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Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (Review)
Ji, Jiafu1,2,3; Jia, Shuqin1,3,4; Ji, Ke1,4; Jiang, Wen G.1,4
关键词Wnt1 inducible signalling pathway protein-2 CCN5 epithelial-mesenchymal transition angiogenesis cellular migration metastasis
刊名ONCOLOGY REPORTS
2014-02-01
DOI10.3892/or.2013.2909
31期:2页:533-539
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HUMAN BREAST-CANCER ; TISSUE GROWTH-FACTOR ; TUMOR-CELL-PROLIFERATION ; MOLECULAR CROSS-TALKS ; ARREST-SPECIFIC GENE ; CCN FAMILY ; DIFFERENTIAL EXPRESSION ; HEPATOCELLULAR-CARCINOMA ; PROGNOSTIC IMPLICATIONS ; CCN5/WISP-2 EXPRESSION
英文摘要

Wnt1 inducible signalling pathway protein-2 (WISP-2), also known as CCN5, CT58, CTGF-L, CTGF-3, HICP and Cop1, is one of the 3 WNT1 inducible proteins that belongs to the CCN family. This family of members has been shown to play multiple roles in a number of pathophysiological processes, including cell proliferation, adhesion, wound healing, extracellular matrix regulation, epithelial-mesenchymal transition, angiogenesis, fibrosis, skeletal development and embryo implantation. Recent results suggest that WISP-2 is relevant to tumorigenesis and malignant transformation, particularly in breast cancer, colorectal cancer and hepatocarcinoma. Notably, its roles in cancer appear to vary depending on cell/tumour type and the microenvironment. The striking difference in the structure of WISP-2 in comparison with the other 2 family members may contribute to its difference in functions, which leads to the hypothesis that WISP-2 may act as a dominant-negative regulator of other CCN family members. In the present review, we summarise the roles, regulation and underlying mechanism of WISP-2 in human cancers.

语种英语
WOS记录号WOS:000332694400002
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61943
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位1.Peking Univ, Joint Canc Inst, Cardiff Univ, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp, Dept Gastroenterol Canc, Beijing 100871, Peoples R China
3.Inner Mongolia Med Univ, Affiliated Hosp, Surg Lab, Hohhot, Peoples R China
4.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales
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Ji, Jiafu,Jia, Shuqin,Ji, Ke,et al. Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (Review)[J]. ONCOLOGY REPORTS,2014,31(2):533-539.
APA Ji, Jiafu,Jia, Shuqin,Ji, Ke,&Jiang, Wen G..(2014).Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (Review).ONCOLOGY REPORTS,31(2),533-539.
MLA Ji, Jiafu,et al."Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (Review)".ONCOLOGY REPORTS 31.2(2014):533-539.
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