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学科主题: 临床医学
题名:
The contribution of visceral fat to improved insulin signaling in Ames dwarf mice
作者: Menon, Vinal1; Zhi, Xu1,2; Hossain, Tanvir1; Bartke, Andrzej3; Spong, Adam3; Gesing, Adam1,4; Masternak, Michal M.1,5
关键词: adiponectin ; adipose tissue ; Ames dwarf ; insulin ; obesity
刊名: AGING CELL
发表日期: 2014-06-01
DOI: 10.1111/acel.12201
卷: 13, 期:3, 页:497-506
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Geriatrics & Gerontology
研究领域[WOS]: Cell Biology ; Geriatrics & Gerontology
关键词[WOS]: TUMOR-NECROSIS-FACTOR ; ADIPOSE-TISSUE ; SURGICAL REMOVAL ; RESISTANCE ; LONGEVITY ; ADIPONECTIN ; SENSITIVITY ; EXPRESSION ; OBESITY ; GENE
英文摘要:

Ames dwarf (Prop1df, df/df) mice are characterized by growth hormone (GH), prolactin, and thyrotropin deficiency, remarkable extension of longevity and increased insulin sensitivity with low levels of fasting insulin and glucose. Plasma levels of anti-inflammatory adiponectin are increased in df/df mice, while pro-inflammatory IL-6 is decreased in plasma and epididymal fat. This represents an important shift in the balance between pro- and anti-inflammatory adipokines in adipose tissue, which was not exposed to GH signals during development or adult life. To determine the role of adipose tissue in the control of insulin signaling in these long-living mutants, we examined the effects of surgical removal of visceral (epididymal and perinephric) adipose tissue. Comparison of the results obtained in df/df mice and their normal (N) siblings indicated different effects of visceral fat removal (VFR) on insulin sensitivity and glucose tolerance. The analysis of the expression of genes related to insulin signaling indicated that VFR improved insulin action in skeletal muscle in N mice. Interestingly, this surgical intervention did not improve insulin signaling in df/df mice skeletal muscle but caused suppression of the signal in subcutaneous fat. We conclude that altered profile of adipokines secreted by visceral fat of Ames dwarf mice may act as a key contributor to increased insulin sensitivity and extended longevity of these animals.

语种: 英语
所属项目编号: R01AG032290 ; P01AG031736 ; DEC-2012/04/M/NZ4/00198 ; 507/1-107-05/507-10-050
项目资助者: National Institute on Aging of the National Institutes of Health ; Polish National Science Centre (Medical University of Lodz, Poland)
WOS记录号: WOS:000337523400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61994
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Univ Cent Florida, Burnett Sch Biomed Sci, Coll Med, Orlando, FL 32827 USA
2.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Ctr Reprod Med, Beijing 100191, Peoples R China
3.So Illinois Univ, Dept Internal Med, Sch Med, Springfield, IL 62794 USA
4.Med Univ Lodz, Chair Oncol Endocrinol, Dept Oncol Endocrinol, Lodz, Poland
5.Polish Acad Sci, Inst Human Genet, PL-60479 Poznan, Poland

Recommended Citation:
Menon, Vinal,Zhi, Xu,Hossain, Tanvir,et al. The contribution of visceral fat to improved insulin signaling in Ames dwarf mice[J]. AGING CELL,2014,13(3):497-506.
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