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学科主题: 临床医学
题名:
Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (Review)
作者: Ji, Jiafu1,2,3; Jia, Shuqin1,3,4; Ji, Ke1,4; Jiang, Wen G.1,4
关键词: Wnt1 inducible signalling pathway protein-2 ; CCN5 ; epithelial-mesenchymal transition ; angiogenesis ; cellular migration ; metastasis
刊名: ONCOLOGY REPORTS
发表日期: 2014-02-01
DOI: 10.3892/or.2013.2909
卷: 31, 期:2, 页:533-539
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HUMAN BREAST-CANCER ; TISSUE GROWTH-FACTOR ; TUMOR-CELL-PROLIFERATION ; MOLECULAR CROSS-TALKS ; ARREST-SPECIFIC GENE ; CCN FAMILY ; DIFFERENTIAL EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; PROGNOSTIC IMPLICATIONS ; CCN5/WISP-2 EXPRESSION
英文摘要:

Wnt1 inducible signalling pathway protein-2 (WISP-2), also known as CCN5, CT58, CTGF-L, CTGF-3, HICP and Cop1, is one of the 3 WNT1 inducible proteins that belongs to the CCN family. This family of members has been shown to play multiple roles in a number of pathophysiological processes, including cell proliferation, adhesion, wound healing, extracellular matrix regulation, epithelial-mesenchymal transition, angiogenesis, fibrosis, skeletal development and embryo implantation. Recent results suggest that WISP-2 is relevant to tumorigenesis and malignant transformation, particularly in breast cancer, colorectal cancer and hepatocarcinoma. Notably, its roles in cancer appear to vary depending on cell/tumour type and the microenvironment. The striking difference in the structure of WISP-2 in comparison with the other 2 family members may contribute to its difference in functions, which leads to the hypothesis that WISP-2 may act as a dominant-negative regulator of other CCN family members. In the present review, we summarise the roles, regulation and underlying mechanism of WISP-2 in human cancers.

语种: 英语
项目资助者: Cancer Research Wales ; Albert Hung Foundation ; Cardiff University
WOS记录号: WOS:000332694400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61943
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Joint Canc Inst, Cardiff Univ, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp, Dept Gastroenterol Canc, Beijing 100871, Peoples R China
3.Inner Mongolia Med Univ, Affiliated Hosp, Surg Lab, Hohhot, Peoples R China
4.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales

Recommended Citation:
Ji, Jiafu,Jia, Shuqin,Ji, Ke,et al. Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (Review)[J]. ONCOLOGY REPORTS,2014,31(2):533-539.
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