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Ga-68-PRGD2 PET/CT in the Evaluation of Glioma: A Prospective Study
Li, Deling1,2,3; Zhao, Xiaobin4,5; Zhang, Liwei1,2,3; Li, Fang4,5; Ji, Nan1,2,3; Gao, Zhixian1,2,3; Wang, Jisheng1,2,3; Kang, Peng1,2,3; Liu, Zhaofei6; Shi, Jiyun6; Chen, Xiaoyuan7; Zhu, Zhaohui4,5
关键词integrin alpha(v)beta(3) glioma Ga-68 PET/CT
刊名MOLECULAR PHARMACEUTICS
2014-11-01
DOI10.1021/mp5003224
11期:11页:3923-3929
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]INTEGRIN ALPHA(V)BETA(3) EXPRESSION ; BRAIN-TUMORS ; PHASE-II ; CILENGITIDE ; GLIOBLASTOMA ; GRADE ; ALPHA-V-BETA-3 ; THERAPY ; GROWTH ; CELLS
英文摘要

Integrin alpha(v)beta 3 is overexpressed in both neovasculature and glioma cells. We aimed to evaluate (68)gallium-BNOTA-PRGD(2) (Ga-68-PRGD2) as a new reagent for noninvasive integrin alpha(v)beta(3) imaging in glioma patients. With informed consent, 12 patients with suspicious brain glioma, as diagnosed by enhanced magnetic resonance imaging (MRI) scanning, were enrolled to undergo Ga-68-PRGD2 PET/CT and F-18-FDG PET/CT scans before surgery. The preoperative images were compared and correlated with the pathologically determined WHO grade. Next, the expression of integrin alpha(v)beta(3), CD34, and Ki-67 were determined by immunohistochemical staining of the resected brain tumor tissue. Our findings demonstrated that Ga-68-PRGD2 specifically accumulated in the brain tumors that were rich of integrin alpha(v)beta(3) and other neovasculature markers, but not in the brain parenchyma other than the choroid plexus. Therefore, Ga-68-PRGD2 PET/CT was able to evaluate the glioma demarcation more specifically than F-18-FDG PET/CT. The maximum standardized uptake values (SUVmax) of Ga-68-PRGD2, rather than those of F-18-FDG, were significantly correlated with the glioma grading. The maximum tumor-to-brain ratios (TBRmax) of both tracers were significantly correlated with glioma grading, whereas Ga-68-PRGD2 seemed to be more superior to F-18-FDG in differentiating high-grade glioma (HGG) from low-grade glioma (LGG). Moreover, Ga-68-PRGD2 PET/CT showed different accumulation patterns for HGG of WHO grades III and IV. This is the first noninvasive integrin imaging study, to the best of our knowledge, conducted in preoperative patients with different grades of glioma, and it preliminarily indicated the effectiveness of this novel method for evaluating glioma grading and demarcation.

语种英语
WOS记录号WOS:000344307700016
项目编号2011YQ17006710 ; 2013CB733802 ; 2014CB744503 ; 81171370 ; 81271614 ; 81371596 ; Z121107001012119
资助机构National Key Scientific Instrument and Equipment Development Project ; Major State Basic Research Development Program of China (973 Program) ; National Natural Science Foundation of China ; Capital Special Project for Featured Clinical Application ; Beijing Key Laboratory of Brian Tumor Project ; National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61887
专题北京大学医药卫生分析中心
北京大学基础医学院
作者单位1.China Natl Clin Res Ctr Neurol Dis, NCRC ND, Beijing, Peoples R China
2.Beijing Key Lab Brian Tumor, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
5.Peking Union Med Coll, Beijing 100021, Peoples R China
6.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China
7.NIBIB, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA
推荐引用方式
GB/T 7714
Li, Deling,Zhao, Xiaobin,Zhang, Liwei,et al. Ga-68-PRGD2 PET/CT in the Evaluation of Glioma: A Prospective Study[J]. MOLECULAR PHARMACEUTICS,2014,11(11):3923-3929.
APA Li, Deling.,Zhao, Xiaobin.,Zhang, Liwei.,Li, Fang.,Ji, Nan.,...&Zhu, Zhaohui.(2014).Ga-68-PRGD2 PET/CT in the Evaluation of Glioma: A Prospective Study.MOLECULAR PHARMACEUTICS,11(11),3923-3929.
MLA Li, Deling,et al."Ga-68-PRGD2 PET/CT in the Evaluation of Glioma: A Prospective Study".MOLECULAR PHARMACEUTICS 11.11(2014):3923-3929.
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