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学科主题: 药学
题名:
HPLC-DAD-MSn analysis and HPLC quantitation of chemical constituents in the traditional Chinese medicine formula Ya-tong-yi-li-wan
作者: Liu, Ke-di; Qiao, Xue; Wang, Qing; Song, Wei; Guo, De-an; Ye, Min
刊名: ANALYTICAL METHODS
发表日期: 2013
DOI: 10.1039/c3ay41054d
卷: 5, 期:19, 页:5241-5247
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Food Science & Technology ; Spectroscopy
研究领域[WOS]: Chemistry ; Food Science & Technology ; Spectroscopy
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; TANDEM MASS-SPECTROMETRY ; GLYCYRRHIZA-URALENSIS ; BUFADIENOLIDES ; LICORICE ; IDENTIFICATION ; CHANSU
英文摘要:

A combination of qualitative and quantitative methods was developed and validated to elucidate the chemical constituents in Ya-tong-yi-li-wan (YTYLW), a traditional Chinese medicine formula used for the treatment of toothache in China. Few reports are available on the chemical analysis of YTYLW, so far. For qualitative analysis, a method based on high-performance liquid chromatography coupled with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC/DAD/ESI-MSn) was established. A total of 48 compounds in YTYLW were characterized, including 10 bufadienolides, 9 isoflavones, 7 chalcones, 7 saponins, 6 flavanones, 4 flavonols, 2 flavones, 2 coumarins, and 1 pterocarpan. For quantitative analysis, 12 major compounds in YTYLW were simultaneously determined by HPLC-UV at 270 nm in 9 batches of commercial products. Precision, reproducibility and accuracy of the method were fully validated. The method established in this study could be used for the quality control of YTYLW.

语种: 英语
所属项目编号: 81173644 ; 81222054 ; NCET-11-0019
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University from China Ministry of Education
WOS记录号: WOS:000324489100041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61912
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Ke-di,Qiao, Xue,Wang, Qing,et al. HPLC-DAD-MSn analysis and HPLC quantitation of chemical constituents in the traditional Chinese medicine formula Ya-tong-yi-li-wan[J]. ANALYTICAL METHODS,2013,5(19):5241-5247.
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