IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas
Zhang Yun-gang; Du Juan; Tian Xin-xia; Zhong Yan-feng; Fang Wei-gang
关键词ductal breast carcinomas E-cadherin beta-catenin cathepsin D matrix metalloproteinase 2
刊名CHINESE MEDICAL JOURNAL
2007-09-20
120期:18页:1597-1605
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]PROGNOSTIC VALUE ; TISSUE INHIBITORS ; ALPHA-CATENIN ; CANCER-CELLS ; METASTASIS ; METALLOPROTEINASES ; SURVIVAL ; PROTEIN ; COMPLEX ; MMP-2
英文摘要

Background E-cadherin, beta-catenin, cathepsin D, matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 are all invasion-related proteins. The expression patterns of these proteins in invasive ductal breast carcinomas, and their associations with known clinicopathological parameters, tumor recurrence and expressions of estrogen receptor (ER), progesterone receptor (PR), PS2 and c-erbB2 were not well studied in Chinese patients.

Methods In a set of 94 invasive ductal breast carcinomas, protein expressions of these molecular markers were investigated by immunohistochemistry, and their associations with known clinicopathological parameters, tumor recurrence and expressions of ER, PR, PS2 and c-erbB2 were also examined. In addition, the interrelationship between the expressions of these proteins were studied.

Results Preserved membrane E-cadherin expression was associated with late tumor stage and tumor recurrence, whereas the reduced junctional beta-catenin associated with positive lymph node status and c-erbB2 overexpression. Positive staining of cathepsin D in tumor stromal cells displayed a significant association with late tumor stage. High expression of MMP-2 in cancer cells was associated with large tumor size and PR positive expression. TIMP-2 expression was positively associated with tumor recurrence. In addition, inter-relationship between the expressions of these biomarkers was also assessed. Cathepsin D staining in cancer cells was inversely correlated with its staining in stromal cells, and also inversely correlated with MMP-2 staining in tumor stromal cells. MMP-2 expression in stromal cells displayed an inverse correlation with TIMP-2 expression. MMP-9 expression displayed parallel associations with TIMP-1 and TIMP-2 expression.

Conclusion Evaluation of E-cadherin, beta-catenin, cathepsin D, MMP-2 and TIMP-2 expression may be of some help in more accurately predicting the prognosis of invasive ductal breast carcinomas.

语种英语
WOS记录号WOS:000249796300008
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61941
专题北京大学基础医学院_病理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang Yun-gang,Du Juan,Tian Xin-xia,et al. Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas[J]. CHINESE MEDICAL JOURNAL,2007,120(18):1597-1605.
APA Zhang Yun-gang,Du Juan,Tian Xin-xia,Zhong Yan-feng,&Fang Wei-gang.(2007).Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas.CHINESE MEDICAL JOURNAL,120(18),1597-1605.
MLA Zhang Yun-gang,et al."Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas".CHINESE MEDICAL JOURNAL 120.18(2007):1597-1605.
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