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学科主题基础医学
EGFR Mutations are More Frequent in Well-Differentiated than in Poor-Differentiated Lung Adenocarcinomas
Liu, Yan1,2; Xu, Mei Lin2; Zhong, Hao Hao1; Heng, Wan Jie1; Wu, Bing Quan1
关键词Chemotherapy Epidermal growth factor receptor Lung adenocarcinoma Polymerase chain reaction Sequence analysis
刊名PATHOLOGY & ONCOLOGY RESEARCH
2008-12-01
DOI10.1007/s12253-008-9113-1
14期:4页:373-379
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; TYROSINE KINASE DOMAIN ; PROLONGED SURVIVAL ; CANCER PATIENTS ; GEFITINIB ; GENE ; THERAPY
英文摘要

Somatic mutations in epidermal growth factor receptor (EGFR) tyrosine kinase domain, particularly deletions in exon 19 and point mutation in exon 21, are associated with clinical outcome in patients with lung adenocarcinoma, suggesting that EGFR mutation would have an important role in clinical decision making. DNA was extracted from the excised specimens of 60 lung adenocarcinoma patients with phenol-chloroform and ethanol precipitation. Exon 19 and 21 were amplified by PCR, and direct sequenced from both sense and antisense directions. EGFR somatic mutations were present in 13 of 60 patients (21.67%), including seven cases of in-frame deletion in exon 19 around codon 746 and six cases of amino acid substitution in exon 21. Exon 21 mutation is more frequent in adenocarcinomas with bronchi-alveolar component than exon 19 deletions. Mutations were more prevalent in well-differentiated adenocarcinomas (9/27, 33.33%) than in moderate to poor-differentiated adenocarcinomas (4/33, 12.12%) (P < 0.05). Adenocarcinomas with bronchi-alveolar components had higher mutation frequency (8/22,36. 36%) than those without bronchi-alveolar components (5/38, 13.16%) (P < 0.05). In this study, female patients had more mutation rate than male patients. This trend was also observed in the patients with pathologic stage I-II compared with stage III-IV, but neither of them was statistically significant. Patients with cisplatin-based adjuvant chemotherapy had no significantly prolonged survival compared with single radical resection. But patients with EGFR mutation had relative longer survival. In conclusion, our study suggest that EGFR mutations may be a valuable prognostic factor for disease free survival of surgically treated lung adenocarcinoma patients independently from adjuvant chemotherapy.

语种英语
WOS记录号WOS:000263154900004
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61962
专题基础医学院_病理学系
作者单位1.Tianjin Chest Hosp, Dept Pathol, Tianjin 300051, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Lab Mol Pathol, Dept Pathol, Beijing 100191, Peoples R China
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GB/T 7714
Liu, Yan,Xu, Mei Lin,Zhong, Hao Hao,et al. EGFR Mutations are More Frequent in Well-Differentiated than in Poor-Differentiated Lung Adenocarcinomas[J]. PATHOLOGY & ONCOLOGY RESEARCH,2008,14(4):373-379.
APA Liu, Yan,Xu, Mei Lin,Zhong, Hao Hao,Heng, Wan Jie,&Wu, Bing Quan.(2008).EGFR Mutations are More Frequent in Well-Differentiated than in Poor-Differentiated Lung Adenocarcinomas.PATHOLOGY & ONCOLOGY RESEARCH,14(4),373-379.
MLA Liu, Yan,et al."EGFR Mutations are More Frequent in Well-Differentiated than in Poor-Differentiated Lung Adenocarcinomas".PATHOLOGY & ONCOLOGY RESEARCH 14.4(2008):373-379.
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