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学科主题: 临床医学
题名:
Langerhans cell histiocytosis with multiple spinal involvement
作者: Jiang, Liang1; Liu, Xiao Guang1; Zhong, Wo Quan1; Ma, Qing Jun1; Wei, Feng1; Yuan, Hui Shu2; Dang, Geng Ting1; Liu, Zhong Jun1
关键词: Langerhans cell histiocytosis ; Spine ; Multifocal disease ; Biopsy ; Treatment
刊名: EUROPEAN SPINE JOURNAL
发表日期: 2011-11-01
DOI: 10.1007/s00586-010-1390-1
卷: 20, 期:11, 页:1961-1969
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Orthopedics
研究领域[WOS]: Neurosciences & Neurology ; Orthopedics
关键词[WOS]: TERM-FOLLOW-UP ; EOSINOPHILIC GRANULOMA ; CERVICAL-SPINE ; CHILDREN ; EXPERIENCE ; MANAGEMENT
英文摘要:

To stress the clinical and radiologic presentation and treatment outcome of Langerhans cell histiocytosis (LCH) with multiple spinal involvements. A total of 42 cases with spinal LCH were reviewed in our hospital and 5 had multifocal spinal lesions. Multiple spinal LCH has been reported in 50 cases in the literature. All cases including ours were analyzed concerning age, sex, clinical and radiologic presentation, therapy and outcome. Of our five cases, three had neurological symptom, four soft tissue involvement and three had posterior arch extension. Compiling data from the eight largest case series of the spinal LCH reveals that 27.2% multiple vertebrae lesions. In these 55 cases, there were 26 female and 29 male with the mean age of 7.4 years (range 0.2-37). A total of 182 vertebrae were involved including 28.0% in the cervical spine, 47.8% in thoracic and 24.2% in the lumbar spine. Extraspinal LCH lesion was documented in 54.2% cases, visceral involvement in 31.1% and vertebra plana in 50% cases. Paravertebral and epidural extension were not documented in most cases. Pathological diagnosis was achieved in 47 cases including 8 open spine biopsy. The treatment strategy varied depending on different hospitals. One patient died, two had recurrence and the others had no evidence of the disease with an average of 7.2 years (range 1-21) of follow-up. Asymptomatic spinal lesions could be simply observed with or without bracing and chemotherapy is justified for multiple lesions. Surgical decompression should be reserved for the uncommon cases in which neurologic compromise does not respond to radiotherapy or progresses too rapidly for radiotherapy.

语种: 英语
WOS记录号: WOS:000296295600021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61911
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China

Recommended Citation:
Jiang, Liang,Liu, Xiao Guang,Zhong, Wo Quan,et al. Langerhans cell histiocytosis with multiple spinal involvement[J]. EUROPEAN SPINE JOURNAL,2011,20(11):1961-1969.
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