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学科主题临床医学
The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus
Wang, GY; Qian, RG; Li, QF; Niu, TH; Chen, GZ; Xu, XP
关键词type 2 diabetes mellitus PPP1R3 gene polymorphism
刊名CHINESE MEDICAL JOURNAL
2001-12-01
114期:12页:1258-1262
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]PROTEIN PHOSPHATASE-1 ; REGULATORY SUBUNIT ; INSULIN-RESISTANCE ; GLYCOGEN-SYNTHASE ; SKELETAL-MUSCLE ; ACTIVATION ; MECHANISM ; NIDDM
英文摘要

Objective To detect the relationship between the polymorphism of the glycogen-targeting regulatory subunit of the skeletal muscle glycogen-associated protein phosphatase 1 ( PPP1R3) gene and type 2 diabetes by case-control study.

Methods We genotyped the PPP1R3 gene Asp905Tyr polymorphism and a common 3′-untranslated region AT (AU)-rich element (ARE) polymorphism in 101 type 2 diabetic patients and 101 controls by oligonucleotide ligation assay (OLA) and polyacrylamide gel elecrophoresis, respectively.

Results Subjects with Tyr/Tyr genotypes whose body mass index (BMI) < 25 were used as the reference group. Those whose BMI25 with Asp905 had a 3.66-fold increase (95% CI: 1.48 - 9.06, P = 0.005) in type 2 diabetes risk. No association was found between 3′ UTR ARE polymorphism and type 2 diabetes mellitus (OR = 1.15; 95% CI: 0.62 - 2.14, P = 0.65).

Conclusion A joint effect between the Asp905 and BMI increases the risk of type 2 diabetes, and Asp905Tyr and ARE polymorphism of PPP1R3 gene are not the major diabetogenic gene variants in Chinese population.

语种英语
WOS记录号WOS:000173061100006
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61953
专题北京大学第三临床医学院_内分泌科
作者单位1.Beijing Univ, Affiliated Hosp 3, Dept Endocrinol, Beijing 100083, Peoples R China
2.Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
3.Beijing Univ, Affiliated Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Wang, GY,Qian, RG,Li, QF,et al. The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus[J]. CHINESE MEDICAL JOURNAL,2001,114(12):1258-1262.
APA Wang, GY,Qian, RG,Li, QF,Niu, TH,Chen, GZ,&Xu, XP.(2001).The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus.CHINESE MEDICAL JOURNAL,114(12),1258-1262.
MLA Wang, GY,et al."The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus".CHINESE MEDICAL JOURNAL 114.12(2001):1258-1262.
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