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学科主题: 临床医学
题名:
Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke
作者: Qi, Ai-qin1; Li, Yan1; Liu, Qiang1; Si, Jun-Zeng1; Tang, Xiao-Mei2; Zhang, Zhi-Qiang3; Qi, Qin-De1; Chen, Wei-Bi4
关键词: Acute ischemic stroke ; Thioredoxin ; Diagnostic ; Prognostic ; Chinese
刊名: FREE RADICAL BIOLOGY AND MEDICINE
发表日期: 2015-03-01
DOI: 10.1016/j.freeradbiomed.2014.12.021
卷: 80, 页:129-135
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: OXIDATIVE STRESS ; CEREBRAL INFARCTION ; INFLAMMATION ; SENSITIVITY ; DISEASE ; CLASSIFICATION ; PATHOGENESIS ; EXPRESSION ; MOLECULES ; BIOMARKER
英文摘要:

Serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity, was recognized as an oxidative-stress marker. The purpose of this study was to investigate the potential diagnostic and prognostic role of TRX in Chinese patients with acute ischemic stroke (AIS). From January 1, 2012, to December 31, 2013, all patients with first-ever acute ischemic stroke were recruited to participate in the study. Serum levels of TRX were assayed with solid-phase sandwich ELISA, and severity of stroke was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score on admission. Short-term functional outcome was measured by a modified Rankin scale (mRS) 3 months after admission. Multivariate analyses were performed using logistic regression models. We found the serum TRX reflected the disease severity of AIS. There was a significant positive association between serum TRX levels and NIHSS scores (r = 0.476, P < 0.0001). Based on the ROC curve, the optimal cutoff value of serum TRX levels as an indicator for auxiliary diagnosis of AIS was projected to be 11.0 ng/ml, which yielded a sensitivity of 80.3% and a specificity of 73.7%, with the area under the curve at 0.807 (95% Cl, 0.766-0.847). Elevated TRX ( >= 20.0 ng/ml) was an independent prognostic marker of short-term functional outcome [odds ratio (OR) 9.482 (95% Cl, 3.11-8.15) P < 0.0001; adjusted for NIHSS, other predictors and vascular risk factors] in patients with AIS. TRX improved the area under the receiver operating characteristic curve of the NHISS score for functional outcome from 0.722 (95% Cl, 0.66-20.782) to 0.905 (95% CI, 0.828-0.962; P < 0.0001). Our study demonstrated that elevated serum TRX level at admission was a novel diagnostic and prognostic marker in patients with acute ischemic stroke. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000351485000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61963
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: 1.Laiwu Peoples Hosp, Dept Cardiol, Laiwu 271100, Shandong, Peoples R China
2.Peoples Hosp Laiwu City, Dept Neurol, Laiwu 271100, Shandong, Peoples R China
3.Peking Univ, Hosp 3, Dept Neurol, Beijing Haidian Hosp,Haidian Sect, Beijing, Peoples R China
4.Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China

Recommended Citation:
Qi, Ai-qin,Li, Yan,Liu, Qiang,et al. Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke[J]. FREE RADICAL BIOLOGY AND MEDICINE,2015,80:129-135.
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