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POLAR METABOLITE OF CHOLESTEROL INDUCES RAT COGNITIVE DYSFUNCTIONS
Zhao, S.1; Liao, W.2; Xu, N.3; Xu, H.2; Yu, C.2; Liu, X.3; Li, C.1
关键词24-hydroxycholesterol neurotoxicity neurological disorder Morris water maze
刊名NEUROSCIENCE
2009-12-01
DOI10.1016/j.neuroscience.2009.08.027
164期:2页:398-403
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ALZHEIMERS-DISEASE ; NEURONAL PATHOLOGY ; OXIDATION-PRODUCTS ; ENTORHINAL CORTEX ; AMYLOID LOAD ; CELL-DEATH ; VITAMIN-E ; BRAIN ; 24S-HYDROXYCHOLESTEROL ; 7-KETOCHOLESTEROL
英文摘要

24-hydroxycholesterol, a major polar metabolite of brain cholesterol, has neurotoxic effects. However, little is known about the effects of this polar metabolite on the CNS. In the present study, the effects of 24-hydroxycholesterol on behavior changes were investigated. Rats were divided into three groups: (i) a control group; (ii) a sham group: 0.5 ml PBS was infused into the cerebral ventricle;(iii) a model group: 0.5 ml 24-hydroxycholesterol (10 mu M) was infused into the cerebral ventricle. 24-hydroxycholesterol can obviously impair rats′ acquisition and probe trial in the Morris Water Maze task. Compared with rats in the sham group, rats in the model group had longer escape latency time and traveled more distance, and performed worse in the probe trial task manifested by spending less time in the annulus and training quadrant, which probably was attributed to the neuronal degeneration in hippocampal CA1 area induced by 24-hydroxycholesterol as examined by histological assay and apoptotic assay. Our results revealed that the polar metabolites, such as 24-hydroxycholesterol, exert neurotoxic effects and exacerbate the neuron injury with their abnormal accumulation. These findings suggest that measures taken promptly to eliminate or inhibit the accumulation of polar metabolites should be a potential strategy to prevent neurological dysfunctions and promote the recovery of functional deficits after neurotoxic insult. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000271731700007
资助机构National Health Ministry
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61979
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.China Japan Friendship Hosp, Natl Integrat Med Ctr Cardiovasc Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao, S.,Liao, W.,Xu, N.,et al. POLAR METABOLITE OF CHOLESTEROL INDUCES RAT COGNITIVE DYSFUNCTIONS[J]. NEUROSCIENCE,2009,164(2):398-403.
APA Zhao, S..,Liao, W..,Xu, N..,Xu, H..,Yu, C..,...&Li, C..(2009).POLAR METABOLITE OF CHOLESTEROL INDUCES RAT COGNITIVE DYSFUNCTIONS.NEUROSCIENCE,164(2),398-403.
MLA Zhao, S.,et al."POLAR METABOLITE OF CHOLESTEROL INDUCES RAT COGNITIVE DYSFUNCTIONS".NEUROSCIENCE 164.2(2009):398-403.
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