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学科主题: 临床医学
题名:
Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats
作者: Liu, Jing1; Zhou, Feng2; Li, Guang-Yong3; Wang, Lin1; Li, Hui-Xi1; Bai, Guang-Yi1; Guan, Rui-Li1; Xu, Yong-De1; Gao, Ze-Zhu1; Tian, Wen-Jie4; Xin, Zhong-Cheng1
关键词: erectile dysfunction ; diabetes mellitus ; low energy shock wave therapy ; corpus cavernosum
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2013-05-01
DOI: 10.3390/ijms140510661
卷: 14, 期:5, 页:10661-10673
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: DOUBLE-BLIND ; DYSFUNCTION ; MODEL ; MELLITUS ; DISEASE ; MEN
英文摘要:

To investigate the therapeutic effect of different doses of low energy shock wave therapy (LESWT) on the erectile dysfunction (ED) in streptozotocin (STZ) induced diabetic rats. SD rats (n = 75) were randomly divided into 5 groups (normal control, diabetic control, 3 different dose LESWT treated diabetic groups). Diabetic rats were induced by intra-peritoneal injection of STZ (60 mg/kg) and rats with fasting blood glucose = 300 mg/dL were selected as diabetic models. Twelve weeks later, different doses of LESWT (100, 200 and 300 shocks each time) treatment on penises were used to treat ED (7.33 MPa, 2 shocks/s) three times a week for two weeks. The erectile function was evaluated by intracavernous pressure (ICP) after 1 week washout period. Then the penises were harvested for histological study. The results showed LESWT could significantly improve the erectile function of diabetic rats, increase smooth muscle and endothelial contents, up-regulate the expression of alpha-SMA, vWF, nNOS and VEGF, and down-regulate the expression of RAGE in corpus cavernosum. The therapeutic effect might relate to treatment dose positively, and the maximal therapeutic effect was noted in the LESWT300 group. Consequently, 300 shocks each time might be the ideal LESWT dose for diabetic ED treatment.

语种: 英语
所属项目编号: 81270693 ; 81272531
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000319441500110
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61903
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
2.Soochow Univ, Affiliated Hosp 1, Dept Urol, Suzhou 215006, Jiangsu, Peoples R China
3.Ningxia Med Univ, Gen Hosp, Dept Urol, Ningxia 750004, Peoples R China
4.Jilin Univ, China Japan Union Hosp, Dept Urol, Changchun 130033, Jilin, Peoples R China

Recommended Citation:
Liu, Jing,Zhou, Feng,Li, Guang-Yong,et al. Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(5):10661-10673.
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