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学科主题: 药物依赖
题名:
A Meta-Analysis of Acupuncture Combined with Opioid Receptor Agonists for Treatment of Opiate-Withdrawal Symptoms
作者: Liu, Ting-ting1; Shi, Jie1; Epstein, David H.2; Bao, Yan-ping1; Lu, Lin1
关键词: Acupuncture ; Opioid ; Detoxification ; Meta-analysis
刊名: CELLULAR AND MOLECULAR NEUROBIOLOGY
发表日期: 2009-06-01
DOI: 10.1007/s10571-008-9336-4
卷: 29, 期:4, 页:449-454
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; ADDICTION ; MORPHINE ; RATS ; ELECTROACUPUNCTURE ; TOLERANCE ; NUCLEUS ; HEROIN
英文摘要:

This review extends a prior meta-analysis of acupuncture′s utility for treating opioid detoxification, addressing the efficacy of acupuncture when combined with allopathic therapies. Both English and Chinese databases were searched for randomized trials comparing acupuncture combined with opioid agonist treatment versus opioid agonists alone for treating symptoms of opioid withdrawal. The methodological quality of each study was assessed with Jadad′s scale (1-2 = low; 3-5 = high). Meta-analysis was performed with fixed- or random-effect models in RevMan software; the outcome measures assessed were withdrawal-symptoms score, relapse rate, side effects, and medication dosage. Withdrawal-symptom scores were lower in combined treatment trials than in agonist-alone trials on withdrawal days 1, 7, 9, and 10. Combined treatment also produced lower reported rates of side effects and appeared to lower the required dose of opioid agonist. There was no significant difference on relapse rate after 6 months. This meta-analysis suggests that acupuncture combined with opioid agonists can effectively be used to manage the withdrawal symptoms. One limitation of this meta-analysis is the poor quality of the methodology of some included trials. High-quality studies are needed to confirm findings regarding the side effects and medication dosage.

语种: 英语
所属项目编号: 2003CB515400 ; 2006AA02Z4D1 ; 30611120528
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; China-Canada Joint Health Research Program
WOS记录号: WOS:000266921200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61990
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA

Recommended Citation:
Liu, Ting-ting,Shi, Jie,Epstein, David H.,et al. A Meta-Analysis of Acupuncture Combined with Opioid Receptor Agonists for Treatment of Opiate-Withdrawal Symptoms[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2009,29(4):449-454.
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