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Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats
Liu, Jing1; Zhou, Feng2; Li, Guang-Yong3; Wang, Lin1; Li, Hui-Xi1; Bai, Guang-Yi1; Guan, Rui-Li1; Xu, Yong-De1; Gao, Ze-Zhu1; Tian, Wen-Jie4; Xin, Zhong-Cheng1
关键词erectile dysfunction diabetes mellitus low energy shock wave therapy corpus cavernosum
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2013-05-01
DOI10.3390/ijms140510661
14期:5页:10661-10673
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]DOUBLE-BLIND ; DYSFUNCTION ; MODEL ; MELLITUS ; DISEASE ; MEN
英文摘要

To investigate the therapeutic effect of different doses of low energy shock wave therapy (LESWT) on the erectile dysfunction (ED) in streptozotocin (STZ) induced diabetic rats. SD rats (n = 75) were randomly divided into 5 groups (normal control, diabetic control, 3 different dose LESWT treated diabetic groups). Diabetic rats were induced by intra-peritoneal injection of STZ (60 mg/kg) and rats with fasting blood glucose = 300 mg/dL were selected as diabetic models. Twelve weeks later, different doses of LESWT (100, 200 and 300 shocks each time) treatment on penises were used to treat ED (7.33 MPa, 2 shocks/s) three times a week for two weeks. The erectile function was evaluated by intracavernous pressure (ICP) after 1 week washout period. Then the penises were harvested for histological study. The results showed LESWT could significantly improve the erectile function of diabetic rats, increase smooth muscle and endothelial contents, up-regulate the expression of alpha-SMA, vWF, nNOS and VEGF, and down-regulate the expression of RAGE in corpus cavernosum. The therapeutic effect might relate to treatment dose positively, and the maximal therapeutic effect was noted in the LESWT300 group. Consequently, 300 shocks each time might be the ideal LESWT dose for diabetic ED treatment.

语种英语
WOS记录号WOS:000319441500110
项目编号81270693 ; 81272531
资助机构National Natural Science Foundation of China
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被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61903
专题北京大学第一临床医学院_男科中心
作者单位1.Peking Univ, Peking Univ Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
2.Soochow Univ, Affiliated Hosp 1, Dept Urol, Suzhou 215006, Jiangsu, Peoples R China
3.Ningxia Med Univ, Gen Hosp, Dept Urol, Ningxia 750004, Peoples R China
4.Jilin Univ, China Japan Union Hosp, Dept Urol, Changchun 130033, Jilin, Peoples R China
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Liu, Jing,Zhou, Feng,Li, Guang-Yong,et al. Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(5):10661-10673.
APA Liu, Jing.,Zhou, Feng.,Li, Guang-Yong.,Wang, Lin.,Li, Hui-Xi.,...&Xin, Zhong-Cheng.(2013).Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,14(5),10661-10673.
MLA Liu, Jing,et al."Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14.5(2013):10661-10673.
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