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Uptake of cyclosporine A loaded colloidal drug carriers by mouse peritoneal macrophages in vitro
Wang, J; Zhang, Q
关键词cyclosporins microspheres capsules emulsions peritoneal macrophages
刊名ACTA PHARMACOLOGICA SINICA
2001
22期:1页:57-61
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]MONONUCLEAR PHAGOCYTE SYSTEM ; IN-VITRO ; NANOPARTICLES ; DELIVERY ; PARTICLES ; VIVO
英文摘要

AIM: To investigate the uptake of cyclosporine A loaded colloidal drug carriers by mouse peritoneal macrophage (MPM) in vitro. METHODS: The [H-3]cyclosporine A loaded colloidal particles: polylactic acid nanospheres, polylactic acid nanocapsules, and microemulsions were prepared. The [H-3]cyclosporine A loaded colloidal particles were incubated with MPM for 30 min at 31 degreesC, then the cells were separated from the colloidal particles and the radioactivity was measured by a liquid scintillation counter. RESULTS: In comparison to the cyclosporine A solution, the binding to, polylactic acid nanospheres produced a 20-fold increase in the uptake of cyclosporine A by MPM in 30 min incubation, whereas some obvious decrease in the uptake of cyclosporine A by MPM was observed in the binding of cyclosporine A with polylactic acid nanocapsules or microemulsions. The surfactant coating and plasma protein adsorption were found to have marked effects on the uptake of cyclosporine A loaded nanopheres by MPM. CONCLUSION: Our present study indicated that colloidal drug carriers might affect the targeting of cyclosporine A to mononuclear phagocyte system.

语种英语
WOS记录号WOS:000166435900012
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61973
专题北京大学药学院_药剂学系
作者单位Beijing Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, J,Zhang, Q. Uptake of cyclosporine A loaded colloidal drug carriers by mouse peritoneal macrophages in vitro[J]. ACTA PHARMACOLOGICA SINICA,2001,22(1):57-61.
APA Wang, J,&Zhang, Q.(2001).Uptake of cyclosporine A loaded colloidal drug carriers by mouse peritoneal macrophages in vitro.ACTA PHARMACOLOGICA SINICA,22(1),57-61.
MLA Wang, J,et al."Uptake of cyclosporine A loaded colloidal drug carriers by mouse peritoneal macrophages in vitro".ACTA PHARMACOLOGICA SINICA 22.1(2001):57-61.
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