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A Preliminary Study on the Occurrence of Cytostatic Drugs in Hospital Effluents in Beijing, China
Yin, Jie2; Shao, Bing1; Zhang, Jing1; Li, Keji2
关键词Cytostatic drugs Occurrence Hospital effluents UPLC-ESI-MS/MS
刊名BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
2010
DOI10.1007/s00128-009-9884-4
84期:1页:39-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Toxicology
研究领域[WOS]Environmental Sciences & Ecology ; Toxicology
关键词[WOS]SOLID-PHASE EXTRACTION ; LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; SEWAGE WATER ; WASTE-WATER ; CYCLOPHOSPHAMIDE ; IFOSFAMIDE ; MUTAGENICITY ; FATE
英文摘要

Cytostatic drugs are used in cancer therapy. They can enter hospital wastewater due to excretion by patients undergoing chemotherapy. Little attention has been paid to these drugs in China even though their usage is high. The effluents of 21 hospitals of different size in Beijing, China, were investigated on 1-7 different days. Nine cytostatic compounds (methotrexate, azathioprine, doxorubicin, doxorubicinol, vincristine, ifosfamide, cyclophosphamide, etoposide, and procarbazine) were tested. Of the 65 effluent samples analyzed, the median concentrations for methotrexate, azathioprine, ifosfamide, cyclophosphamide and etoposide were 17, 15, 151, 100 and 42 ng/L, respectively. Doxorubicin, doxorubicinol, vincristine and procarbazine were not detected in this study. These results suggested that the hospital effluents are an important source of certain cytostatic drugs in aqueous environment.

语种英语
WOS记录号WOS:000273102500009
项目编号20607004
资助机构National Natural Science Foundation of China
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61930
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位1.Beijing Ctr Dis Control & Prevent, Cent Lab, Beijing 100013, Peoples R China
2.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Yin, Jie,Shao, Bing,Zhang, Jing,et al. A Preliminary Study on the Occurrence of Cytostatic Drugs in Hospital Effluents in Beijing, China[J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2010,84(1):39-45.
APA Yin, Jie,Shao, Bing,Zhang, Jing,&Li, Keji.(2010).A Preliminary Study on the Occurrence of Cytostatic Drugs in Hospital Effluents in Beijing, China.BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,84(1),39-45.
MLA Yin, Jie,et al."A Preliminary Study on the Occurrence of Cytostatic Drugs in Hospital Effluents in Beijing, China".BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 84.1(2010):39-45.
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