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学科主题: 临床医学
题名:
Effects of high-intensity interval versus continuous moderate-intensity aerobic exercise on apoptosis, oxidative stress and metabolism of the infarcted myocardium in a rat model
作者: Lu, Kai1,2; Wang, Li2; Wang, Changying2; Yang, Yuan1,2; Hu, Dayi1; Ding, Rongjing1
关键词: aerobic exercise training ; myocardial infarction ; cardiac function
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2015-08-01
DOI: 10.3892/mmr.2015.3669
卷: 12, 期:2, 页:2374-2382
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: STIMULATED GLUCOSE-UPTAKE ; ACTIVATED PROTEIN-KINASE ; SKELETAL-MUSCLE ; CARDIAC REHABILITATION ; ADIPOSE-TISSUE ; OXYGEN-UPTAKE ; HEART ; CARDIOPROTECTION ; REDUCTION ; DISEASE
英文摘要:

The optimal aerobic exercise training (AET) protocol for patients following myocardial infarction (MI) has remained under debate. The present study therefore aimed to compare the effects of continuous moderate-intensity training (CMT) and high-intensity interval training (HIT) on cardiac functional recovery, and to investigate the potential associated mechanisms in a post-MI rat model. Female Sprague Dawley rats (8-10 weeks old) undergoing MI or sham surgery were subsequently submitted to CMT or HIT, or kept sedentary for eight weeks. Prior to and following AET, echocardiographic parameters and exercise capacity of the rats were measured. Western blotting was used to evaluate the levels of apoptosis and associated signaling pathway protein expression. The concentrations of biomarkers of oxidative stress were also determined by ELISA assay. Messenger (m) RNA levels and activity of the key enzymes for glycolysis and fatty acid oxidation, as well as the rate of adenosine triphosphate (ATP) synthesis, were also measured. Compared with the MI group, exercise capacity and cardiac function were significantly improved following AET, particularly following HIT. Left ventricular ejection fraction and fraction shortening were further improved in the MI-HIT group in comparison to that of the MI-CMT group. The two forms of AET almost equally attenuated apoptosis of the post-infarction myocardium. CMT and HIT also alleviated oxidative stress by decreasing the concentration of malondialdehyde and increasing the concentration of superoxide dismutase and glutathione peroxidase (GPx). In particular, HIT induced a greater increase in the concentration of GPx than that of CMT. AET, and HIT in particular, significantly increased the levels of mRNA and the maximal activity of phosphofructokinase-1 and carnitine palmitoyl transferase-1, as well as the maximal ratio of ATP synthesis. In addition, compared with the MI group, the expression of signaling proteins PI3K, Akt, p38mapk and AMPK was significantly altered in the MI-CMT and MI-HIT groups. HIT was superior to CMT in its ability to improve cardiac function and exercise capability in a post-MI rat model. HIT was also superior to CMT with regard to attenuating oxidative stress and improving glucolipid metabolism of the post-MI myocardium.

语种: 英语
所属项目编号: 2013BAI06B02
项目资助者: Ministry of Science and Technology of China
WOS记录号: WOS:000358678600107
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61949
Appears in Collections:北京大学第二临床医学院_心外科_期刊论文

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作者单位: 1.Peking Univ Peoples Hosp, Ctr Heart, Beijing 100044, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China

Recommended Citation:
Lu, Kai,Wang, Li,Wang, Changying,et al. Effects of high-intensity interval versus continuous moderate-intensity aerobic exercise on apoptosis, oxidative stress and metabolism of the infarcted myocardium in a rat model[J]. MOLECULAR MEDICINE REPORTS,2015,12(2):2374-2382.
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