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学科主题临床医学
Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality
Chen, Fan1,2; Lv, Min3; Xue, Yun4; Zhou, Jing5; Hu, Feifei1; Chen, Xin1; Zhao, Zhanqin4; Li, Yang1; Wang, XingGuo1
关键词FGFR2 Breast cancer SNP Han nationality
刊名IMMUNOGENETICS
2012
DOI10.1007/s00251-011-0564-2
64期:1页:71-76
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Immunology
研究领域[WOS]Genetics & Heredity ; Immunology
关键词[WOS]GENOME-WIDE ASSOCIATION ; SUSCEPTIBILITY ; COHORT ; BRCA1
英文摘要

Fibroblast growth factor receptor 2 (FGFR2), a recently described risk factor for breast cancer, plays important roles in cell growth, invasiveness, motility, and angiogenesis. In attempt to investigate whether FGFR2 polymorphisms are associated with a risk of breast cancer in Chinese women of the Han nationality, we genotyped single-nucleotide polymorphisms (SNPs) of seven FGFR2 sites (rs2981582, rs17102287, rs17542768, rs10510097, rs11200012, rs3750817, rs2981578) in 816 women including 388 breast cancer patients and 428 healthy controls via the polymerase chain reaction single-strand conformation polymorphism procedure as well as sequence detection. Our results suggest that the A allele and AA genotype of SNP rs2981578 appear to be protective factors associated with breast cancer, while the CT genotype of SNP rs3750817 is a putative risk factor.

语种英语
WOS记录号WOS:000300831200008
项目编号30801014 ; 31001051 ; Q20091001
资助机构National Natural Science Foundation of China ; Department of Education of Hubei Province
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61948
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.Hubei Univ, Sch Life Sci, Wuhan 430062, Peoples R China
2.Hainan Med Coll, Hainan Prov Key Lab Trop Med, Haikou 571101, Peoples R China
3.Peking Univ, Dept Med Oncol, Key Lab Carcinogenesis & Translat Res, Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Henan Univ Sci & Techol, Med Engn Lab, Coll Med Technol & Engn, Luoyang 471003, Peoples R China
5.Wuhan TB Dispensary, Wuhan 430030, Peoples R China
推荐引用方式
GB/T 7714
Chen, Fan,Lv, Min,Xue, Yun,et al. Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality[J]. IMMUNOGENETICS,2012,64(1):71-76.
APA Chen, Fan.,Lv, Min.,Xue, Yun.,Zhou, Jing.,Hu, Feifei.,...&Wang, XingGuo.(2012).Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality.IMMUNOGENETICS,64(1),71-76.
MLA Chen, Fan,et al."Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality".IMMUNOGENETICS 64.1(2012):71-76.
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