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Relationship between antibacterial activity of chitosan and surface characteristics of cell wall
Chung, YC; Su, YP; Chen, CC; Jia, G; Wang, HI; Wu, JCG; Lin, JG
关键词anti-bacterial agents chitosan cell wall
刊名ACTA PHARMACOLOGICA SINICA
2004-07-01
25期:7页:932-936
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CHITIN ; PATHOGENS
英文摘要

AIM: Five representative waterborne pathogens were used to illustrate the relationship between chitosan′s antibacterial activity and the surface characteristics of the bacterial cell wall. METHODS: Chitosan was prepared with averaged 75 % or 95 % deacetylated degree to examine its antibacterial activity against waterborne pathogens. Fresh microbial inoculants for the antibacterial assessment were prepared on nutrient agar at 37 degreesC for 24 h. The evaluation items of antibacterial mechanism included hydrophilicity and negative charge analysis of cell surface, and adsorptive characteristics of chitosan to bacterial cell. All the experiments were applied in triplicate tests at least. RESULTS: Although cell wall hydrophilicity was similar among Gram-negative bacteria, the distribution of negative charge on their cell surfaces was quite different. More negatively charged cell surfaces had a greater interaction with chitosan, a phenomenon further confirmed by transmission electron micrography (TEM). CONCLUSION: Results showed the hydrophilicity in Gram-negative bacteria was much higher than in Gram-positive ones. The correlation coefficient 0.988 between the amount of absorbed chitosan and its inhibition efficiency indicated a close relationship.

语种英语
WOS记录号WOS:000222574700013
引用统计
被引频次:269[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61886
专题北京大学公共卫生学院
作者单位1.China Inst Technol, Dept Ind Engn & Management, Taipei 245, Taiwan
2.Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan
3.Fooyin Univ, Basic Med Sci Educ Ctr, Kaohsiung 831, Taiwan
4.Natl Taichung Nursing Coll, Dept Gen Studies, Taichung 403, Taiwan
5.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
6.China Med Univ, Inst Chinese Med Sci, Taichung 404, Taiwan
推荐引用方式
GB/T 7714
Chung, YC,Su, YP,Chen, CC,et al. Relationship between antibacterial activity of chitosan and surface characteristics of cell wall[J]. ACTA PHARMACOLOGICA SINICA,2004,25(7):932-936.
APA Chung, YC.,Su, YP.,Chen, CC.,Jia, G.,Wang, HI.,...&Lin, JG.(2004).Relationship between antibacterial activity of chitosan and surface characteristics of cell wall.ACTA PHARMACOLOGICA SINICA,25(7),932-936.
MLA Chung, YC,et al."Relationship between antibacterial activity of chitosan and surface characteristics of cell wall".ACTA PHARMACOLOGICA SINICA 25.7(2004):932-936.
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