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Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke
Qi, Ai-qin1; Li, Yan1; Liu, Qiang1; Si, Jun-Zeng1; Tang, Xiao-Mei2; Zhang, Zhi-Qiang3; Qi, Qin-De1; Chen, Wei-Bi4
关键词Acute ischemic stroke Thioredoxin Diagnostic Prognostic Chinese
刊名FREE RADICAL BIOLOGY AND MEDICINE
2015-03-01
DOI10.1016/j.freeradbiomed.2014.12.021
80页:129-135
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]OXIDATIVE STRESS ; CEREBRAL INFARCTION ; INFLAMMATION ; SENSITIVITY ; DISEASE ; CLASSIFICATION ; PATHOGENESIS ; EXPRESSION ; MOLECULES ; BIOMARKER
英文摘要

Serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity, was recognized as an oxidative-stress marker. The purpose of this study was to investigate the potential diagnostic and prognostic role of TRX in Chinese patients with acute ischemic stroke (AIS). From January 1, 2012, to December 31, 2013, all patients with first-ever acute ischemic stroke were recruited to participate in the study. Serum levels of TRX were assayed with solid-phase sandwich ELISA, and severity of stroke was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score on admission. Short-term functional outcome was measured by a modified Rankin scale (mRS) 3 months after admission. Multivariate analyses were performed using logistic regression models. We found the serum TRX reflected the disease severity of AIS. There was a significant positive association between serum TRX levels and NIHSS scores (r = 0.476, P < 0.0001). Based on the ROC curve, the optimal cutoff value of serum TRX levels as an indicator for auxiliary diagnosis of AIS was projected to be 11.0 ng/ml, which yielded a sensitivity of 80.3% and a specificity of 73.7%, with the area under the curve at 0.807 (95% Cl, 0.766-0.847). Elevated TRX ( >= 20.0 ng/ml) was an independent prognostic marker of short-term functional outcome [odds ratio (OR) 9.482 (95% Cl, 3.11-8.15) P < 0.0001; adjusted for NIHSS, other predictors and vascular risk factors] in patients with AIS. TRX improved the area under the receiver operating characteristic curve of the NHISS score for functional outcome from 0.722 (95% Cl, 0.66-20.782) to 0.905 (95% CI, 0.828-0.962; P < 0.0001). Our study demonstrated that elevated serum TRX level at admission was a novel diagnostic and prognostic marker in patients with acute ischemic stroke. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000351485000014
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61963
专题北京大学第三临床医学院_神经内科
作者单位1.Laiwu Peoples Hosp, Dept Cardiol, Laiwu 271100, Shandong, Peoples R China
2.Peoples Hosp Laiwu City, Dept Neurol, Laiwu 271100, Shandong, Peoples R China
3.Peking Univ, Hosp 3, Dept Neurol, Beijing Haidian Hosp,Haidian Sect, Beijing, Peoples R China
4.Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China
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Qi, Ai-qin,Li, Yan,Liu, Qiang,et al. Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke[J]. FREE RADICAL BIOLOGY AND MEDICINE,2015,80:129-135.
APA Qi, Ai-qin.,Li, Yan.,Liu, Qiang.,Si, Jun-Zeng.,Tang, Xiao-Mei.,...&Chen, Wei-Bi.(2015).Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke.FREE RADICAL BIOLOGY AND MEDICINE,80,129-135.
MLA Qi, Ai-qin,et al."Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke".FREE RADICAL BIOLOGY AND MEDICINE 80(2015):129-135.
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