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学科主题: 精神卫生
题名:
Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder: a three-month observational study
作者: Li Hui-chun1; Zhang Ming-yuan2; Wang Gang3; Zhang Hong-geng4; Zhang Hong-yan5; Liu Ying6; Li Ming7; Zhang Cong-pei8; Tang Ji-sheng9; Wu Wen-yuan10; Singh, Pritibha11; Granger, Renee Elizabeth11; Raskin, Joel12; Ang Qiu-qing13
关键词: depressive disorder ; major ; pain ; quality of life ; epidemiology ; public health ; China
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-08-05
DOI: 10.3760/cma.j.issn.0366-6999.2010.15.020
卷: 123, 期:15, 页:2063-2069
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: QUALITY-OF-LIFE ; SOMATIC SYMPTOMS ; PRIMARY-CARE ; HEALTH-CARE ; SEVERITY ; AMERICA ; IMPACT ; ASIA
英文摘要:

Background Painful physical symptoms (PPS) may present as a component of major depressive disorder (MDD). Their effect in Chinese patients has not been investigated. This analysis reports the changes in disease severity, treatment patterns, quality of life and outcomes in a Chinese cohort according to the presence (PPS+) or absence (PPS-) of painful physical symptoms.

Methods A subgroup of Chinese patients from a large observational 3-month study of patients from Asian countries and regions of China were classified using the modified Somatic Symptom Inventory (SSI) as PPS+ (mean score >= 2) or PPS- (mean score <2). Depression severity was assessed with the Clinical Global Impression of Severity (CGI-S) scale and 17-item Hamilton depression rating scale (HAMD(17)). Pain severity was measured using a visual analogue scale (VAS), while the EuroQoL (EQ-5D) assessed patient well-being. Antidepressants were compared with regard to their efficacy.

Results Of the 299 Chinese patients enrolled in the study, 105 were classified as PPS+ (73/105, 70% women). At baseline, PPS+ patients reported greater pain severity (VAS, mean (SD): 49.56 (26.49) vs. 16.60 (20.99) for PPS-, P <0.01), were more depressed (HAMD(17), mean (SD): 25.32 (5.47) vs. 23.33 (5.24) for PPS-, P=0.002) and had poorer quality of life (EQ-5D Health State, mean (SD): 38.48 (22.38) vs. 49.57 (18.54) for PPS-, P <0.001). PPS+ patients showed less overall improvement in depressive symptom severity (HAMD(17), change from baseline (95% CI): -17.38 (-18.65, -16.12) vs. -19.20 (-20.05, -18.35) for PPS-, P=0.032; CGI-S, change from baseline (95% CI): -2.85 (-3.11, -2.58) vs. -3.20 (-3.38, -3.02) for PPS-, P=0.044).

Conclusions PPS were less frequent than expected compared with previous studies of Asian populations. PPS+ were associated with greater MDD severity and less improvement than PPS when antidepressants were given. Chin Med J 2010;123(15):2063-2069

语种: 英语
所属项目编号: F1J-AA-B015
项目资助者: Eli Lilly and Company, Indianapolis, USA
WOS记录号: WOS:000281025400021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61972
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Psychiat, Hangzhou 310009, Zhejiang, Peoples R China
2.Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China
3.An Ding Hosp, Beijing 100088, Peoples R China
4.Hunan Prov Hosp Brain Dis, Mental Hlth Ctr, Changsha 410007, Hunan, Peoples R China
5.Beijing Univ, Hosp 6, Beijing 100083, Peoples R China
6.China Med Univ, Hosp 1, Shenyang 110001, Liaoning, Peoples R China
7.Suzhou Guang Ji Hosp, Suzhou 215008, Jiangsu, Peoples R China
8.Harbin First Spec Hosp, Harbin 150056, Heilongjiang, Peoples R China
9.Shandong Mental Hlth Ctr, Jinan 250014, Shandong, Peoples R China
10.Tongji Univ, Tongji Hosp, Shanghai 430030, Peoples R China
11.Eli Lilly Australia Pty Ltd, Intercontinental Informat Sci, Macquarie Pk 2113, Australia
12.Eli Lilly Canada, Lilly Res Labs, Toronto, ON M1N 2E8, Canada
13.Eli Lilly Asia Inc, Shanghai 200021, Peoples R China

Recommended Citation:
Li Hui-chun,Zhang Ming-yuan,Wang Gang,et al. Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder: a three-month observational study[J]. CHINESE MEDICAL JOURNAL,2010,123(15):2063-2069.
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