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学科主题: 临床医学
题名:
NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence
作者: Liu, Kaiyu1; Jin, Bo2; Wu, Chenglin3; Yang, Jianming1; Zhan, Xiangwen1; Wang, Le1; Shen, Xiaomeng1; Chen, Jing1; Chen, Hao1; Mao, Zebin1
关键词: NQO1 ; p53 ; senescence
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
发表日期: 2015
DOI: 10.7150/ijbs.11978
卷: 11, 期:7, 页:762-771
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
关键词[WOS]: OXIDOREDUCTASE(1) DT-DIAPHORASE ; CELLULAR SENESCENCE ; PROTEASOMAL DEGRADATION ; HUMAN FIBROBLASTS ; HETEROCHROMATIN FORMATION ; TUMOR SUPPRESSION ; ACTIVATION ; EXPRESSION ; CANCER ; CELLS
英文摘要:

Cellular senescence is a state of permanent cellular arrest that provides an initial barrier to cell transformation and tumorigenesis. In this study, we report that expression of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoplasmic 2-electron reductase, is induced during oncogene-induced senescence (OIS). Depletion of NQO1 resulted in the delayed onset of senescence. In contrast, ectopic expression of NQO1 enhanced the senescence phenotype. Analysis of the mechanism underlying the up-regulation of NQO1 expression during senescence identified that NQO1 promotes p53 accumulation in an MDM2 and ubiquitin independent manner, which reinforces the cellular senescence phenotype. Specifically, we demonstrated that NRF2/KEAP1 signaling regulates NQO1 expression during OIS. More importantly, we confirmed that depletion of NQO1 facilitates cell transformation and tumorigenesis, which indicates that NQO1 takes part in the senescence barrier and has anti-oncogenic properties in cell transformation.

语种: 英语
所属项目编号: 2013CB530801 ; 2011CB966203 ; 81471406
项目资助者: National Basic Research Programs of China ; Natural Science Foundation of China
WOS记录号: WOS:000359007700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61928
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
3.Navy Gen Hosp, Ctr Basic Med Sci, Beijing 100048, Peoples R China

Recommended Citation:
Liu, Kaiyu,Jin, Bo,Wu, Chenglin,et al. NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2015,11(7):762-771.
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