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Variability of warfarin dose response associated with CYP2C9 and VKORC1 gene polymorphisms in Chinese patients
Ye, Changqing1; Jin, Haiqiang1; Zhang, Rui2; Sun, Yongan1; Wang, Zhaoxia1; Sun, Weiping1; Sun, Wei1; Peng, Qing1; Liu, Ran1; Huang, Yining1
关键词Warfarin single nucleotide polymorphism international normalized ratio (INR) cytochrome P450 family 2 subfamily C polypeptide 9 (CYP2C9) vitamin K epoxide reductase complex subunit 1 (VKORC1)
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2014-02-01
DOI10.1177/0300060513499094
42期:1页:67-76
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]PHARMACOGENOMICS ; SENSITIVITY ; POPULATION ; ANTICOAGULATION ; VARIANTS
英文摘要

Objective To investigate the prevalence and implication of cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9) variants and vitamin K epoxide reductase complex, subunit 1 (VKORC1)-1639G>A polymorphisms in Chinese patients receiving warfarin therapy.

Methods Chinese Han patients requiring oral warfarin therapy were consecutively enrolled. Correlations between CYP2C9*1, *2, *3, *4, *5 variants and VKORC1-1639G>A polymorphisms, fourth-day international normalized ratios (INRs) and warfarin maintenance dose were investigated.

Results Out of 101 patients, there were no significant differences in fourth-day INR or warfarin daily maintenance doses between patients with CYP2C9*1*1 and CYP2C9*1*3 genotypes. Patients with the VKORC1-1639 AA genotype had a higher fourth-day INR (1.870.14) than those with the VKORC1-1639 AG genotype (1.32 +/- 0.15). Warfarin maintenance dose for patients with the VKORC1-1639 AA genotype (2.40 +/- 0.70mg/day) was significantly lower than for patients with the VKORC1-1639 AG genotype (4.83 +/- 0.70mg/day).

Conclusions Unlike Caucasian populations, VKORC1-1639G>A polymorphisms in the Chinese population may be the dominant genetic factors associated with warfarin response variability.

语种英语
WOS记录号WOS:000329687700007
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61964
专题北京大学第一临床医学院_神经内科
作者单位1.Peking Univ, Dept Neurol, Hosp 1, Beijing 100034, Peoples R China
2.Capital Univ Med Sci, Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Ye, Changqing,Jin, Haiqiang,Zhang, Rui,et al. Variability of warfarin dose response associated with CYP2C9 and VKORC1 gene polymorphisms in Chinese patients[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2014,42(1):67-76.
APA Ye, Changqing.,Jin, Haiqiang.,Zhang, Rui.,Sun, Yongan.,Wang, Zhaoxia.,...&Huang, Yining.(2014).Variability of warfarin dose response associated with CYP2C9 and VKORC1 gene polymorphisms in Chinese patients.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,42(1),67-76.
MLA Ye, Changqing,et al."Variability of warfarin dose response associated with CYP2C9 and VKORC1 gene polymorphisms in Chinese patients".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 42.1(2014):67-76.
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