
APA Zhang, Qingyou,Jin, Hongfang,Wang, Li,Chen, Flanjun,Tang, Chaoshu,&Du, Junbao.(2008).Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents.MEDICAL SCIENCE MONITOR,14(4),CR199-CR203.
MLA Zhang, Qingyou,et al."Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents".MEDICAL SCIENCE MONITOR 14.4(2008):CR199-CR203.
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