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学科主题: 药学
题名:
Anti-neuroinflammatory constituents from Asparagus cochinchinensis
作者: Jian, Rui1; Zeng, Ke-Wu1; Li, Jun2; Li, Ning1; Jiang, Yong1; Tu, Pengfei1
关键词: Asparagus cochinchinensis ; Steroidal saponin ; Pregnane glycoside ; Furostanol glycoside ; Aspacochinoside
刊名: FITOTERAPIA
发表日期: 2013
DOI: 10.1016/j.fitote.2012.10.011
卷: 84, 页:80-84
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: STEROIDAL SAPONINS
英文摘要:

Three new pregnane glycosides, aspacochinosides N (1), O (2), and P (3) were isolated from the roots of Asparagus cochinchinensis, together with four known furostanol glycosides. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1-7 were evaluated for their anti-neuroinflammatory activity in LPS-induced BV-2 microglial cells. Compounds 2, 3, and 4 showed significant inhibition on NO production in LPS-induced BV-2 microglial cells with IC50 values of 13.51, 4.72, and 63.57 mu M, respectively. (c) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012ZX09301002-002-002 ; 2012ZX09304-005
项目资助者: National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号: WOS:000316531400013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61975
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

Recommended Citation:
Jian, Rui,Zeng, Ke-Wu,Li, Jun,et al. Anti-neuroinflammatory constituents from Asparagus cochinchinensis[J]. FITOTERAPIA,2013,84:80-84.
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