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学科主题: 临床医学
题名:
Augmentation of Pedicle Screw Fixation Strength Using an Injectable Calcium Sulfate Cement An In Vivo Study
作者: Yi, Xiaodong; Wang, Yu; Lu, Hailin; Li, Chunde; Zhu, Tianyue
关键词: calcium sulfate ; injectable cement ; pedicle screw fixation ; augmentation of pedicle screw fixation ; axial pull-out strength
刊名: SPINE
发表日期: 2008-11-01
卷: 33, 期:23, 页:2503-2509
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Orthopedics
研究领域[WOS]: Neurosciences & Neurology ; Orthopedics
关键词[WOS]: EARLY BONY CONSOLIDATION ; DISTRACTION OSTEOGENESIS ; REVISION ; CHITOSAN ; MODEL
英文摘要:

Study Design. An in vivo landrace model of cement augmentation of pedicle screw was established, and axial pull-out tests and histological analysis were performed.

Objective. To investigate the long-term in vivo biomechanical performance of pedicle screws augmented with calcium sulfate cement.

Summary of Background Data. Little information is available on the long-term biomechanical performance of pedicle screws augmented with calcium sulfate cement in vivo.

Methods. Ten pedicle screws were implanted into the lumbar vertebrae of 15 adult females landraces weighing 105 to 115 kg. The pedicle screws were augmented with Polymethyl methacrylate (PMMA), augmented with the calcium sulfate cement, or not augmented. The landraces were randomized into 3 study periods of day 1, 6 weeks, and 12 weeks. At the end of the assigned study periods, the animals were killed and axial pull-out tests and histological analyses were conducted on the isolated specimen vertebrae.

Results. No significant difference was found among the 1-day, 6-week, and 12-week control group (P > 0.18), no significant difference was found among the 1-day, 6-week and 12-week PMMA group (P > 0.59), and no significant difference was found among the 1-day, 6-week and 12-week calcium sulfate group (P > 0.27). The maximum POS of the PMMA groups was significantly greater than that of the calcium sulfate groups (P < 0.002), the maximum POS of the calcium sulfate groups was significantly greater than that of the control groups (P < 0.004).

Histologically progressive absorption of the calcium sulfate was evident. The bone walls around the screws in the 12-week calcium sulfate group were statistically significantly thicker than that of the 12-week control group and that of the 12-week PMMA group.

Conclusion. Results of this study demonstrate that the injectable calcium sulfate cement can significantly improve the immediate POS of pedicle screw fixation, and this effect can be maintained even if the calcium sulfate cement has been absorbed completely, which may result from that the calcium sulfate cement resorption paralleled bone ingrowth.

语种: 英语
项目资助者: Wright Medical Technology, Inc, Arlingteon, Tenn.
WOS记录号: WOS:000260673300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61970
Appears in Collections:北京大学第一临床医学院_骨科_期刊论文

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作者单位: Peking Univ, Dept Orthopaed Surg, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Yi, Xiaodong,Wang, Yu,Lu, Hailin,et al. Augmentation of Pedicle Screw Fixation Strength Using an Injectable Calcium Sulfate Cement An In Vivo Study[J]. SPINE,2008,33(23):2503-2509.
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