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学科主题: 临床医学
题名:
Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality
作者: Chen, Fan1,2; Lv, Min3; Xue, Yun4; Zhou, Jing5; Hu, Feifei1; Chen, Xin1; Zhao, Zhanqin4; Li, Yang1; Wang, XingGuo1
关键词: FGFR2 ; Breast cancer ; SNP ; Han nationality
刊名: IMMUNOGENETICS
发表日期: 2012
DOI: 10.1007/s00251-011-0564-2
卷: 64, 期:1, 页:71-76
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Immunology
研究领域[WOS]: Genetics & Heredity ; Immunology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; SUSCEPTIBILITY ; COHORT ; BRCA1
英文摘要:

Fibroblast growth factor receptor 2 (FGFR2), a recently described risk factor for breast cancer, plays important roles in cell growth, invasiveness, motility, and angiogenesis. In attempt to investigate whether FGFR2 polymorphisms are associated with a risk of breast cancer in Chinese women of the Han nationality, we genotyped single-nucleotide polymorphisms (SNPs) of seven FGFR2 sites (rs2981582, rs17102287, rs17542768, rs10510097, rs11200012, rs3750817, rs2981578) in 816 women including 388 breast cancer patients and 428 healthy controls via the polymerase chain reaction single-strand conformation polymorphism procedure as well as sequence detection. Our results suggest that the A allele and AA genotype of SNP rs2981578 appear to be protective factors associated with breast cancer, while the CT genotype of SNP rs3750817 is a putative risk factor.

语种: 英语
所属项目编号: 30801014 ; 31001051 ; Q20091001
项目资助者: National Natural Science Foundation of China ; Department of Education of Hubei Province
WOS记录号: WOS:000300831200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61948
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Hubei Univ, Sch Life Sci, Wuhan 430062, Peoples R China
2.Hainan Med Coll, Hainan Prov Key Lab Trop Med, Haikou 571101, Peoples R China
3.Peking Univ, Dept Med Oncol, Key Lab Carcinogenesis & Translat Res, Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Henan Univ Sci & Techol, Med Engn Lab, Coll Med Technol & Engn, Luoyang 471003, Peoples R China
5.Wuhan TB Dispensary, Wuhan 430030, Peoples R China

Recommended Citation:
Chen, Fan,Lv, Min,Xue, Yun,et al. Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality[J]. IMMUNOGENETICS,2012,64(1):71-76.
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