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The contribution of visceral fat to improved insulin signaling in Ames dwarf mice
Menon, Vinal1; Zhi, Xu1,2; Hossain, Tanvir1; Bartke, Andrzej3; Spong, Adam3; Gesing, Adam1,4; Masternak, Michal M.1,5
关键词adiponectin adipose tissue Ames dwarf insulin obesity
刊名AGING CELL
2014-06-01
DOI10.1111/acel.12201
13期:3页:497-506
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Geriatrics & Gerontology
研究领域[WOS]Cell Biology ; Geriatrics & Gerontology
关键词[WOS]TUMOR-NECROSIS-FACTOR ; ADIPOSE-TISSUE ; SURGICAL REMOVAL ; RESISTANCE ; LONGEVITY ; ADIPONECTIN ; SENSITIVITY ; EXPRESSION ; OBESITY ; GENE
英文摘要

Ames dwarf (Prop1df, df/df) mice are characterized by growth hormone (GH), prolactin, and thyrotropin deficiency, remarkable extension of longevity and increased insulin sensitivity with low levels of fasting insulin and glucose. Plasma levels of anti-inflammatory adiponectin are increased in df/df mice, while pro-inflammatory IL-6 is decreased in plasma and epididymal fat. This represents an important shift in the balance between pro- and anti-inflammatory adipokines in adipose tissue, which was not exposed to GH signals during development or adult life. To determine the role of adipose tissue in the control of insulin signaling in these long-living mutants, we examined the effects of surgical removal of visceral (epididymal and perinephric) adipose tissue. Comparison of the results obtained in df/df mice and their normal (N) siblings indicated different effects of visceral fat removal (VFR) on insulin sensitivity and glucose tolerance. The analysis of the expression of genes related to insulin signaling indicated that VFR improved insulin action in skeletal muscle in N mice. Interestingly, this surgical intervention did not improve insulin signaling in df/df mice skeletal muscle but caused suppression of the signal in subcutaneous fat. We conclude that altered profile of adipokines secreted by visceral fat of Ames dwarf mice may act as a key contributor to increased insulin sensitivity and extended longevity of these animals.

语种英语
WOS记录号WOS:000337523400012
项目编号R01AG032290 ; P01AG031736 ; DEC-2012/04/M/NZ4/00198 ; 507/1-107-05/507-10-050
资助机构National Institute on Aging of the National Institutes of Health ; Polish National Science Centre (Medical University of Lodz, Poland)
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61994
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Univ Cent Florida, Burnett Sch Biomed Sci, Coll Med, Orlando, FL 32827 USA
2.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Ctr Reprod Med, Beijing 100191, Peoples R China
3.So Illinois Univ, Dept Internal Med, Sch Med, Springfield, IL 62794 USA
4.Med Univ Lodz, Chair Oncol Endocrinol, Dept Oncol Endocrinol, Lodz, Poland
5.Polish Acad Sci, Inst Human Genet, PL-60479 Poznan, Poland
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GB/T 7714
Menon, Vinal,Zhi, Xu,Hossain, Tanvir,et al. The contribution of visceral fat to improved insulin signaling in Ames dwarf mice[J]. AGING CELL,2014,13(3):497-506.
APA Menon, Vinal.,Zhi, Xu.,Hossain, Tanvir.,Bartke, Andrzej.,Spong, Adam.,...&Masternak, Michal M..(2014).The contribution of visceral fat to improved insulin signaling in Ames dwarf mice.AGING CELL,13(3),497-506.
MLA Menon, Vinal,et al."The contribution of visceral fat to improved insulin signaling in Ames dwarf mice".AGING CELL 13.3(2014):497-506.
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