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学科主题: 公共卫生
题名:
A Preliminary Study on the Occurrence of Cytostatic Drugs in Hospital Effluents in Beijing, China
作者: Yin, Jie2; Shao, Bing1; Zhang, Jing1; Li, Keji2
关键词: Cytostatic drugs ; Occurrence ; Hospital effluents ; UPLC-ESI-MS/MS
刊名: BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
发表日期: 2010
DOI: 10.1007/s00128-009-9884-4
卷: 84, 期:1, 页:39-45
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Toxicology
研究领域[WOS]: Environmental Sciences & Ecology ; Toxicology
关键词[WOS]: SOLID-PHASE EXTRACTION ; LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; SEWAGE WATER ; WASTE-WATER ; CYCLOPHOSPHAMIDE ; IFOSFAMIDE ; MUTAGENICITY ; FATE
英文摘要:

Cytostatic drugs are used in cancer therapy. They can enter hospital wastewater due to excretion by patients undergoing chemotherapy. Little attention has been paid to these drugs in China even though their usage is high. The effluents of 21 hospitals of different size in Beijing, China, were investigated on 1-7 different days. Nine cytostatic compounds (methotrexate, azathioprine, doxorubicin, doxorubicinol, vincristine, ifosfamide, cyclophosphamide, etoposide, and procarbazine) were tested. Of the 65 effluent samples analyzed, the median concentrations for methotrexate, azathioprine, ifosfamide, cyclophosphamide and etoposide were 17, 15, 151, 100 and 42 ng/L, respectively. Doxorubicin, doxorubicinol, vincristine and procarbazine were not detected in this study. These results suggested that the hospital effluents are an important source of certain cytostatic drugs in aqueous environment.

语种: 英语
所属项目编号: 20607004
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000273102500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61930
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Beijing Ctr Dis Control & Prevent, Cent Lab, Beijing 100013, Peoples R China
2.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Yin, Jie,Shao, Bing,Zhang, Jing,et al. A Preliminary Study on the Occurrence of Cytostatic Drugs in Hospital Effluents in Beijing, China[J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2010,84(1):39-45.
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