IR@PKUHSC  > 北京大学药学院
学科主题药学
Anti-neuroinflammatory constituents from Asparagus cochinchinensis
Jian, Rui1; Zeng, Ke-Wu1; Li, Jun2; Li, Ning1; Jiang, Yong1; Tu, Pengfei1
关键词Asparagus cochinchinensis Steroidal saponin Pregnane glycoside Furostanol glycoside Aspacochinoside
刊名FITOTERAPIA
2013
DOI10.1016/j.fitote.2012.10.011
84页:80-84
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]STEROIDAL SAPONINS
英文摘要

Three new pregnane glycosides, aspacochinosides N (1), O (2), and P (3) were isolated from the roots of Asparagus cochinchinensis, together with four known furostanol glycosides. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1-7 were evaluated for their anti-neuroinflammatory activity in LPS-induced BV-2 microglial cells. Compounds 2, 3, and 4 showed significant inhibition on NO production in LPS-induced BV-2 microglial cells with IC50 values of 13.51, 4.72, and 63.57 mu M, respectively. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2012ZX09301002-002-002 ; 2012ZX09304-005
资助者National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号WOS:000316531400013
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61975
Collection北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Jian, Rui,Zeng, Ke-Wu,Li, Jun,et al. Anti-neuroinflammatory constituents from Asparagus cochinchinensis[J]. FITOTERAPIA,2013,84:80-84.
APA Jian, Rui,Zeng, Ke-Wu,Li, Jun,Li, Ning,Jiang, Yong,&Tu, Pengfei.(2013).Anti-neuroinflammatory constituents from Asparagus cochinchinensis.FITOTERAPIA,84,80-84.
MLA Jian, Rui,et al."Anti-neuroinflammatory constituents from Asparagus cochinchinensis".FITOTERAPIA 84(2013):80-84.
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