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学科主题: 公共卫生
题名:
Relationship between antibacterial activity of chitosan and surface characteristics of cell wall
作者: Chung, YC; Su, YP; Chen, CC; Jia, G; Wang, HI; Wu, JCG; Lin, JG
关键词: anti-bacterial agents ; chitosan ; cell wall
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004-07-01
卷: 25, 期:7, 页:932-936
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CHITIN ; PATHOGENS
英文摘要:

AIM: Five representative waterborne pathogens were used to illustrate the relationship between chitosan′s antibacterial activity and the surface characteristics of the bacterial cell wall. METHODS: Chitosan was prepared with averaged 75 % or 95 % deacetylated degree to examine its antibacterial activity against waterborne pathogens. Fresh microbial inoculants for the antibacterial assessment were prepared on nutrient agar at 37 degreesC for 24 h. The evaluation items of antibacterial mechanism included hydrophilicity and negative charge analysis of cell surface, and adsorptive characteristics of chitosan to bacterial cell. All the experiments were applied in triplicate tests at least. RESULTS: Although cell wall hydrophilicity was similar among Gram-negative bacteria, the distribution of negative charge on their cell surfaces was quite different. More negatively charged cell surfaces had a greater interaction with chitosan, a phenomenon further confirmed by transmission electron micrography (TEM). CONCLUSION: Results showed the hydrophilicity in Gram-negative bacteria was much higher than in Gram-positive ones. The correlation coefficient 0.988 between the amount of absorbed chitosan and its inhibition efficiency indicated a close relationship.

语种: 英语
WOS记录号: WOS:000222574700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61886
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.China Inst Technol, Dept Ind Engn & Management, Taipei 245, Taiwan
2.Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan
3.Fooyin Univ, Basic Med Sci Educ Ctr, Kaohsiung 831, Taiwan
4.Natl Taichung Nursing Coll, Dept Gen Studies, Taichung 403, Taiwan
5.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
6.China Med Univ, Inst Chinese Med Sci, Taichung 404, Taiwan

Recommended Citation:
Chung, YC,Su, YP,Chen, CC,et al. Relationship between antibacterial activity of chitosan and surface characteristics of cell wall[J]. ACTA PHARMACOLOGICA SINICA,2004,25(7):932-936.
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