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学科主题: 临床医学
题名:
The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus
作者: Wang, GY; Qian, RG; Li, QF; Niu, TH; Chen, GZ; Xu, XP
关键词: type 2 diabetes mellitus ; PPP1R3 gene ; polymorphism
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-12-01
卷: 114, 期:12, 页:1258-1262
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PROTEIN PHOSPHATASE-1 ; REGULATORY SUBUNIT ; INSULIN-RESISTANCE ; GLYCOGEN-SYNTHASE ; SKELETAL-MUSCLE ; ACTIVATION ; MECHANISM ; NIDDM
英文摘要:

Objective To detect the relationship between the polymorphism of the glycogen-targeting regulatory subunit of the skeletal muscle glycogen-associated protein phosphatase 1 ( PPP1R3) gene and type 2 diabetes by case-control study.

Methods We genotyped the PPP1R3 gene Asp905Tyr polymorphism and a common 3′-untranslated region AT (AU)-rich element (ARE) polymorphism in 101 type 2 diabetic patients and 101 controls by oligonucleotide ligation assay (OLA) and polyacrylamide gel elecrophoresis, respectively.

Results Subjects with Tyr/Tyr genotypes whose body mass index (BMI) < 25 were used as the reference group. Those whose BMI25 with Asp905 had a 3.66-fold increase (95% CI: 1.48 - 9.06, P = 0.005) in type 2 diabetes risk. No association was found between 3′ UTR ARE polymorphism and type 2 diabetes mellitus (OR = 1.15; 95% CI: 0.62 - 2.14, P = 0.65).

Conclusion A joint effect between the Asp905 and BMI increases the risk of type 2 diabetes, and Asp905Tyr and ARE polymorphism of PPP1R3 gene are not the major diabetogenic gene variants in Chinese population.

语种: 英语
WOS记录号: WOS:000173061100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61953
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: 1.Beijing Univ, Affiliated Hosp 3, Dept Endocrinol, Beijing 100083, Peoples R China
2.Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
3.Beijing Univ, Affiliated Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Wang, GY,Qian, RG,Li, QF,et al. The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus[J]. CHINESE MEDICAL JOURNAL,2001,114(12):1258-1262.
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