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NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence
Liu, Kaiyu1; Jin, Bo2; Wu, Chenglin3; Yang, Jianming1; Zhan, Xiangwen1; Wang, Le1; Shen, Xiaomeng1; Chen, Jing1; Chen, Hao1; Mao, Zebin1
关键词Nqo1 P53 Senescence
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
2015
DOI10.7150/ijbs.11978
11期:7页:762-771
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
关键词[WOS]Oxidoreductase(1) Dt-diaphorase ; Cellular Senescence ; Proteasomal Degradation ; Human Fibroblasts ; Heterochromatin Formation ; Tumor Suppression ; Activation ; Expression ; Cancer ; Cells
英文摘要

Cellular senescence is a state of permanent cellular arrest that provides an initial barrier to cell transformation and tumorigenesis. In this study, we report that expression of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoplasmic 2-electron reductase, is induced during oncogene-induced senescence (OIS). Depletion of NQO1 resulted in the delayed onset of senescence. In contrast, ectopic expression of NQO1 enhanced the senescence phenotype. Analysis of the mechanism underlying the up-regulation of NQO1 expression during senescence identified that NQO1 promotes p53 accumulation in an MDM2 and ubiquitin independent manner, which reinforces the cellular senescence phenotype. Specifically, we demonstrated that NRF2/KEAP1 signaling regulates NQO1 expression during OIS. More importantly, we confirmed that depletion of NQO1 facilitates cell transformation and tumorigenesis, which indicates that NQO1 takes part in the senescence barrier and has anti-oncogenic properties in cell transformation.

语种英语
WOS记录号WOS:000359007700004
通讯作者邮箱zbmao@bjmu.edu.cn
项目编号2013CB530801 ; 2011CB966203 ; 81471406
资助机构National Basic Research Programs of China ; Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61928
专题北京大学第一临床医学院
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China
3.Navy Gen Hosp, Ctr Basic Med Sci, Beijing 100048, Peoples R China
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GB/T 7714
Liu, Kaiyu,Jin, Bo,Wu, Chenglin,et al. NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2015,11(7):762-771.
APA Liu, Kaiyu.,Jin, Bo.,Wu, Chenglin.,Yang, Jianming.,Zhan, Xiangwen.,...&Mao, Zebin.(2015).NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,11(7),762-771.
MLA Liu, Kaiyu,et al."NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 11.7(2015):762-771.
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