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学科主题基础医学
SERUM PROGRAMMED CELL DEATH PROTEIN 5 (PDCD5) LEVELS IS UPREGULATED IN LIVER DISEASES
Chen, Yingyu1,2; Zou, Zhiqiang3; Xu, Ailing3; Liu, Youde3; Pan, Huan2; Jin, Lei4
关键词Biomarker liver disease programmed cell death protein 5 sandwich ELISA
刊名JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY
2013-07-03
DOI10.1080/15321819.2012.731461
34期:3页:294-304
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Immunology ; Medical Laboratory Technology
研究领域[WOS]Biochemistry & Molecular Biology ; Immunology ; Medical Laboratory Technology
关键词[WOS]PROGNOSTIC-SIGNIFICANCE ; REDUCED EXPRESSION ; TOXOPLASMA-GONDII ; TUMOR-CELLS ; APOPTOSIS ; GENE ; OVEREXPRESSION ; CELL-DEATH-5 ; BIOMARKER ; MOLECULE
英文摘要

Intracellular protein molecules are detected in the blood following release from damaged cells. PDCD5 is widely expressed in most types of normal human tissue and is unregulated in cells undergoing apoptosis. It is therefore hypothesized that release of PDCD5 into the circulation might be a specific marker of apoptosis. In this study, a sandwich ELISA was developed for quantification of soluble PDCD5 protein and used to investigate serum PDCD5 levels in liver diseases. The highest levels of PDCD5 were detected in acute icteric hepatitis (AIH) patients compared with normal subjects and other detected liver diseases, such as chronic active hepatitis B (CAHB), chronic persistent hepatitis B (CPHB) and and liver cirrhosis (LC). Increased PDCD5 levels correlated well with ALT and AST in AIH and CAHB patients. In patients with CPHB, increased PDCD5 levels correlated well with AST, TBI, DBIL, and IBIL. In LC patients, PDCD5 levels correlated well with AST/ALT and DBIL. More importantly, increased PDCD5 levels were also observed in patients with normal ALT or AST levels. These data demonstrate a correlation between increased levels of PDCD5 in serum and liver disease progression and indicate the potential utility of serum PDCD5 as a biomarker for monitoring liver injury.

语种英语
WOS记录号WOS:000318591400007
项目编号2011CB910103 ; 30871263
资助机构National Key Project for Basic Research of China (973) ; National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61947
专题北京大学基础医学院_免疫学系
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位1.Yantai Infect Hosp, Yantai, Shandong, Peoples R China
2.Peking Univ, Key Lab Med Immunol, Minist Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
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GB/T 7714
Chen, Yingyu,Zou, Zhiqiang,Xu, Ailing,et al. SERUM PROGRAMMED CELL DEATH PROTEIN 5 (PDCD5) LEVELS IS UPREGULATED IN LIVER DISEASES[J]. JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY,2013,34(3):294-304.
APA Chen, Yingyu,Zou, Zhiqiang,Xu, Ailing,Liu, Youde,Pan, Huan,&Jin, Lei.(2013).SERUM PROGRAMMED CELL DEATH PROTEIN 5 (PDCD5) LEVELS IS UPREGULATED IN LIVER DISEASES.JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY,34(3),294-304.
MLA Chen, Yingyu,et al."SERUM PROGRAMMED CELL DEATH PROTEIN 5 (PDCD5) LEVELS IS UPREGULATED IN LIVER DISEASES".JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY 34.3(2013):294-304.
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