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Anti-neuroinflammatory constituents from Asparagus cochinchinensis
Jian, Rui1; Zeng, Ke-Wu1; Li, Jun2; Li, Ning1; Jiang, Yong1; Tu, Pengfei1
关键词Asparagus cochinchinensis Steroidal saponin Pregnane glycoside Furostanol glycoside Aspacochinoside
刊名FITOTERAPIA
2013
DOI10.1016/j.fitote.2012.10.011
84页:80-84
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]STEROIDAL SAPONINS
英文摘要

Three new pregnane glycosides, aspacochinosides N (1), O (2), and P (3) were isolated from the roots of Asparagus cochinchinensis, together with four known furostanol glycosides. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1-7 were evaluated for their anti-neuroinflammatory activity in LPS-induced BV-2 microglial cells. Compounds 2, 3, and 4 showed significant inhibition on NO production in LPS-induced BV-2 microglial cells with IC50 values of 13.51, 4.72, and 63.57 mu M, respectively. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000316531400013
项目编号2012ZX09301002-002-002 ; 2012ZX09304-005
资助机构National Key Technology R&amp ; D Program "New Drug Innovation" of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61975
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
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GB/T 7714
Jian, Rui,Zeng, Ke-Wu,Li, Jun,et al. Anti-neuroinflammatory constituents from Asparagus cochinchinensis[J]. FITOTERAPIA,2013,84:80-84.
APA Jian, Rui,Zeng, Ke-Wu,Li, Jun,Li, Ning,Jiang, Yong,&Tu, Pengfei.(2013).Anti-neuroinflammatory constituents from Asparagus cochinchinensis.FITOTERAPIA,84,80-84.
MLA Jian, Rui,et al."Anti-neuroinflammatory constituents from Asparagus cochinchinensis".FITOTERAPIA 84(2013):80-84.
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